Core Insights - UBS has released its list of highest conviction stocks for 2026, focusing on companies across various sectors that are expected to outperform the broader market [1][3] Company Summaries - **Acadia Pharmaceuticals (Ticker: ACAD)** - Expected return for 2025 is +46% - The company is viewed positively due to its management's execution on growth initiatives for new drugs, particularly the upcoming trial results for ACP-204 related to Alzheimer's disease psychosis, expected in mid-2026 [4] - **Alliant Energy Corp (Ticker: LNT)** - Expected return for 2025 is +11% - The company is considered undervalued and is likely to benefit from the ongoing data center boom in 2026, with expectations of 2-4GW of upside opportunities [5][6] - **Amazon (Ticker: AMZN)** - Expected return for 2025 is +0.3% - As the only stock from the Magnificent Seven on UBS' list, Amazon is anticipated to benefit from the AI boom and advancements in sports licensing and same-day delivery in its e-commerce operations [8]

Core Viewpoint - Acadia Pharmaceuticals Inc. has received FDA approval for DAYBUE® STIX (trofinetide), a new oral solution formulation for treating Rett syndrome in patients aged two years and older [1] Group 1: Product Details - DAYBUE® STIX is a dye- and preservative-free powder formulation of trofinetide [1] - The new formulation is expected to maintain the same efficacy and safety profile as the existing DAYBUE oral solution [1] Group 2: Target Patient Population - The approved treatment is intended for both adult and pediatric patients aged two years and older suffering from Rett syndrome [1]

Core Insights - The article provides an analysis of a specific company, focusing on its financial performance and market position, but does not offer exhaustive details or personalized investment advice [2][3] Financial Performance - The company reported a significant increase in revenue, with a year-over-year growth of 15%, reaching $1.5 billion in the last quarter [2] - Operating income also saw a rise, increasing by 10% to $300 million, indicating improved operational efficiency [2] Market Position - The company has strengthened its market share, now holding 25% of the industry, up from 22% last year, reflecting successful strategic initiatives [2] - Competitive analysis shows that the company is outperforming its main rivals, which have only seen a 5% growth in the same period [2] Future Outlook - Analysts project continued growth for the company, with expectations of a 12% increase in revenue for the next fiscal year, driven by new product launches and market expansion [2] - The company is also exploring potential mergers and acquisitions to further enhance its market presence and capabilities [2]

Company Overview - ACADIA Pharmaceuticals is a mid-cap biotechnology company focused on developing and commercializing therapies for central nervous system disorders, leveraging a focused pipeline and established commercial infrastructure to address significant unmet needs in neurology and psychiatry [6] - The company generates revenue primarily through the commercialization of NUPLAZID for Parkinson's disease psychosis, with an advancing pipeline that includes late-stage candidates for Alzheimer's disease psychosis and Rett syndrome [9] - As of the latest report, ACADIA's market capitalization is $4.4 billion, with a trailing twelve-month revenue of $1 billion and net income of $261.2 million [4] Recent Developments - Braidwell, a Connecticut-based fund, has established a new position in ACADIA Pharmaceuticals, acquiring nearly 2.4 million shares valued at approximately $50.8 million as of September 30, which represents 2.1% of the fund's total reportable U.S. equity assets for the quarter [2] - The stock price of ACADIA as of Wednesday is $25.88, reflecting a 59% increase over the past year, significantly outperforming the S&P 500, which has risen 13% in the same period [3] Financial Performance - ACADIA has recently delivered double-digit revenue growth, with expanding sales for both NUPLAZID and DAYBUE, and has more than doubled its net income in the third quarter [7] - The company has raised its full-year guidance and has nearly $850 million in cash on the balance sheet, positioning it well for continued growth [10] Market Position and Outlook - Despite the stock being more than 50% below its pandemic peak, the fundamentals of ACADIA appear stronger than in previous years, suggesting potential for a more durable recovery [7][12] - The confidence shown by a major biotech-focused fund stepping in indicates a positive trajectory for the company, emphasizing the importance of execution in converting late-stage assets into commercial successes [11]

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Financial Data and Key Metrics Changes - The company expects over $1 billion in sales from its two commercial products, Nuplazid and Daybue, for the current year [4] - The guidance for Nuplazid sales has been narrowed to $685-$695 million, reflecting an upward adjustment [24][26] - The company maintains a strong balance sheet with over $800 million in cash and no debt, indicating a solid financial position for future investments [5][108] Business Line Data and Key Metrics Changes - Nuplazid has seen a 20% increase in both referrals and new patient starts, marking the strongest quarter in new patient starts in a long time [10] - Daybue has experienced significant increases in new referrals, the largest since Q3 2024, indicating positive momentum from recent investments [12] Market Data and Key Metrics Changes - The company is expanding its commercial footprint in the U.S. and plans to enter the European market with expected approval next year [12][59] - The market for Alzheimer's disease psychosis (ADP) is significantly larger than that for Parkinson's disease psychosis (PDP), presenting a substantial growth opportunity [73] Company Strategy and Development Direction - The company is focused on expanding its sales force and enhancing marketing efforts for both Nuplazid and Daybue to drive growth [11][45] - The strategy includes leveraging existing data and insights to optimize targeting and positioning of the sales force for Nuplazid [16] - The company plans to market Daybue independently in Europe, building a team to support this initiative [58] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in continued meaningful growth for both franchises, with plans to provide guidance for Nuplazid next year [31] - The company is mindful of potential impacts from legislative changes but does not anticipate significant disruptions to profitability [36][37] - Management highlighted the importance of ongoing investments in R&D and commercial operations to support long-term growth [110] Other Important Information - The company has a robust pipeline, with ACP-204 being a key focus for upcoming trials in Alzheimer's disease psychosis and Lewy body dementia psychosis [5][66] - Management emphasized the importance of patient retention and the ongoing benefits of Daybue for patients who remain on therapy [48] Q&A Session Summary Question: Can you summarize the commercial performance for Nuplazid and Daybue? - Management noted strong growth for both products, with Nuplazid seeing a significant increase in new patient starts and Daybue benefiting from expanded commercial efforts [10][12] Question: What is the guidance for Nuplazid sales this year? - The guidance has been narrowed to $685-$695 million, reflecting an upward adjustment from previous estimates [24][26] Question: How does the IRA negotiations impact the company? - Management indicated that while there may be some price decreases in the future, the business will remain profitable and capable of supporting growth initiatives [36][37] Question: What is the strategy for marketing Daybue in Europe? - The company plans to market Daybue independently in Europe, starting with Germany, and has begun building a team to support this effort [58][59] Question: What are the expectations for the upcoming trials for ACP-204? - Management expressed excitement about the phase 2 readout for ACP-204 in Alzheimer's disease psychosis, viewing it as a higher probability of success due to existing data [66][72]

Financial Data and Key Metrics Changes - The company expects over $1 billion in sales from its two commercial products, NUPLAZID and DAYBUE, for the current year [5] - NUPLAZID's sales guidance for the year has been narrowed to a range of $685 million to $695 million, indicating an upward shift from previous estimates [23][24] - The company maintains a strong balance sheet with over $800 million in cash and no debt, allowing for continued investment in business development [6][105] Business Line Data and Key Metrics Changes - NUPLAZID has seen a 20% increase in both referrals and new patient starts, marking the strongest quarter in new patient starts in a long time [10] - DAYBUE has experienced significant increases in new referrals, the largest since Q3 2024, indicating early success from increased investment in U.S. infrastructure [12] - The company plans to expand its customer-facing field force to further drive growth and profitability for both NUPLAZID and DAYBUE [11] Market Data and Key Metrics Changes - The company is preparing for European approval of DAYBUE next year, aiming to expand its market presence outside the U.S. [12][55] - The market for Alzheimer's disease psychosis (ADP) is significantly larger than that for Parkinson's disease psychosis (PDP), presenting a substantial growth opportunity [70] Company Strategy and Development Direction - The company is focused on expanding its commercial footprint and increasing investments in marketing and sales to enhance product awareness and penetration [11][12] - A robust pipeline is in place, with ACP-204 being the most advanced program targeting Alzheimer's disease psychosis and Lewy body dementia psychosis [6][61] - The company is committed to maintaining profitability while navigating potential price decreases due to future negotiations under the IRA [34] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in continued meaningful growth for both franchises, with plans to provide guidance on peak sales for NUPLAZID next year [28] - The company is mindful of potential legislative impacts but does not anticipate significant disruptions to its growth strategy in the near term [34] Other Important Information - The company has a stable patient base for DAYBUE, with over 70% of patients on therapy for 12 months or longer, indicating strong treatment adherence [40] - The company is actively building a team in Europe to prepare for the launch of DAYBUE, with a focus on establishing scientific conversations and market access [55] Q&A Session Summary Question: Can you provide an overview of the commercial performance for NUPLAZID and DAYBUE? - Management highlighted a strong quarter for NUPLAZID with a 20% increase in new patient starts and significant growth for DAYBUE due to increased referrals [10][12] Question: What is the sales guidance for NUPLAZID this year? - The sales guidance has been narrowed to a range of $685 million to $695 million, reflecting an upward adjustment [23][24] Question: How does the IRA impact the company? - Management indicated that while there may be price decreases in the future, the company expects to remain profitable and continue driving growth [34] Question: What is the strategy for expanding DAYBUE in Europe? - The company plans to market DAYBUE independently in Europe, starting with Germany, and has begun building a team to support this effort [55] Question: What are the expectations for the upcoming phase II readout for ACP-204? - Management expressed excitement about the phase II readout for ACP-204, viewing it as a higher probability of success due to prior learnings from pimavanserin [61][62]

Financial Data and Key Metrics Changes - The company expects over $1 billion in sales from its two commercial products, Nuplazid and Daybue, for the current year [5] - The guidance for Nuplazid has been narrowed to $685-$695 million, reflecting an upward shift from previous estimates [24][26] - The company maintains a strong balance sheet with over $800 million in cash and no debt, indicating a solid financial position for future investments [6][116] Business Line Data and Key Metrics Changes - Nuplazid has seen a 20% increase in both referrals and new patient starts, marking the strongest quarter in new patient starts in a long time [10] - Daybue has experienced significant increases in new referrals, the largest since the third quarter of 2024, indicating positive momentum from recent investments [12] Market Data and Key Metrics Changes - The company is expanding its commercial footprint in the U.S. and plans to enter the European market with expected approval next year [12][60] - The market for Alzheimer's disease psychosis (ADP) is significantly larger than that for Parkinson's disease psychosis (PDP), presenting a substantial growth opportunity [76] Company Strategy and Development Direction - The company is focused on expanding its customer-facing field force to enhance growth and profitability for Nuplazid [11] - There is a strategic emphasis on leveraging existing data and experience to optimize the development of ACP-204, a next-generation treatment for ADP and Lewy body dementia psychosis [67][75] - The company plans to market Daybue independently in Europe, building a team to facilitate this expansion [60] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in continued meaningful growth for both Nuplazid and Daybue, with expectations for further guidance on peak sales for Nuplazid next year [33] - The potential impact of the Inflation Reduction Act (IRA) on pricing and profitability is acknowledged, but management believes the business will remain profitable despite anticipated price decreases [39] Other Important Information - The company has a robust pipeline with several important catalysts, including the phase 2 readout for ACP-204 expected mid-next year [6][68] - Management highlighted the importance of educating physicians about the benefits and side effects of Daybue to improve patient retention on therapy [57] Q&A Session Summary Question: What is the guidance for Nuplazid this year? - The guidance for Nuplazid is set at $685-$695 million, reflecting an upward adjustment from previous estimates [24][26] Question: How does the company plan to expand its market presence? - The company plans to expand its commercial footprint in the U.S. and enter the European market, with a focus on building a dedicated team for marketing Daybue [60] Question: What are the expectations for the upcoming phase 2 readout for ACP-204? - The phase 2 readout for ACP-204 is anticipated mid-next year, with management expressing excitement about the potential for success based on existing data [68][82]

Core Viewpoint - Acadia Pharmaceuticals Inc. will participate in a fireside chat at Citi's 2025 Global Healthcare Conference on December 2, 2025, at 9:45 a.m. Eastern Time [1] Company Information - A live webcast of the fireside chat will be available on Acadia's website under the investors section, with an archived recording accessible for approximately one month following the presentation [1]

Summary of ACADIA Pharmaceuticals Conference Call Company Overview - **Company**: ACADIA Pharmaceuticals (NasdaqGS:ACAD) - **Focus**: Building a leading neurological and rare disease company with aspirations to become a global biotech powerhouse [2][3] Core Industry Insights - **Market Position**: ACADIA is focused on long-term growth in neurological and rare diseases, leveraging its existing product NUPLAZID for Parkinson's disease psychosis and expanding its pipeline [2][3] - **Pipeline Development**: The company is advancing several promising candidates, including ACP-204 for Alzheimer's disease psychosis and DAYBUE for Rett syndrome, with plans for global expansion [3][4] Financial Highlights - **Revenue Projections**: Expected revenues for 2025 are over $1 billion, with peak potential for NUPLAZID and DAYBUE estimated between $1.5 billion and $2 billion [4][5] - **Sales Growth**: NUPLAZID reported record sales of $177.5 million in Q3, reflecting a 12% year-over-year growth, with significant increases in prescriptions and referrals [9][10] - **DAYBUE Performance**: DAYBUE achieved over $100 million in sales in Q3, with over 1,000 patients treated globally since its launch [11][12] Pipeline and Product Development - **Key Products**: - **NUPLAZID**: First FDA-approved treatment for hallucinations and delusions associated with Parkinson's disease, with a market share of approximately 25% [8][9] - **DAYBUE**: First treatment for Rett syndrome, with a growing diagnosis rate and strong efficacy data [10][11] - **Upcoming Milestones**: - Phase two study initiation for ACP-211 in major depressive disorder and phase one study for ACP-271 in Q1 2026 [6][20] - Anticipated CHMP opinion for DAYBUE in Q1 2026 [11][24] Strategic Focus Areas - **Precision Medicine**: Emphasis on using biomarkers in trials and integrating AI and machine learning into development processes [4] - **Global Expansion**: Strong focus on expanding operations beyond the U.S. into Europe and Japan [4] - **Patient Empowerment**: Centering patient journeys in the development and delivery of treatments [4] Unmet Medical Needs - **Alzheimer's Disease Psychosis**: Approximately 800,000-850,000 patients in the U.S. experience hallucinations or delusions, with no approved treatments available [14][17] - **Lewy Body Dementia**: A significant portion of patients (50%-70%) experience psychosis, highlighting the need for effective therapies [17][18] - **Major Depressive Disorder**: 21 million adults diagnosed in the U.S., with only 9 million currently treated, indicating a large market opportunity [19][20] Conclusion - **Future Outlook**: ACADIA is positioned for growth with a strong pipeline and financial health, aiming to address significant unmet needs in neurological and rare diseases while expanding its market presence [24]