声明：市场有风险，投资需谨慎。本文为AI基于第三方数据生成，仅供参考，不构成个人投资建议。 本文源自：市场资讯 作者：公告君 有投资者在互动平台向百济神州提问："公司作为一线创新药企，在近年最热前沿领域双抗、ADC及双 抗ADC都没有部局，很快将被超越。目前君实生物拥有双抗、ADC、双抗ADC，股价只有二三百亿， 处于超级低估状态，有国际MNC打算在港股举牌收购君实生物，建议公司先下手为强，MNC购买 PD1/VEGF双抗都要花400-500亿，现在只要花200-300亿收购君实生物，就可以把国际最前沿的双抗、 ADC及双抗ADC一并收入囊中，望采纳。谢谢！" 针对上述提问，百济神州回应称："尊敬的投资者，您好！公司正在依托于业内规模最大的肿瘤学临床 前研究团队之一，以及具备战略优势的全球内部临床开发和生产团队，加速将创新药物惠及世界各地的 患者。公司研究团队在小分子抑制剂和生物制剂设计与开发方面具备深厚的专业优势，并在靶向蛋白降 解剂、多特异性抗体，以及抗体偶联药物（ADC）等关键领域不断深化布局，持续展现出强劲的创新 动力。在过去的18个月中，公司已将15个新分子实体推进至临床开发阶段，涵盖多种治疗方式。 ...

Investment Rating - The report indicates a significant acceleration in BD (Business Development) overseas for Chinese innovative drugs, suggesting a positive investment outlook for the industry [3]. Core Insights - The number of BD projects, upfront payments, and total amounts for Chinese pharmaceutical companies significantly increased in 2025, with 165 projects, over $7.03 billion in upfront payments (up 226.8% year-on-year), and a total amount of $136.68 billion (up 192.2% year-on-year) [2][7]. - The report highlights a focus on dual antibodies (双抗), antibody-drug conjugates (ADC), GLP-1 receptor agonists (GLP1RA), and small nucleic acids as key areas for BD overseas [2][3]. Summary by Sections BD Project Growth - In 2025, the quarterly breakdown of BD projects shows 41, 43, 30, and 51 projects in Q1, Q2, Q3, and Q4 respectively, with significant year-on-year increases [2][7]. - Upfront payments for each quarter were $0.9 billion, $2.0 billion, $1.86 billion, and $2.27 billion, reflecting substantial growth rates [2][7]. Outbound BD Models - The predominant model for BD remains license in/out, while the NewCo/Co-CoJV model is gaining attention, with limited successful cases of independent commercialization [2][12][13]. - In 2025, MNCs (Multinational Corporations) accounted for $4.71 billion in upfront payments, representing 67% of total BD upfront payments [12]. Key Drug Categories - Dual antibodies saw a remarkable increase, with $3.5 billion in upfront payments (up 414.7%) and a total amount of $21.85 billion (up 361.5%) in 2025 [2][18]. - ADCs emerged as a significant focus, with $1.63 billion in upfront payments (up 676.2%) and a total amount of $21.13 billion (up 390.6%) [2][26]. - GLP-1RA projects achieved $470 million in upfront payments, marking a 109.8% increase, with a total amount of $9.6 billion [2]. NewCo Model - The NewCo model has facilitated overseas BD, with a total of $350 million in upfront payments and $13.74 billion in potential total amounts from 2023 to 2025 [17]. - In 2025, NewCo projects secured $110 million in upfront payments and $4.76 billion in potential total amounts [17]. Clinical Development Stages - Approximately 62% of molecules were in early clinical stages (pre-clinical to before Phase II) at the time of BD, indicating a trend towards early-stage licensing [8][9].

截至2026年1月20日 10:03，中证港股通医药卫生综合指数(930965)成分股方面涨跌互现，时代天使领涨 4.83%，映恩生物-B上涨1.86%，联邦制药上涨1.23%；药明康德领跌。港股医药ETF(159718)最新报价 0.96元。 消息面上，医药魔方NextPharma数据库显示，截至2025年12月31日，中国创新药商务拓展（BD）出海 授权全年交易总金额达到1356.55亿美元，首付款70亿美元，交易总数量达到157笔，远超2024年全年 519亿美元和94笔，各个维度的数据统计均达到了历史新高。 华鑫证券表示，2025年中国创新药BD出海授权交易总金额达1356.55亿美元，首付款70亿美元，数量达 157起，均创历史新高；进入2026年开局延续强劲势头，荣昌生物PD-1/VEGF双抗RC148获艾伯维6.5亿 美元首付款授权，宜联生物与罗氏就B7H3靶向ADC达成合作。此外，葛兰素史克Bepirovirsen治疗慢性 乙肝III期研究取得积极结果，Arrowhead公布RNAi疗法在减重领域的新进展，小核酸药物临床价值持续 获得验证。国内头部企业如中国生物制药、恒瑞医药、石药集团等正加速 ...

创新药赛道，越来越火了。 曾经3000元一只的实验猴，如今身价已经飙到10万元。即便如此，依然"一猴难求"，订单甚至排到了明年中旬。 实验动物身价暴涨背后，是中国创新药的全面爆发。2025年，中国新药临床试验数量已跃居全球第二，在研管线占全球总量的30%。 这股热潮，甚至让外媒都开始集体转向。《经济学人》感叹："中国正在从仿制药大国，逐渐转变为全球创新药的中心……全球生物医药领域，以西方主 导的格局，正在发生变化。"《金融时报》则给出了一个更激进的预测：下一款"重磅炸弹"级新药，极有可能诞生在中国。 全球医药创新的重心，正在悄悄发生转移。 为什么药企巨头都在重仓中国？ 如果你这两年关注过医药行业，大概率会有一种强烈的割裂感。 一边是，在医保集采压力下，仿制药企逐渐深陷价格战泥潭，利润空间被压缩到极限，整个行业的营收都开始走下坡路。 根据中康产业研究院发布的《中国创新药蓝皮书（2025）》，2024年全国医药工业营收同比下降5.5%，超过三成企业陷入亏损，行业情绪跌至冰点。 但如果把目光投向创新药赛道，却会看到另一番景象。 同样是在2024年，中国创新药企业完成了94笔海外授权（License-out）交易，占 ...

Summary of Conference Call Records Industry Overview - The conference call primarily discusses the biopharmaceutical industry, focusing on several key companies and their projected performance for 2025 and beyond. The overall sentiment reflects a robust growth trajectory within the sector. Key Companies and Their Projections 1. WuXi AppTec (药明康德) - Expected revenue for 2025 is 454.56 billion CNY, a year-on-year increase of 15.84% - Adjusted net profit is projected to be 149.57 billion CNY, up 41.33%, with total net profit reaching 191.51 billion CNY, a 102.65% increase [2] - The company has 24 GLP-1 drug candidates, with 15 in Phase II and III clinical trials, indicating strong pipeline growth [4] 2. Kanglong Chemical (康龙化成) - Anticipates revenue between 138.72 billion CNY and 142.4 billion CNY, reflecting a growth of 13%-16% - Adjusted net profit is expected to be between 17.68 billion CNY and 18.48 billion CNY, a growth of 10%-15% [2] 3. Sunway Pharma (阳光诺和) - Projected revenue between 1.192 billion CNY and 1.37 billion CNY, a growth of 10.57%-27.15% - Expected net profit between 190 million CNY and 229 million CNY, a growth of 7.69%-29.23% [2] 4. AstraZeneca (阿斯利康) - Focused on cardiovascular, ADC, next-generation IO, and cell therapy TCE areas - Key clinical data readouts expected in 2026, which may impact market dynamics [5] 5. Gilead Sciences (吉利德) - Key projects include Cloud Native Top two ADC, expected to show promising data in TNBC treatment and potential approval in the second half of the year [8] - Anticipates significant changes in the first-line triple-negative breast cancer market due to the SG molecule [8] 6. DZD Pharma (迪哲医药) - DZD6,008 shows significant efficacy in non-small cell lung cancer (NSCLC) with an ORR of 60% and PFS exceeding 10 months [3][16] Clinical Trials and Data Readouts - Multiple companies, including Gilead, AstraZeneca, and others, are set to release important clinical trial data in 2026, which could reshape competitive dynamics in the NSCLC market [16] - AstraZeneca's ADC project 18.2 is expected to have significant clinical data readouts in 2026, with a focus on large-scale Phase III trials [7] Strategic Collaborations and Market Expansion - WuXi Biologics (药明生物) has signed a strategic cooperation memorandum with Qatar Free Zone Authority to expand into the Middle East market [4] - The conference highlighted the increasing participation of Chinese companies in the global pharmaceutical market, particularly in the dual-antibody and ADC sectors [22] Emerging Trends and Innovations - The industry is witnessing a shift towards L2.0 and ADC combinations, which are expected to become the next wave of drug development [17][18] - The importance of speed and mechanism synergy in new drug development was emphasized, indicating that early-stage projects have a higher success rate [18] Conclusion - The biopharmaceutical industry is poised for significant growth, with several companies reporting strong projections and innovative clinical developments. The upcoming clinical data releases in 2026 are anticipated to have a substantial impact on market dynamics and competitive positioning within the sector.

全年76个创新药获批，对外授权交易总额突破1300亿美元 羊城晚报全媒体记者 陈泽云 2025年，中国创新药行业迎来了真正的"黄金时刻"。当国产AI模型DeepSeek以低成本、高性能震撼世界之时，中国生物医药也上演了类似的"DeepSeek时 刻"：全年76个创新药获批，国产占比超八成；对外授权交易总额突破1300亿美元，创历史新高；港股通创新药指数全年上涨66.52%，领跑资本市场……在 出海、资本与政策三浪叠加下，中国创新药正步入全面收获期。 年度"爆款"诞生： 国产创新唱主角 2025年5月，一束光照进了I型神经纤维瘤罕见病患者群体。复星医药自主研发的1类新药芦沃美替尼片获批上市，为2岁及以上I型神经纤维瘤患儿带来治疗 希望，填补了低龄患者无药可用的临床空白。 "这些创新药在我国上市，使得我国患者可以更早获得全球生物医药创新最新成果的治疗，标志着我国生物医药领域实现了从跟跑到并跑、部分领跑的跨 越，说明我国已经成为全球生物医药创新领域的重要力量。"国家药监局药品注册管理司副司长蓝恭涛表示。 从"有药可用"到"有更多好药可用"，2025年的这场"爆款浪潮"，不仅推动了临床治疗格局的演进，也为中国创新药的 ...

Core Insights - 2026 is identified as a pivotal year for transformation and output in the global biopharmaceutical industry, with major companies revealing strategic developments at the JMP conference [1] - The industry is experiencing extreme differentiation, with ADC and GLP-1 seen as key growth engines for the next five years, while mRNA, siRNA, and RLT are transitioning from concepts to clinical norms [1][9] - The BD strategies are becoming more precise, with 2025's small-scale acquisitions starting to yield results, and the logic behind mergers and acquisitions in 2026 expected to diversify [1] Hot Track Dynamics: Dual Drivers of Technology Iteration and Indication Expansion - ADC remains a leading player in the oncology sector, with Merck advancing multiple ADC assets through collaboration with Daiichi Sankyo [12] - BeiGene views ADC as a core technology and is actively promoting drug accessibility globally [12] - Eli Lilly has completed several ADC-related transactions to enhance its capabilities in cancer treatment [12] Weight Management Market Transition - The weight management market is shifting from simple weight loss to comprehensive management of metabolic syndrome, with Eli Lilly focusing on AI-driven drug discovery and direct patient engagement [14] - Roche's acquisition of Carmot Therapeutics enhances its pipeline with new metabolic therapies [14] - Sanofi is expanding the indications for its core asset Dupixent and advancing its autoimmune pipeline [14] Key Corporate Strategic Planning: Core Track Deepening and Platform Layout - Eli Lilly's strategy focuses on obesity and AI-driven drug development, with a projected investment of up to $1 billion in collaboration with NVIDIA [15] - Pfizer aims to maximize core transaction value and apply AI across its business chain, targeting a $150 billion market in obesity by 2030 [15] - Amgen is accelerating the integration of biotechnology and AI, with a focus on rare diseases and partnerships in China [16] BD Trends: Core Logic of Track Reinforcement and Ecological Synergy - The pharmaceutical industry is seeing a concentration of mergers and acquisitions in ADC and bispecific antibodies, with major companies acquiring key assets and technology platforms [17] - Big Pharma is shifting from scale expansion to pipeline restructuring to avoid revenue cliffs due to upcoming patent expirations [18] - The focus is on mid-stage assets with immediate Phase 3 potential, which are expected to have a premium advantage over early-stage assets [18] Industry Outlook - The biopharmaceutical industry is entering an "innovation harvest period" from 2026 to 2030, with GLP-1 drugs evolving into comprehensive metabolic management platforms [19] - The market for GLP-1 receptor agonists in China is projected to reach approximately 38.3 billion yuan by 2030 [19] - The commercialization of cutting-edge therapies is approaching a "singularity," with advancements in cell and gene therapies and RNA therapies expected to overcome production and reimbursement challenges [19][20]

Core Insights - The 44th J.P. Morgan Healthcare Conference (JPM) is a significant event in the global healthcare sector, attracting over 8,000 participants, with a strong representation from biotechnology and pharmaceutical companies [1][3] - Chinese pharmaceutical companies are increasingly participating in JPM, focusing on collaboration and showcasing their innovative pipelines, particularly in the context of a booming merger and acquisition landscape in the industry [1][4] Group 1: Conference Overview - The conference is recognized as a "barometer" for development and investment in the pharmaceutical sector, featuring industry leaders and innovators discussing trends and opportunities [3] - Key areas of focus at this year's conference include biotechnology and pharmaceuticals, which account for 35% and 33% of participating companies, respectively [3] Group 2: Chinese Pharmaceutical Companies - At least 30 Chinese pharmaceutical companies are participating, with several being regular attendees, indicating a growing presence in the global market [4][5] - Notable Chinese companies presenting include BeiGene, Zai Lab, and Legend Biotech, with significant advancements in their clinical pipelines being highlighted [4] Group 3: Investment Trends - Investors are increasingly interested in the integration of AI in pharmaceuticals and how multinational companies are addressing patent cliffs and BD strategies [4][5] - The perception of Chinese pharmaceutical companies is shifting from mere asset providers to co-creators of global pharmaceutical innovation, reflecting their growing capabilities [9] Group 4: Company Innovations - Companies like China Biologic Products are undergoing significant innovation transformations, aiming for over 50% of their revenue from innovative products by 2025 [7] - Yuyuan Pharmaceutical, previously seen as a generic drug company, is transitioning to focus on nucleic acid and peptide innovative drugs, indicating a strategic shift in their business model [8]

Core Viewpoint - BeiGene has rapidly commercialized its product, Baiyueda, just eight days after receiving approval, benefiting adult patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and mantle cell lymphoma in China [1] Group 1 - BeiGene leverages its comprehensive capabilities in research, production, and commercialization to achieve swift market entry [1] - The product is now available for clinical use, indicating a quick transition from approval to patient access [1]

Core Insights - The 44th J.P. Morgan Healthcare Conference has highlighted significant industry developments, including a $1 billion investment by NVIDIA and Eli Lilly to establish a joint research lab in the San Francisco Bay Area to accelerate AI applications in the pharmaceutical sector [1] - The conference serves as a critical platform for domestic pharmaceutical companies to showcase core molecular product capabilities and advance overseas business development collaborations, indicating a return to global value validation for products [2] - The participation of over 8,000 global attendees and more than 500 listed companies underscores the strengthening global competitiveness of Chinese companies in the pharmaceutical sector [2] Group 1: Innovative Drugs - BeiGene focuses on oncology drug development and global commercialization, presenting progress on core products like CDK4 at the conference [2] - Rongchang Biologics has entered an exclusive licensing agreement with AbbVie for the novel PD-1/VEGF bispecific antibody drug RC148, granting AbbVie rights outside Greater China for development, production, and commercialization [2] - Hengrui Medicine, involved in the R&D, production, and sales of innovative and generic drugs, reported that over 50% of its revenue now comes from innovative drugs, with multiple self-developed products receiving approvals [2] Group 2: CRO/CMO - WuXi AppTec provides integrated CXO services covering the entire drug development and manufacturing process, projecting a 32.56% year-on-year growth in net profit for 2025 [3] - WuXi Biologics, specializing in biopharmaceutical CRDMO services, announced 209 new projects, bringing the total to 945, with potential milestone payments exceeding $4 billion from new research contracts [3] - Tigermed offers clinical trial CRO services and participated in the Asia-Pacific session of the conference, providing outsourcing services related to clinical trials for global pharmaceutical companies [3] Group 3: AI in Healthcare - NVIDIA and Eli Lilly's collaboration aims to build AI models to enhance new drug development, with a planned investment of $1 billion over the next five years [4] - RunDa Medical focuses on comprehensive medical testing services and is developing an automated testing interpretation system based on large models [4] - Anbiping has launched a digital pathology AI system and is exploring the registration and commercialization of AI medical devices in cervical cytology [4]