Beam Therapeutics Inc. (NASDAQ:BEAM)  is among the Growth Stock Portfolio: 12 Stock Picks By Cathie Wood. Bernstein Maintains an Outperform Rating on Beam Therapeutics Inc. (BEAM) On January 7, 2026, TheFly reported that Bernstein maintained its Outperform rating. It increased its price objective for Beam Therapeutics Inc. (NASDAQ:BEAM) from $37 to $41. The company’s Alpha-1 Antitrypsin Deficiency program received a favorable regulatory update before the change. The latest regulatory action was Bernstein ...

Cathie Wood-led Ark Invest made notable trades on Wednesday, involving Netflix Inc. (NASDAQ:NFLX) , Tempus AI Inc. (NASDAQ:TEM) , and Pinterest Inc. (NYSE:PINS) . These trades come amidst significant market developments for each company, providing a strategic opportunity for Ark’s investment strategy.The Netflix TradeARK Next Generation Internet ETF (BATS:ARKW) acquired 83,368 shares of Netflix Inc. The purchase follows Netflix’s recent earnings report, which showed mixed results. Despite beating earnings-p ...

Company Overview - Beam Therapeutics aims to provide lifelong cures for patients with serious diseases through gene editing for both rare and common disorders, potentially leading to one-time curative therapies with lasting effects [3]. Recent Developments - In late 2024, Beam Therapeutics revealed significant data on base editing for severe sickle cell disease, demonstrating dramatic results in patient outcomes [4]. - In March, the company published its first data on base editing for alpha-1 antitrypsin deficiency using the BEAM-302 approach, marking a shift to in vivo editing [4]. Technology and Vision - The company emphasizes the power of predictability in its technology, which is designed to create a wide range of medicines over time, reflecting a remarkable year for base editing advancements [2][3].

Beam Therapeutics Conference Call Summary Company Overview - **Company**: Beam Therapeutics (NasdaqGS:BEAM) - **Industry**: Biotechnology, specifically gene editing for rare and common disorders Key Points and Arguments Vision and Technology - Beam Therapeutics aims to provide lifelong cures for patients with serious diseases through gene editing, focusing on one-time curative therapies with lasting effects [2][4] - The company utilizes base editing technology, which allows precise single-letter changes in genes without creating double-stranded breaks, leading to predictable and durable outcomes [4][5] Recent Achievements - In 2024, Beam presented significant data on base editing for severe sickle cell disease, demonstrating dramatic results [2][3] - The first data for base editing in alpha-1 antitrypsin deficiency (Beam 302) was published, showcasing the ability to rewrite a broken gene back to normal [3][12] Clinical Programs - **Beam 302**: Aimed at correcting the single-letter misspelling in the SERPINA1 gene responsible for alpha-1 antitrypsin deficiency, with the goal of restoring normal protein levels and addressing both lung and liver issues [15][16] - **Ristacel**: Targeting sickle cell disease, with a focus on achieving deeper resolution of the disease and improving patient outcomes [22][23] Regulatory Progress - Beam has received RMAT designation from the FDA, allowing for accelerated approval pathways for its therapies [18][19] - The company anticipates submitting a Biologics License Application (BLA) for Ristacel by the end of 2026 [29] Financial Position - Beam reported having $1.25 billion in cash at the end of the year, providing a runway into 2029 for the development and commercialization of its therapies [10][11] Market Potential - The company believes that its therapies will reduce lifetime healthcare costs and improve patient outcomes, making them attractive to payers [7][8] - There is significant patient interest and a growing number of treatment centers prepared to administer Beam's therapies [25][27] Future Directions - Beam plans to expand its pipeline with additional liver-targeted genetic disease programs and continue advancing its hematology franchise [33][34] - The company is also focusing on in vivo delivery methods to enhance scalability and reach more patients [30][31] Additional Important Information - Beam's base editing technology is adaptable and scalable, with a strong emphasis on manufacturing efficiency [9][43] - The company has established partnerships that have generated over $900 million in non-dilutive funding, enhancing its research capabilities [32] - Beam is committed to addressing unmet medical needs in rare diseases, with a focus on both therapeutic impact and commercial viability [56] This summary encapsulates the key points discussed during the conference call, highlighting Beam Therapeutics' innovative approach to gene editing, recent achievements, regulatory progress, financial strength, and future plans in the biotechnology sector.

Financial Position and Runway - Beam had $1.25 billion in cash as of December 31, 2025, inclusive of $255.1 million proceeds from the Orbital acquisition[16] - The company's operating runway is expected into 2029, funding through risto-cel launch and execution of BEAM-302 pivotal development plan[16,60] Program Advancements and Regulatory Alignment - Beam achieved first human proof of concept for in vivo gene correction with BEAM-302 in 2025[17] - Alignment was reached with the FDA on a potential accelerated approval pathway for BEAM-302 in AATD, with primary endpoint expected to be based on AAT biomarkers evaluated over 12 months[27] - The company plans to submit the risto-cel BLA package as early as YE 2026[45,60] Clinical Data and Trial Updates - BEAM-302 Phase 1/2 trial has dosed >25 patients across cohorts to date, with updated clinical data expected by the end of first quarter 2026[25,60] - Initial clinical data for BEAM-301 is planned to be reported by YE 2026[31,60] - BEACON results for risto-cel in SCD show HbF levels >60% and HbS levels <40%, comparable to sickle trait, with resolution of anemia and normalized or improved markers of hemolysis and oxygen delivery[37] - At Day 28, BEAM-302 showed mean total AAT in circulation at 12.4µM, mean % change in Z-AAT at -78%, and corrected M-AAT reached >90% of total circulating AAT[24] Strategic Initiatives - Beam completed a $500 million financing and runway extension into 2029[17] - The company intends to pursue an accelerated approval pathway for BEAM-302 based on FDA feedback to date[26]

Core Insights - The article highlights the background and achievements of Brendan, who has a strong academic and professional foundation in organic synthesis and biotechnology [1] Group 1: Background and Education - Brendan completed a Ph.D. at Stanford University in organic synthesis in 2009 [1] - He worked for Merck, a major pharmaceutical company, from 2009 to 2013 [1] Group 2: Professional Experience - Brendan has experience in biotech, including roles in start-ups such as Theravance and Aspira before joining Caltech [1] - He was the first employee and co-founder of 1200 Pharma, which spun out of Caltech and secured significant investment in the eight-figure range [1] Group 3: Investment Focus - Brendan remains an avid investor, particularly focused on market trends and biotechnology stocks [1]

Group 1 - Brendan, a Pennsylvanian, completed a Ph.D. at Stanford University in organic synthesis in 2009 [1] - He worked for Merck from 2009 to 2013 and has experience in biotech startups including Theravance and Aspira before joining Caltech [1] - Brendan is the first employee and co-founder of 1200 Pharma, which spun out of Caltech and secured major investments in the 8 figures [1] - He remains an avid investor focused on market trends, particularly in biotechnology stocks [1]

Core Insights - Beam Therapeutics' shares increased by 22.3% following the announcement of strategic priorities and expected milestones for its gene therapy pipeline candidates aimed for 2026 [1][8] Pipeline Developments - The lead candidate, BEAM-302, is in an open-label phase I/II study for treating alpha-1 antitrypsin deficiency (AATD), with over 25 patients treated so far [2][4] - AATD is a genetic disorder leading to early emphysema and liver disease, with no current curative treatments available [3] - The company has aligned with the FDA on a potential accelerated approval pathway for BEAM-302 based on 12-month AAT biomarker data, planning to enroll around 50 additional patients [4][5] - Updated data from the phase I/II study and next steps for BEAM-302 are expected by the end of Q1 2026 [5] - BEAM-301 is also in a phase I/II study for glycogen storage disease type 1a (GSD1a), with initial data expected later in 2026 [6] Financial Position - Beam Therapeutics ended 2025 with approximately $1.25 billion in cash and equivalents, providing financial flexibility to support ongoing clinical programs and anticipated expenses through 2029 [13] Market Performance - Over the past six months, Beam Therapeutics' shares have increased by 59.1%, outperforming the industry average increase of 21% [7]

智通财经APP注意到，Beam Therapeutics (BEAM.US) 股价在周一大幅上涨超20%，截至收盘，该股涨 22.29%，报33.69美元，此前该公司发布了关于持续致力于建立可持续、可预测模式以推进精准基因药 物开发的最新进展。 该公司强调了其肝脏靶向基因疾病和血液学特许经营项目的近期进展，概述了 2026 年的战略重点，并 指出预期的运营资金支持期限已得到延长，足以支持其各项计划。 截至 2025 年底，公司持有的现金、现金等价物及有价证券估值约为 12.5 亿美元;预计运营资金支持期 限将延长至 2029 年，这将为 risto-cel 的预期上市以及 BEAM-302 关键开发计划的执行提供有力支持。 此外，该公司肝脏靶向基因疾病特许经营项目的扩张正在进行中， ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 11, 2026 Registrant's Telephone Number, Including Area Code: 857 327-8775 (Former Name or Former Address, if Changed Since Last Report) Beam Therapeutics Inc. (Exact name of Registrant as Specified in Its Charter) (State or Other Jurisdiction of Incorporation) Delaware 001-39208 81-5238 ...