Financial Data and Key Metrics Changes - For the year ended December 31, 2024, the company reported revenues of $152.3 million, a decrease of $14.5 million from $166.8 million in 2023 [27] - For Q4 2024, revenues were $22.8 million, down $8.1 million from $30.9 million in Q4 2023 [27] - The net loss for the year was approximately $80.9 million, or $3 per diluted share, compared to a net loss of $29.7 million, or $1.12 per diluted share in 2023 [31] - Cash and cash equivalents were $293.9 million as of December 31, 2024, down from $348.9 million a year earlier [32] Business Line Data and Key Metrics Changes - The KOSTAIVE vaccine program achieved European Commission approval, with a reported gross profit share of approximately $28 million for Q4 2024 [24] - Research and development expenses for the year were $195.2 million, up from $192.1 million in 2023, driven by higher clinical trial costs [28] - General and administrative expenses remained relatively stable at $52.8 million for the year, compared to $52.9 million in 2023 [30] Market Data and Key Metrics Changes - The company anticipates increased burn rates in the next two years due to ongoing clinical trials for cystic fibrosis (CF) and ornithine transcarbamylase (OTC) programs [33] - The cash runway is expected to extend until the end of Q1 2027, despite the anticipated decline in development milestones from the COVID program [33] Company Strategy and Development Direction - The company is focused on advancing its self-amplifying mRNA platform pipeline, with ongoing studies for ARCT-2304 (influenza) and ARCT-032 (cystic fibrosis) [12][15] - The strategic partnership with CSL Seqirus is crucial for the KOSTAIVE vaccine's development and commercialization [25] - The company aims to differentiate its mRNA therapeutics through proprietary delivery technologies and unique mRNA sequences [42] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about the upcoming year, highlighting the potential for multiple clinical data readouts and continued development of vaccine programs [34] - The approval of KOSTAIVE is seen as a transformative milestone, positioning the company for future growth [35] - Management acknowledged the competitive landscape in cystic fibrosis treatments and emphasized the unique advantages of their mRNA technology [106] Other Important Information - The company appointed Dr. Moncef Slaoui as Chair designate, bringing significant industry experience to the board [20] - The company is preparing for the U.S. BLA filing for KOSTAIVE anticipated later in 2025 [10] Q&A Session Summary Question: What is the cadence of development milestones within the CSL collaboration? - Management indicated that milestones will continue to be received throughout the year, with specific updates expected in the first quarter call [40] Question: How does the CF program differentiate from competitors? - Management highlighted differences in mRNA technology, delivery systems, and manufacturing processes as key competitive advantages [42] Question: What is the expected size of the CF trial cohort? - The Phase II trial is expected to involve approximately 12 participants, with flexibility to increase that number [48] Question: What are the next steps for KOSTAIVE commercialization in Europe? - Management stated that CSL is leading the commercialization process, and specific details will be provided as they become available [78] Question: What safety monitoring parameters are in place for the CF study? - A data and safety monitoring committee is overseeing safety and tolerability, with thresholds for adverse events established [84] Question: What is the expected visibility into orders for KOSTAIVE in 2025? - Management noted that visibility into orders will depend on Meiji's guidance, with expectations for updates as the year progresses [63]

Financial Position and Performance - As of December 31, 2024, the company had an accumulated deficit of $448.8 million[208]. - The company has not generated any revenue from product sales since inception and relies on collaboration and grant revenue[213]. - The company expects to continue incurring significant losses and increasing operating expenses for the foreseeable future[210]. - The company had unrestricted cash and cash equivalents of $237.0 million as of December 31, 2024, expected to fund operations for the near future[216]. - The company anticipates needing to raise additional capital in the future, which may not be available on acceptable terms[216]. - The company has not declared or paid any cash dividends on its common stock and anticipates retaining future earnings for business development[341]. - Significant additional capital will be needed in the future, which may lead to dilution of existing shareholders' ownership[348]. Dependence on Collaboration and Competition - The company is dependent on collaboration partners, particularly CSL Seqirus, for the commercialization of its products, which are currently only approved in Japan and Europe[207]. - The company has entered into a collaboration agreement with CSL Seqirus for the research, manufacture, and global commercialization of self-amplifying mRNA vaccines against COVID-19 and other infectious diseases[226]. - The company faces significant competition in the vaccine market, with competitors having greater financial and scientific resources[205]. - The company faces significant competition in the COVID-19 vaccine market, with competitors like Pfizer and Moderna already having vaccinated billions of people globally[231]. - The potential market opportunity for KOSTAIVE may shrink if the prevalence of COVID-19 declines and public concern about the virus decreases[227]. - The success of KOSTAIVE's commercialization in Japan may be hindered by competition, pricing, and regulatory requirements for local production[230]. - The acceptance of product candidates by the medical community is crucial for commercial success, influenced by factors such as clinical safety, efficacy, and pricing[266]. Regulatory and Compliance Risks - The company has identified a material weakness in its internal control over financial reporting, which could affect its ability to report financial results accurately[210]. - Regulatory authorities may impose restrictions on product approval, including additional clinical trials or post-marketing surveillance requirements[259]. - The company faces risks of delays in obtaining marketing approval due to potential disagreements with regulatory authorities regarding trial designs and data interpretations[256]. - Compliance with environmental, health, and safety laws is critical, as violations could result in significant fines or penalties[263]. - The company is subject to audits by U.S. Government agencies, and negative audit outcomes could preclude new contracts or lead to contract terminations[331]. - The company may face substantial penalties for violations of various healthcare laws, including the federal Anti-Kickback Statute and the False Claims Act, which could adversely affect operations[321]. - Noncompliance with healthcare fraud and abuse laws could result in criminal sanctions, civil penalties, and diminished profits[318]. Operational and Development Challenges - The company has devoted most of its financial resources to research and development, which may increase expenses significantly as it advances its product candidates[209]. - Clinical trials are expensive and can take many years to complete, with significant risks of failure at any stage[242]. - Delays in clinical trials can lead to increased product development costs and may shorten exclusive commercialization rights[245]. - The limited number of patients for certain rare diseases may delay or prevent clinical studies, affecting the timeline for regulatory approval[249]. - Approximately 8,000 patients in the developed world suffer from late-onset OTC deficiency, highlighting the challenges in patient recruitment for clinical studies[248]. - Manufacturing issues may lead to increased product and regulatory approval costs, potentially delaying commercialization[265]. - The company relies on outside contractors for clinical studies and product manufacturing, which poses risks of delays and regulatory issues[286]. - The company relies on contract research organizations (CROs) for clinical trials, and any unsatisfactory performance could harm business operations and delay regulatory approvals[291]. Intellectual Property and Legal Risks - The company faces risks related to intellectual property, including potential infringement claims that could delay product development and commercialization[302]. - The company may need to obtain licenses for necessary intellectual property to advance research and commercialization, and failure to do so could significantly harm its business[307]. - The company may face substantial litigation expenses related to protecting its intellectual property rights, which could distract management and impact financial resources[308]. - The U.S. government may exercise "march-in" rights under the Bayh-Dole Act, which could adversely affect the company's business and financial condition[312]. Human Resources and Management - The company had approximately 176 employees as of December 31, 2024, and plans to expand its workforce to enhance managerial, scientific, operational, and commercial resources[314]. - Competition for skilled personnel is intense, and the company has experienced a high turnover rate, which could impede research and development progress[315]. - Future growth may impose significant additional responsibilities on management, potentially leading to operational mistakes and loss of business opportunities[314]. Market and Economic Factors - The new U.S. presidential administration may implement policies that could negatively impact the biotechnology industry and the company's ability to raise financing[258]. - Legislative and regulatory changes in the healthcare system may negatively impact reimbursement for drug products[277]. - Adequate coverage and reimbursement from healthcare payors are critical for the profitability of future products[275]. - The market price of the common stock has been highly volatile, influenced by factors such as clinical trial results and regulatory approvals[342]. - The company entered into a Sales Agreement allowing for the sale of up to $200 million in common stock, but no shares have been sold under this agreement as of the current date[350]. - The company must comply with Nasdaq's continued listing requirements, including a minimum bid price of $1.00 per share, to avoid potential delisting[351]. Risk Management and Security - Cybersecurity risks could lead to unauthorized access to sensitive data, resulting in fines, damages, and reputational harm[325]. - The company is vulnerable to natural disasters and may not carry sufficient business interruption insurance, potentially affecting operations[327]. - The company may need to allocate resources strategically, potentially missing out on more profitable opportunities[261]. - Undesirable side effects from product candidates could lead to halted clinical trials and negatively impact market acceptance[250]. - Changes to drug product presentations could delay commercialization timelines and increase costs[240]. - Supply chain disruptions for raw materials could significantly delay the development and commercialization of product candidates[287]. - Switching manufacturers or suppliers may incur substantial costs and result in delays in clinical and commercial timelines[288].

Revenue Performance - For Q4 2024, Arcturus reported revenue of $22.8 million, a decrease of 26.2% from $30.9 million in Q4 2023, attributed to lower milestone achievements from the CSL agreement[5] - For the full year 2024, revenue was $152.3 million, down 8.7% from $166.8 million in 2023, with decreased milestone achievements offset by increased BARDA revenue[6] - Total revenue for 2024 was $152.31 million, a decrease of 8.4% from $166.80 million in 2023[18] - Collaboration revenue decreased to $138.39 million in 2024, down 12.2% from $157.75 million in 2023[18] Operating Expenses - Total operating expenses for Q4 2024 were $56.2 million, up 14.4% from $49.1 million in Q4 2023, while total operating expenses for the year were $248.0 million, slightly up from $245.0 million in 2023[7] - Total operating expenses for 2024 were $247.98 million, an increase of 1.2% from $245.00 million in 2023[18] Research and Development - Research and development expenses for Q4 2024 were $43.8 million, an increase of 19.7% from $36.6 million in Q4 2023, driven by higher clinical trial costs[8] - Research and development expenses increased to $195.16 million in 2024, up 1.6% from $192.13 million in 2023[18] Net Loss and Earnings - Arcturus reported a net loss of approximately $30.0 million, or ($1.11) per diluted share, for Q4 2024, compared to a net loss of $11.7 million, or ($0.44) per diluted share, in Q4 2023[10] - Net loss for 2024 was $80.94 million, compared to a net loss of $29.73 million in 2023[18] - Basic and diluted loss per share for 2024 was $3.00, compared to a loss of $1.12 per share in 2023[18] - The company reported a comprehensive loss of $80.94 million for 2024, compared to a comprehensive loss of $29.73 million in 2023[18] Assets and Liabilities - The company had cash, cash equivalents, and restricted cash of $293.9 million as of December 31, 2024, down from $348.9 million on December 31, 2023[11] - Total assets decreased to $344.07 million in 2024, down 20% from $429.40 million in 2023[17] - Total liabilities decreased to $103.09 million in 2024, down 31.5% from $150.89 million in 2023[17] - Stockholders' equity decreased to $240.98 million in 2024, down 13.5% from $278.51 million in 2023[17] Future Expectations and Developments - Arcturus expects to provide interim data from the Phase 2 studies of ARCT-032 and ARCT-810 by the end of Q2 2025[2] - KOSTAIVE® received European Commission approval in February 2025, valid in all 27 EU member states and 3 EEA countries, based on positive clinical data[4] - The company initiated the Phase 1 study of ARCT-2304 for H5N1 pandemic influenza in December 2024, with interim data expected in H2 2025[4] - Arcturus anticipates a cash runway extending until the end of Q1 2027, supported by future milestone payments from CSL[11]

Core Insights - The European Commission has granted marketing authorization for KOSTAIVE, a self-amplifying mRNA COVID-19 vaccine developed by CSL and Arcturus Therapeutics, marking a significant advancement in vaccine technology [1][2][3] - KOSTAIVE demonstrates superior immunogenicity and antibody persistence for up to 12 months post-vaccination compared to conventional mRNA COVID-19 vaccines [1][3] Company Overview - CSL is a global biotechnology company with a diverse portfolio of lifesaving medicines, including treatments for hemophilia, immune deficiencies, and vaccines for influenza, employing 32,000 people and operating in over 100 countries [5] - Arcturus Therapeutics, founded in 2013, specializes in mRNA medicines and vaccines, with a focus on self-amplifying mRNA technology and a robust pipeline that includes candidates for various diseases [7][8] Regulatory Milestones - The approval of KOSTAIVE follows a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) on December 12, 2024, allowing its use across all EU member states and EEA countries [2][3] Clinical Data - KOSTAIVE's approval is based on positive clinical data from integrated phase 1/2/3 studies, demonstrating its efficacy and tolerability, as well as phase 3 booster trials showing higher immunogenicity compared to conventional mRNA vaccines [3][4]

Company Overview - Arcturus Therapeutics (NASDAQ: ARCT) is actively evaluating LUNAR-CF [ARCT-032] for the treatment of patients with Cystic Fibrosis (CF) [2] Product Development - The company is focused on developing LUNAR-CF, which shows promise in treating CF, indicating a potential advancement in therapeutic options for this condition [2]

Financial Data and Key Metrics Changes - For Q3 2024, the company reported revenues of $41.7 million, a slight decrease from $45.1 million in Q3 2023, primarily due to a decrease in CSL revenue from $35 million in Q3 2023 to $25 million in Q3 2024, offset by increased revenue from the BARDA agreement [29] - Total operating expenses for Q3 2024 were $52.4 million, down from $64.5 million in Q3 2023, while total operating expenses for the nine months ended September 30, 2024, were $191.8 million compared to $195.9 million for the same period in 2023 [30] - The net loss for Q3 2024 was approximately $6.9 million or $0.26 per diluted share, compared to a net loss of $16.2 million or $0.61 per diluted share for Q3 2023 [32] - Cash, cash equivalents, and restricted cash were $294.1 million as of September 30, 2024, down from $348.9 million as of December 31, 2023 [33] Business Line Data and Key Metrics Changes - The launch of KOSTAIVE, the COVID-19 vaccine, in Japan represents a significant milestone as the first commercial product in the company's history, with a $25 million commercial milestone received for the first sale [25][26] - The company continues to collect clinical data for its proprietary STARR mRNA platform, with positive Phase 3 results for ARCT-2303, a derivative of KOSTAIVE, meeting all primary and key secondary study objectives [12][13] Market Data and Key Metrics Changes - The company is working with Meiji, Japan's leading flu vaccine company, to effectively launch KOSTAIVE, with expectations to sell approximately 4.5 million vaccines during the season [40] - The European Medicines Agency is reviewing the KOSTAIVE marketing authorization application, with a CHMP opinion expected next month [10] Company Strategy and Development Direction - The company plans to file a BLA for KOSTAIVE in the first half of next year, supported by positive results from multiple Phase 3 studies [11] - The strategic review process conducted by JP Morgan generated interest from financial and strategic participants, which will benefit the company and its manufacturing joint venture, Arcalis, in the future [28] - The company has decided to expand its manufacturing product line with Arcalis to include respiratory mRNA therapeutics and transfer its cystic fibrosis manufacturing process technology to Arcalis [28] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the ongoing development of the COVID and flu programs, expecting to achieve multiple near-term value-creating milestones [35] - The cash runway is expected to extend into the first quarter of fiscal year 2027, not including contributions from KOSTAIVE vaccine sales in Japan [34] Other Important Information - The company is on track to share interim Phase 2 proof of concept data for its cystic fibrosis program in the first half of 2025 [21][35] - The company has received clearance for an investigational new drug application for ARCT-032, an inhaled mRNA therapeutic for cystic fibrosis, enabling the initiation of a Phase 2 study [19] Q&A Session Summary Question: Can you provide more details on the commercial launch of KOSTAIVE in Japan? - Management indicated that Meiji plans to sell approximately 4.5 million vaccines during the season, with a full launch expected by December [40][41] Question: What is the size and design of the Phase 2 cystic fibrosis study? - The study will evaluate multiple doses in an open-label format, focusing on lung function improvement [44][45] Question: What are the expectations for the interim Phase 2 data for the OTC deficiency study? - The U.S. study is expected to be similar in size to the European study, with interim data to be shared in the first half of 2025 [42][44] Question: What is the timeline for EMA approval of KOSTAIVE? - A CHMP decision is anticipated in December, leading to formal approval in Q1 2025 [63] Question: Will the company report on manufacturing orders from Meiji? - The company cannot comment on specific manufacturing orders as that will be up to Meiji and CSL to articulate [64] Question: What are the key differentiators of ARCT-032 compared to competitors? - The company highlighted its unique delivery technology and the purity of its mRNA as key differentiators [66][68]

Company Performance - Arcturus Therapeutics reported a quarterly loss of $0.26 per share, significantly better than the Zacks Consensus Estimate of a loss of $0.70, representing an earnings surprise of 62.86% [1] - The company posted revenues of $41.67 million for the quarter ended September 2024, missing the Zacks Consensus Estimate by 15.23% and down from $45.14 million a year ago [2] - Over the last four quarters, Arcturus has surpassed consensus EPS estimates four times and topped consensus revenue estimates two times [2] Stock Movement and Outlook - Arcturus Therapeutics shares have declined approximately 41.9% since the beginning of the year, contrasting with the S&P 500's gain of 24.3% [3] - The company's earnings outlook will be crucial for future stock performance, with current consensus EPS estimate at $0.28 on revenues of $81.28 million for the coming quarter [4][7] - The estimate revisions trend for Arcturus is mixed, resulting in a Zacks Rank 3 (Hold), indicating expected performance in line with the market [6] Industry Context - The Medical - Biomedical and Genetics industry, to which Arcturus belongs, is currently ranked in the top 36% of over 250 Zacks industries, suggesting a favorable industry outlook [8] - Empirical research indicates a strong correlation between near-term stock movements and trends in earnings estimate revisions, which can impact Arcturus's stock performance [5]

Financial Performance - Total revenue for the three months ended September 30, 2024, was $41,673,000, a decrease of 7.5% compared to $45,140,000 for the same period in 2023[11]. - Collaboration revenue for the nine months ended September 30, 2024, was $117,389,000, down 11.4% from $132,670,000 in the prior year[11]. - For the nine months ended September 30, 2024, Arcturus reported a net loss of $50.9 million, compared to a net loss of $18.0 million for the same period in 2023, indicating a significant increase in losses[13]. - Revenue for the three months ended September 30, 2024, was $41.673 million, a decrease of $3.467 million or 7.7% compared to $45.140 million for the same period in 2023, primarily due to lower milestone achievements from the CSL agreement[69]. - For the nine months ended September 30, 2024, revenue was $129.544 million, down $6.4 million or 4.7% from $135.944 million in the same period in 2023, attributed to timing and value of milestone achievements[70]. Expenses and Losses - Net loss for the three months ended September 30, 2024, was $6,903,000, compared to a net loss of $16,222,000 for the same period in 2023, reflecting a 57.5% improvement[11]. - Operating expenses for the three months ended September 30, 2024, totaled $52.410 million, a decrease of $12.044 million or 18.7% compared to $64.454 million in the same period in 2023[72]. - Research and development expenses for the three months ended September 30, 2024, were $39,134,000, down 23.3% from $51,077,000 in the same period last year[11]. - Research and development expenses for Q3 2024 were $39.1 million, a decrease of 23.4% from $51.1 million in Q3 2023[73]. - The company expects substantial research and development costs to continue as its pipeline progresses over the next several years[73]. Assets and Liabilities - Total current assets decreased to $330,821,000 as of September 30, 2024, from $386,590,000 at December 31, 2023, representing a decline of 14.5%[10]. - Total liabilities decreased to $108,788,000 as of September 30, 2024, from $150,889,000 at December 31, 2023, a reduction of 28%[10]. - Cash and cash equivalents decreased to $237,178,000 as of September 30, 2024, from $292,005,000 at December 31, 2023, a decline of 18.8%[10]. - Total stockholders' equity as of September 30, 2024, was $261,866,000, down from $278,513,000 at December 31, 2023, a decrease of 5.9%[10]. - Cash and cash equivalents, including restricted cash, totaled $294.1 million as of September 30, 2024, down from $369.1 million at the end of September 2023[13]. Funding and Capital - The company has sufficient working capital to fund operations for at least the next twelve months, although future funding remains uncertain[17]. - The company may need to raise additional capital through equity or debt financing, which could have a dilutive effect on existing shareholders[86]. - The company expects to continue incurring additional losses in the long term, requiring additional capital to fund operations[88]. - The company anticipates that its current cash position will be sufficient to meet cash requirements for at least the next twelve months[88]. - The remaining available funding from the BARDA grant, net of revenue earned, was $41.6 million as of September 30, 2024[35]. Product Development and Collaborations - The company received marketing authorization for its COVID-19 vaccine, ARCT-154 (KOSTAIVE), in Japan for adults aged 18 and older, marking a significant milestone in its product development[14]. - The Company received a $200 million upfront payment from CSL Seqirus and is eligible for over $1.3 billion in development milestones and up to $3 billion in commercial milestones related to vaccine commercialization[32]. - The Company achieved a $25 million development milestone related to the CSL Collaboration Agreement upon the first commercial sale of KOSTAIVE following regulatory approval in Japan[32]. - The collaboration with CSL Seqirus focuses on developing self-amplifying mRNA vaccines for COVID-19 and other respiratory diseases, leveraging both companies' expertise[51]. - The company is expanding the Phase 2 clinical program of ARCT-810 to the U.S. with an open-label, multiple-dose study currently recruiting patients[63]. Regulatory and Compliance - The company has identified material weaknesses in internal control over financial reporting, particularly in IT general controls and revenue recognition[93]. - The company plans to implement remediation activities to address identified material weaknesses by the end of fiscal year 2024[94]. - The financial statements for the fiscal quarter ended September 30, 2024, were prepared in Inline XBRL format, indicating compliance with modern reporting standards[101]. - The company is committed to transparency and regulatory compliance, as shown by the certifications filed under the Securities Exchange Act of 1934[31]. Strategic Outlook - The company is committed to executing milestones within the CSL Collaboration Agreement to transition to profitability[86]. - Future capital requirements are difficult to forecast and will depend on various factors, including the development of vaccine candidates and strategic alliances[88]. - The company is actively pursuing market expansion strategies, as evidenced by multiple amendments to collaboration agreements with key partners[31]. - Arcturus Therapeutics is positioned for future growth through strategic partnerships and financial agreements that support its operational goals[31].

Financial Performance - Arcturus reported revenue of $41.7 million for Q3 2024, a decrease of $3.5 million from $45.2 million in Q3 2023, primarily due to lower milestone achievements from the CSL agreement[13] - Total revenue for the three months ended September 30, 2024, was $41,673,000, a decrease of 7.5% compared to $45,140,000 for the same period in 2023[23] - Collaboration revenue for the nine months ended September 30, 2024, was $117,389,000, down 11.5% from $132,670,000 in the prior year[23] - Arcturus reported a net loss of approximately $6.9 million, or ($0.26) per diluted share, for Q3 2024, compared to a net loss of $16.2 million, or ($0.61) per diluted share, in Q3 2023[18] - Net loss for the three months ended September 30, 2024, was $6,903,000, compared to a net loss of $16,222,000 for the same period in 2023, representing a 57.5% improvement[23] Expenses - Research and development expenses for Q3 2024 were $39.1 million, down from $51.1 million in Q3 2023, driven by decreased manufacturing costs for the COVID program[16] - Total operating expenses for Q3 2024 were $52.4 million, a decrease from $64.5 million in Q3 2023[15] - Research and development expenses for the three months ended September 30, 2024, were $39,134,000, a decrease of 23.3% from $51,077,000 in the same period last year[23] Cash and Assets - Cash, cash equivalents, and restricted cash were $294.1 million as of September 30, 2024, down from $348.9 million on December 31, 2023[19] - Total current assets decreased to $330,821,000 as of September 30, 2024, from $386,590,000 at December 31, 2023, reflecting a decline of 14.5%[22] - Cash and cash equivalents were $237,178,000 as of September 30, 2024, down from $292,005,000 at December 31, 2023, a decrease of 18.8%[22] - Total liabilities decreased to $108,788,000 as of September 30, 2024, down from $150,889,000 at December 31, 2023, indicating a reduction of 28%[22] - The accumulated deficit increased to $(418,802,000) as of September 30, 2024, from $(367,866,000) at December 31, 2023[22] - Total stockholders' equity decreased to $261,866,000 as of September 30, 2024, down from $278,513,000 at December 31, 2023, a decline of 6%[22] Product Development and Milestones - The company achieved a $25 million commercial milestone with the first sale of KOSTAIVE® in Japan[6] - KOSTAIVE® demonstrated superior immunogenicity compared to the conventional mRNA vaccine COMIRNATY® for up to one year at one-sixth the dose[8] - The company expects to share interim Phase 2 proof-of-concept data for ARCT-032 and ARCT-810 in the first half of 2025[2] - The company anticipates another milestone related to potential European approval for KOSTAIVE® in Q1 2025[2] Future Outlook - The cash runway is expected to extend through the first quarter of fiscal year 2027 based on the current pipeline and programs[19]

We expect investors to focus on the launch plans of Arcturus Therapeutics Holdings Inc.’s (ARCT) self-amplifying mRNA (sa-mRNA) COVID-19 vaccine, Kostaive (ARCT-154), and updates on the pipeline when it reports third-quarter 2024 results on Nov. 7, after market close.The Zacks Consensus Estimate for revenues is pegged at $49.2 million.Stay up-to-date with all quarterly releases: See Zacks Earnings Calendar.Let's see how things might have shaped up for the quarter to be reported.Factors to Note Ahead of ARCT ...