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Castle Biosciences (NasdaqGM:CSTL) Q3 2025 Earnings Call November 03, 2025 04:30 PM ET Speaker2Good afternoon and welcome to Castle Biosciences' third quarter 2025 conference call. As a reminder, today's call is being recorded. We will begin today's call with opening remarks and introductions, followed by a question-and-answer session. I would like to turn the call over to Camilla Zuckero, Vice President, Investor Relations and Corporate Affairs. Please go ahead.Speaker0Thank you, Operator. Good afternoon, ...

Empowering people, informing care decisions November 2025 ©2025 Castle Biosciences 1 Disclaimers Forward-Looking Statements This presentation contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the "safe harbor" created by those sections. These forward-looking statements include, but are not limited to, statements concerning: our positioning for continued grow ...

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from _________ to _________ Commission File Number: 001-38984 CASTLE BIOSCIENCES, INC. (Exact name of registrant as specified in its charter) ...

Exhibit 99.1 Announced launch of AdvanceAD-Tx™, the Company's test designed to guide systemic treatment decision making in patients ages 12 and older with moderate-to-severe atopic dermatitis (AD) Q3 2025 total test reports for our core revenue drivers (DecisionDx -Melanoma, TissueCypher ) increased 36% over Q3 2024 ® ® Castle Biosciences Reports Third Quarter 2025 Results Delivered Q3 2025 revenue of $83 million Q3 2025 non-dermatologic revenue increased by 67% over Q3 2024 Conference call and webcast toda ...

Delivered Q3 2025 revenue of $83 million Q3 2025 non-dermatologic revenue increased by 67% over Q3 2024 Q3 2025 total test reports for our core revenue drivers (DecisionDx®-Melanoma, TissueCypher®) increased 36% over Q3 2024 Raising full-year 2025 revenue guidance to $327-335 million from $310-320 million Announced launch of AdvanceAD-Tx™, the Company’s test designed to guide systemic treatment decision making in patients ages 12 and older with moderate-to-severe atopic dermatitis (AD) Conference call and w ...

Validation study data show AdvanceAD-Tx can identify patients with AD who have a ‘JAKi responder profile’ and a superior response to JAKi therapies compared to Th2-targeted therapiesFRIENDSWOOD, Texas, Nov. 03, 2025 (GLOBE NEWSWIRE) -- Castle Biosciences, Inc. (Nasdaq: CSTL), a company improving health through innovative tests that guide patient care, today announced the launch of AdvanceAD-Tx™, a gene expression profile (GEP) test designed to guide systemic treatment decision making in patients ages 12 and ...

Castle Biosciences (NASDAQ:CSTL – Get Free Report) will likely be posting its Q3 2025 results after the market closes on Monday, November 3rd. Analysts expect Castle Biosciences to post earnings of ($0.35) per share and revenue of $71.0620 million for the quarter. Castle Biosciences has set its FY 2025 guidance at EPS.Individuals can find conference call details on the company’s upcoming Q3 2025 earningreport page for the latest details on the call scheduled for Monday, November 3, 2025 at 4:30 PM ET. Get ...

Core Viewpoint - Castle Biosciences, Inc. (CSTL) is expected to report a year-over-year decline in earnings and revenues for the quarter ended September 2025, with a consensus outlook indicating a quarterly loss of $0.34 per share and revenues of $71.3 million, down 16.9% from the previous year [1][3]. Earnings Expectations - The upcoming earnings report is anticipated to be released on November 3, and the stock may experience price movement based on whether the actual results exceed or fall short of expectations [2]. - The consensus EPS estimate has remained unchanged over the last 30 days, indicating stability in analyst expectations [4]. Earnings Surprise Prediction - The Most Accurate Estimate for Castle Biosciences aligns with the Zacks Consensus Estimate, resulting in an Earnings ESP of 0%, suggesting no recent differing analyst views [12]. - Despite the Earnings ESP of 0%, the stock holds a Zacks Rank of 1 (Strong Buy), which typically indicates a higher likelihood of an earnings beat [12]. Historical Performance - In the last reported quarter, Castle Biosciences was expected to post a loss of $0.51 per share but instead reported earnings of $0.15, resulting in a surprise of +129.41% [14]. - Over the past four quarters, the company has beaten consensus EPS estimates three times [15]. Industry Context - In the broader Zacks Medical - Biomedical and Genetics industry, Biogen Inc. (BIIB) is expected to report earnings of $3.89 per share for the same quarter, reflecting a year-over-year change of -4.7% and revenues of $2.34 billion, down 5.1% from the previous year [19][20].

Core Insights - Castle Biosciences announced new data showing that its TissueCypher® Barrett's Esophagus test provides risk insights beyond pathology, aiding in clinical management and supporting earlier interventions for patients at higher risk of progression to esophageal cancer [1][2] Group 1: Research Findings - The TissueCypher test identifies patients at higher risk of progression to esophageal cancer, which may be missed when relying solely on pathology [2] - New data from case studies indicate that TissueCypher returned high-risk results with five-year probabilities of progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) of 34% and 62%, respectively, which are higher than the published rates of progression from HGD to EAC (33% over five years) [6] - In a study involving patients with non-dysplastic Barrett's esophagus (NDBE), TissueCypher identified high-risk patients with five-year probabilities of progression to HGD/EAC of 43% and 45%, leading to earlier interventions [6][13] Group 2: Clinical Impact - The TissueCypher test influenced clinical management in 93% of cases in a rural Texas study, allowing for timely interventions for higher-risk patients while reducing unnecessary procedures for lower-risk patients [13] - The test's ability to provide individualized risk stratification supports more personalized decisions around surveillance and intervention, potentially reducing the risk of progression to esophageal cancer [2][6] Group 3: Recognition and Presentation - The research findings will be presented at the American College of Gastroenterology (ACG) 2025 Annual Scientific Meeting, with one abstract selected for a Presidential Poster Award, highlighting the quality and significance of the research [2][4] - A total of more than 6,400 scientific abstracts will be presented at the ACG 2025, with only a small percentage receiving the Presidential Poster Award [2] Group 4: About TissueCypher - The TissueCypher Barrett's Esophagus test is designed to predict future development of HGD and/or EAC in patients with Barrett's esophagus, and has been supported by 14 peer-reviewed publications [8] - The test received Advanced Diagnostic Laboratory Test (ADLT) status from the Centers for Medicare & Medicaid Services (CMS) in March 2022, indicating its clinical significance [8] Group 5: Company Overview - Castle Biosciences is a leading diagnostics company focused on improving health through innovative tests that guide patient care, with a portfolio that includes tests for skin cancers, Barrett's esophagus, and uveal melanoma [9][10] - The company is actively engaged in research and development for tests addressing high clinical needs, including a test for moderate-to-severe atopic dermatitis [10]