Blueprint Medicines Corporation (NASDAQ:BPMC) Q1 2023 Earnings Conference Call May 4, 2023 8:00 AM ET Company Participants Jenna Cohen - Senior Director and Head, Investor Relations Kate Haviland - Chief Executive Officer Philina Lee - Chief Commercial Officer Becker Hewes - Chief Medical Officer Mike Landsittel - Chief Financial Officer Fouad Namouni - President, Research & Development Christina Rossi - Chief Operating Officer Conference Call Participants Reni Benjamin - JMP Securities Brad Canino - Stifel ...

4. Marketable Securities | --- | --- | --- | --- | --- | --- | --- | --- | |------------------------------------------------|-------|--------------------|-------------------|-------|-----------------------|-------|--------------| | thousands): \nMarch 31, 2023 | | Amortized \nCost | Unrealized \nGain | | Unrealized \nLosses | | Fair \nValue | | Marketable securities, available-for-sale: | | | | | | | | | U.S. government agency securities | $ | 314,891 | | 28 | (2,117) | $ | 312,802 | | U.S. treasury obligat ...

Financial Data and Key Metrics Changes - For the full year 2022, total revenues were $204 million, including $111 million in net product revenues from AYVAKIT and $93 million in collaborations and license revenues, exceeding the high end of the 2022 total revenue guidance of $200 million [46][73] - Total operating expenses were $723.7 million for the full year, with Q4 operating expenses showing a quarter-over-quarter decline from Q3 as the company continues to leverage operating efficiencies [47][48] - The company expects operating expenses to grow moderately in Q1 2023, driven by preparations for the ISM launch and planned manufacturing investments [48] Business Line Data and Key Metrics Changes - AYVAKIT net product revenue doubled year-over-year in 2022, achieving $111 million, with Q4 revenues at $30.1 million, of which $26.3 million came from the U.S. [18][46] - The company anticipates AYVAKIT net product revenues of $130 million to $140 million in 2023, representing a more than 20% increase year-over-year [20][73] Market Data and Key Metrics Changes - The U.S. accounted for the majority of AYVAKIT product sales, with nearly 500 patients on AYVAKIT by the end of 2022 [8][34] - The company is preparing for the ISM launch, targeting approximately 7,500 patients with moderate to severe ISM, who are actively seeking treatment [36][40] Company Strategy and Development Direction - The company aims to expand its leadership in systemic mastocytosis and advance its clinical stage pipeline focused on best-in-class investigational therapies [13][31] - The strategy includes engaging a broader provider base for ISM patients and maintaining strong patient access to therapy [22][40] - The company is focused on achieving a sustainable financial profile while executing on a range of opportunities [31] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the growth trajectory for AYVAKIT and the anticipated launch in ISM, highlighting the strong medical need and motivated patient base [40][128] - The company is optimistic about capturing the significant ISM opportunity, supported by a strong cash position of over $1 billion [15][74] Other Important Information - The company has received EMA validation for its type 2 variation for AYVAKIT and ISM, bringing it closer to the important indication expansion and launch in Europe [69] - The FDA issued a partial clinical hold on the VELA trial due to visual adverse events, but the company is working closely with the FDA to resolve this issue [45][120] Q&A Session Summary Question: What is the overlap between current prescriber base of AYVAKIT and potential ISM patients? - The company indicated that among the top 350 prescribers, there are nearly 400 moderate to severe ISM patients who could rapidly start AYVAKIT upon approval [76][88] Question: What is the current thinking regarding vision events and the CDK2 program? - Management stated that the FDA is working cooperatively to modify the protocol and informed consent regarding the vision events observed [56][120] Question: How does the company view the early trajectory for ISM? - The company does not anticipate an initial launch bolus but expects gradual growth driven by increased disease awareness and advanced patient identification capabilities [126][128] Question: What is the current payer coverage for ISM? - The company reported strong payer coverage with virtually no access challenges for SM patients, and they do not expect a new code for ISM [153][183] Question: How is the sales force adapting to focus on allergists? - The company has expanded its field force to engage a broader provider base, including allergists, and has achieved over 40% awareness of AYVAKIT among target prescribers [149][150]

Table of Contents _____________________________ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 _____________________________ FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37359 _____________________________ BLUEPRINT MEDICINES CORPORATION (Exact Name of ...

Blueprint Medicines Corporation (NASDAQ:BPMC) Q2 2022 Earnings Conference Call August 2, 2022 8:00 AM ET Company Participants Jenna Cohen - Senior Director and Head of Investor Relations Kate Haviland - Chief Executive Officer Philina Lee - Chief Commercial Officer Becker Hewes - MD, Chief Medical Officer Christy Rossi - Chief Operating Officer Mike Landsittel - Chief Financial Officer Conference Call Participants Ernie Rodriguez - Cowen and Company Dane Leone - Raymond James Andrea Tan - Goldman Sachs Pete ...

Table of Contents _____________________________ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 _____________________________ FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37359 _____________________________ BLUEPRINT MEDICINES CORPORATION (Exact Name of Regi ...

Blueprint Medicines Corporation (NASDAQ:BPMC) Q1 2022 Earnings Conference Call May 3, 2022 8:30 AM ET Company Participants Jenna Cohen - Senior Director and Head of Investor Relations Kate Haviland - Chief Executive Officer Christy Rossi - Chief Operating Officer Philina Lee - Chief Commercial Officer Becker Hewes - MD, Chief Medical Officer Mike Landsittel - Chief Financial Officer Conference Call Participants Marc Frahm - Cowen Dane Leone - Raymond James Elizabeth - Goldman Sachs Reni Benjamin - JMP Secur ...

Table of Contents _____________________________ UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 _____________________________ FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission file number 001-37359 _____________________________ BLUEPRINT MEDICINES CORPORATION (Exact Name of Reg ...

Blueprint Medicines Corporation (NASDAQ:BPMC) Q4 2021 Earnings Conference Call February 16, 2022 8:30 AM ET Company Participants Kristin Hodous – Senior Manager-Investor Relations Jeff Albers – Chief Executive Officer Kate Haviland – Chief Operating Officer Christy Rossi – Chief Commercial Officer Becker Hewes – Chief Medical Officer Mike Landsittel – Chief Financial Officer Fouad Namouni – President-Research & Development Conference Call Participants Marc Frahm – Cowen Dane Leone – Raymond James Brad Canin ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 Form 10-K (Mark One) ☑ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to | --- | --- | --- | --- | |---------------------------------------------------------------------------|----------------------------------------- ...