Financial Performance - Total revenues increased by $4.1 million to $17.1 million in the three months ended March 31, 2024, compared to the same period in 2023, representing a 32% increase [125]. - Product revenue for the three months ended March 31, 2024, was $9.6 million, up 14% from $8.4 million in the same period of 2023 [123]. - Research and development revenue rose by 63% to $7.5 million in Q1 2024, compared to $4.6 million in Q1 2023 [123]. - The company reported a net loss of $11.5 million for the three months ended March 31, 2024, a 49% improvement from a net loss of $22.6 million in the same period of 2023 [123]. - Total costs and operating expenses decreased by 21% to $29.0 million in Q1 2024, down from $36.6 million in Q1 2023 [123]. - Selling, general, and administrative expenses decreased by 16% to $12.9 million in Q1 2024, compared to $15.4 million in Q1 2023 [130]. Strategic Initiatives - The company secured a $40.0 million strategic financing deal with Innovatus Capital Partners to strengthen its cash position ahead of key milestones [120]. - An exclusive global license agreement was entered into with Roche for the newly engineered double-stranded DNA ligase, which includes upfront and technical milestone payments [119]. - The company had $9.5 million in deferred revenue related to the $25.9 million fee received from Pfizer as of March 31, 2024 [121]. Debt and Financing - The effective interest rate for the Innovatus Loan was 14.0% as of March 31, 2024, with a principal amount outstanding of $30.0 million [136].

Exhibit 99.1 Codexis Reports First Quarter 2024 Financial Results Q1 Total Revenue Up 32% Year-over-year, Including Product Revenue Up 14%; Company Reiterates 2024 Financial Guidance First Substantial Order for dsRNA Ligase Received from Large Pharma Customer Company is in Final Stages of Enzymatically Synthesizing a Full-Length Oligonucleotide with ECO Synthesis™ Manufacturing Platform and will Provide Update at TIDES USA Meeting REDWOOD CITY, Calif., May 2, 2024 -- Codexis, Inc. (NASDAQ: CDXS), a leading ...

REDWOOD CITY, Calif., April 11, 2024 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ:CDXS), a leading enzyme engineering company, today announced the appointment of Carole Cobb, MBA, to the Company's Strategic Advisory Board (SAB). Ms. Cobb is the former Chief Operating Officer at GreenLight Biosciences, a bio-performance company developing RNA-based solutions for agriculture and pharmaceutical applications. Her deep biotechnology experience includes leadership roles across fermentation-based commercial manufactu ...

Codexis, Inc. (NASDAQ:CDXS) Q4 2023 Earnings Conference Call February 28, 2024 4:30 PM ET Company Participants Carrie McKim - Director of IR Stephen Dilly - President and CEO Kevin Norrett - COO Sri Ryali - CFO Stefan Lutz - SVP of Research Conference Call Participants Brandon Couillard - Jefferies Evan Stampler - Stifel Steven Mah - TD Cowen Jacob Johnson - Stephens Matthew Hewitt - Craig-Hallum Capital Group Operator Welcome to the Codexis Fourth Quarter and Full Year 2023 Earnings Conference Call. [Opera ...

Codexis (CDXS) came out with quarterly earnings of $0.02 per share, beating the Zacks Consensus Estimate of a loss of $0.16 per share. This compares to loss of $0.19 per share a year ago. These figures are adjusted for non-recurring items.This quarterly report represents an earnings surprise of 112.50%. A quarter ago, it was expected that this producer of custom industrial enzymes would post a loss of $0.32 per share when it actually produced a loss of $0.26, delivering a surprise of 18.75%.Over the last fo ...

[CEO Statement & Strategic Outlook](index=1&type=section&id=CEO%20Statement%20%26%20Strategic%20Outlook) Codexis focuses on ECO Synthesis™ for double-digit Pharmaceutical Manufacturing growth, monetizing non-core assets, and securing non-dilutive financing - The company's core strategy for 2024 is to focus on the ECO Synthesis™ manufacturing platform and return the Pharmaceutical Manufacturing business to **double-digit growth**[1](index=1&type=chunk) - Codexis is monetizing non-core assets through strategic partnerships, including asset purchases with Nestlé Health Science (CDX-7108) and Roche (dsDNA ligase), and an out-licensing deal with Aldevron (Codex® HiCap RNA Polymerase)[1](index=1&type=chunk) - A non-dilutive financing agreement with Innovatus has been secured to strengthen the company's financial position, extend its cash runway, and fund the development of the ECO Synthesis™ platform[1](index=1&type=chunk) [Fourth Quarter and Recent Business Highlights](index=1&type=section&id=Fourth%20Quarter%20and%20Recent%20Business%20Highlights) Codexis advanced its ECO Synthesis™ platform to gram-scale, formed a Strategic Advisory Board, and secured significant financing and licensing deals - Achieved a key technical milestone in December 2023 by demonstrating **gram-scale synthesis** with the ECO Synthesis™ platform, enabling purity profile assessments and discussions with early access customers[10](index=10&type=chunk) - Formed a Strategic Advisory Board including Dr. John Maraganore (former Alnylam CEO), Dr. Masad Damha, and Dr. Jim Lalonde to guide the development of the ECO Synthesis™ platform[6](index=6&type=chunk)[8](index=8&type=chunk) - Entered into a purchase agreement with Nestlé Health Science for CDX-7108, receiving a **$5 million upfront payment** and potential for up to **$45 million** in total milestones plus royalties[12](index=12&type=chunk) - Secured up to **$40 million** in a non-dilutive loan facility from Innovatus Capital Partners to reinforce its cash position and accelerate ECO Synthesis™ platform development[13](index=13&type=chunk) - Signed an exclusive global license agreement with Roche for a newly engineered dsDNA ligase and an exclusive license with Aldevron for the Codex® HiCap RNA Polymerase[11](index=11&type=chunk)[14](index=14&type=chunk) [Upcoming Milestones](index=3&type=section&id=Upcoming%20Milestones) Codexis plans a technical update on ECO Synthesis™ at TIDES USA, initiates early access customer testing in H2 2024, and expects ecoRNA™ ligase availability - A technical update on the ECO Synthesis™ platform is planned for the TIDES USA annual meeting in May 2024, showcasing the linear synthesis of a full-length oligonucleotide strand[15](index=15&type=chunk) - Early access customer testing for the ECO Synthesis™ platform is on track to begin in **H2 2024**, with potential for initial commercial licensing in **2025** and a full launch in **2026**[16](index=16&type=chunk)[17](index=17&type=chunk) - The newly engineered ecoRNA™ ligase program is expected to be widely available to customers in **H2 2024**, aiming to improve traditional phosphoramidite chemistry[18](index=18&type=chunk) [Financial Performance](index=4&type=section&id=Financial%20Performance) This section details Codexis's financial results for fiscal year 2023 and Q4 2023, along with its financial guidance for 2024 [Fiscal Year 2023 Financial Highlights](index=4&type=section&id=Fiscal%20Year%202023%20Financial%20Highlights) FY2023 saw total revenues decline to $70.1 million due to PAXLOVID™ sales, a net loss of $76.2 million, and improved product gross margin to 70% Fiscal Year 2023 Financial Highlights | Metric | FY 2023 | FY 2022 | Change | | :--- | :--- | :--- | :--- | | **Total Revenues** | **$70.1M** | **$138.6M** | **-49.4%** | | Total Revenues (ex-PAXLOVID™) | $62.0M | $63.2M | -2% | | **Product Revenues** | **$42.9M** | **$116.7M** | **-63.2%** | | Product Revenues (ex-PAXLOVID™) | $34.8M | $41.3M | -16% | | R&D Revenues | $27.2M | $21.9M | +24.2% | | **Product Gross Margin** | **70%** | **67%** | **+3 p.p.** | | Product Gross Margin (ex-PAXLOVID™) | 63% | 52% | +11 p.p. | | R&D Expenses | $58.9M | $80.1M | -26.5% | | SG&A Expenses | $53.3M | $52.2M | +2.1% | | **Net Loss** | **($76.2M)** | **($33.6M)** | **+126.8%** | | Net Loss per Share | ($1.12) | ($0.51) | +119.6% | - As of December 31, 2023, the company had pro forma cash and cash equivalents of **$70.1 million**, which includes a **$5.0 million** upfront payment from Nestlé received in January 2024[26](index=26&type=chunk) [Fourth Quarter 2023 Financial Highlights](index=4&type=section&id=Fourth%20Quarter%202023%20Financial%20Highlights) Q4 2023 total revenues were $26.6 million, with 42% growth excluding PAXLOVID™, product gross margin improved to 84%, and net loss narrowed to $7.2 million Fourth Quarter 2023 Financial Highlights | Metric | Q4 2023 | Q4 2022 | Change | | :--- | :--- | :--- | :--- | | **Total Revenues** | **$26.6M** | **$30.4M** | **-12.5%** | | Total Revenues (ex-PAXLOVID™) | $18.4M | $13.0M | +42% | | **Product Revenues** | **$18.1M** | **$23.3M** | **-22.3%** | | Product Revenues (ex-PAXLOVID™) | $9.9M | $5.9M | +69% | | R&D Revenues | $8.5M | $7.1M | +19.7% | | **Product Gross Margin** | **84%** | **64%** | **+20 p.p.** | | Product Gross Margin (ex-PAXLOVID™) | 71% | 44% | +27 p.p. | | **Net Loss** | **($7.2M)** | **($12.6M)** | **-42.9%** | | Net Loss per Share | ($0.10) | ($0.19) | -47.4% | - R&D expenses decreased to **$11.2 million** from **$19.7 million** year-over-year, driven by lower headcount and reduced outside services costs[33](index=33&type=chunk) [2024 Financial Guidance](index=6&type=section&id=2024%20Financial%20Guidance) Codexis projects 2024 product revenues (ex-PAXLOVID™) between $38M-$42M, R&D revenues $18M-$22M, and expects cash flow positivity by late 2026 2024 Financial Guidance | Guidance Metric | 2024 Range | | :--- | :--- | | Product Revenues (ex-PAXLOVID™) | $38M - $42M | | R&D Revenues | $18M - $22M | | Gross Margin on Product Revenue (ex-PAXLOVID™) | 58% - 63% | - The company anticipates product revenue growth of at least **10%** versus 2023, excluding enzyme sales related to PAXLOVID™[4](index=4&type=chunk) - Codexis expects its existing cash and cash equivalents will fund planned operations through to expected positive cash flow around the **end of 2026**[44](index=44&type=chunk) [Financial Statements](index=10&type=section&id=Financial%20Statements) This section presents Codexis's consolidated statements of operations and balance sheets for the reported periods [Consolidated Statements of Operations](index=10&type=section&id=CODEXIS%2C%20INC.%20AND%20SUBSIDIARIES%20CONSOLIDATED%20STATEMENTS%20OF%20OPERATIONS) The consolidated statements of operations show a net loss of $76.2 million for FY2023 and a narrowed net loss of $7.2 million for Q4 2023 Consolidated Statements of Operations | (In thousands, except per share data) | Three Months Ended Dec 31, 2023 | Three Months Ended Dec 31, 2022 | Year Ended Dec 31, 2023 | Year Ended Dec 31, 2022 | | :--- | :--- | :--- | :--- | :--- | | **Total revenues** | **$26,561** | **$30,375** | **$70,143** | **$138,590** | | Total costs and operating expenses | $26,279 | $43,626 | $138,212 | $173,471 | | Loss from operations | $282 | ($13,251) | ($68,069) | ($34,881) | | **Net loss** | **($7,192)** | **($12,605)** | **($76,240)** | **($33,592)** | | Net loss per share, basic and diluted | ($0.10) | ($0.19) | ($1.12) | ($0.51) | [Consolidated Balance Sheets](index=11&type=section&id=CODEXIS%2C%20INC.%20AND%20SUBSIDIARIES%20CONSOLIDATED%20BALANCE%20SHEETS) The consolidated balance sheet shows total assets of $136.6 million and total liabilities of $49.9 million as of December 31, 2023 Consolidated Balance Sheets | (In thousands) | December 31, 2023 | December 31, 2022 | | :--- | :--- | :--- | | **Assets** | | | | Cash and cash equivalents | $65,116 | $113,984 | | Total current assets | $93,466 | $162,894 | | **Total assets** | **$136,561** | **$250,393** | | **Liabilities and Stockholders' Equity** | | | | Total current liabilities | $35,830 | $49,066 | | **Total liabilities** | **$49,946** | **$105,596** | | **Total stockholders' equity** | **$86,615** | **$144,797** | | **Total liabilities and stockholders' equity** | **$136,561** | **$250,393** | [Other Information](index=6&type=section&id=Other%20Information) This section provides details on the conference call, company overview, and forward-looking statement disclosures [Conference Call and Webcast](index=6&type=section&id=Conference%20Call%20and%20Webcast) Codexis held a conference call and webcast on February 28, 2024, to discuss financial results, with replay available online - A conference call and webcast were held on February 28, 2024, at 4:30 p.m. ET. A replay is available on the investor section of the company's website for 90 days[45](index=45&type=chunk)[46](index=46&type=chunk) [About Codexis](index=7&type=section&id=About%20Codexis) Codexis is an enzyme engineering company leveraging its CodeEvolver® platform for pharmaceutical manufacturing and nucleic acid synthesis, focusing on ECO Synthesis™ for RNAi therapeutics - Codexis is a leading enzyme engineering company using its CodeEvolver® platform to develop enzymes for pharmaceutical manufacturing and nucleic acid synthesis, with a current focus on its ECO Synthesis™ platform for RNAi therapeutics[47](index=47&type=chunk) [Forward-Looking Statements](index=7&type=section&id=Forward-Looking%20Statements) This report includes forward-looking statements on milestones, ECO Synthesis™ timeline, 2024 guidance, and cash flow, subject to inherent risks and uncertainties - The report contains forward-looking statements concerning milestones, the ECO Synthesis™ platform timeline, 2024 financial guidance, and future cash flow. These are subject to risks and uncertainties detailed in SEC filings[48](index=48&type=chunk)

In July 2022, we announced that we and Pfizer Inc. ("Pfizer") had entered into an agreement to supply Pfizer with CDX-616, a proprietary high-performance enzyme used to manufacture a critical intermediate for nirmatrelvir, an active pharmaceutical ingredient in PAXLOVID™, Pfizer's antiviral therapeutic, which is now approved in the United States for the treatment of mild-to-moderate COVID19 in people at high risk of progression to severe illness, and also authorized or approved by other regulatory authoriti ...

REDWOOD CITY, Calif., Feb. 26, 2024 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ:CDXS), a leading enzyme engineering company, today announced it has entered into an agreement with Roche for an exclusive, global license for the Company's newly engineered double-stranded DNA (dsDNA) ligase for next-generation sequencing (NGS) library preparation and the Company's EvoT4™ DNA ligase. Under the terms of the deal, Codexis will receive upfront and technical milestone payments. This deal supersedes the prior exclusive ...

REDWOOD CITY, Calif., Feb. 26, 2024 (GLOBE NEWSWIRE) -- Codexis, Inc. (NASDAQ:CDXS), a leading enzyme engineering company, today announced the Company will attend the TD Cowen 44th Annual Health Care Conference, being held March 4-6, 2024, in Boston, Massachusetts. Management will participate in a fireside chat on Monday, March 4, 2024, at 2:50 pm ET. A live webcast of the event will be available here and in the Investor Relations section of the Company's website, http://ir.codexis.com. A replay will be arc ...

Wix.com Ltd (WIX) is slated to report fourth-quarter 2023 results on Feb 21.The company expects fourth-quarter revenues to be between $400 million and $405 million, suggesting 13-14% growth from the prior-year figure. The Zacks Consensus Estimate is pegged at $402.6 million, indicating an increase of 13.4% from a year ago.The Zacks Consensus Estimate for earnings is pegged at 98 cents per share. The company reported earnings of 61 cents in the year-ago quarter.WIX’s earnings beat the Zacks Consensus Estimat ...