Summary of Conference Call Company Overview - The conference was held at the Piper Sandler Healthcare Conference featuring Doretta Mistras (CFO) and Philippe Martin (Chief R&D Officer) of the company [1][2] Capital Deployment Strategy - The company maintains a balanced capital allocation philosophy, aiming for a 50/50 split between capital deployment and capital return over a three to five-year period [2] - In the current year, the focus has been on capital returns, particularly share buybacks, due to operational circumstances and stock price considerations [2] - The company is actively pursuing innovative, branded, patent-protected assets to enhance near-term revenue and EBITDA growth, particularly in the US [3] R&D Focus - The current strategy emphasizes commercial-stage assets, with a focus on late-stage products like Cenerimod and Selatogrel [5] - Cenerimod is undergoing two large Phase III studies for systemic lupus erythematosus (SLE), with OPUS-2 fully enrolled and OPUS-1 expected to follow shortly [7] - The drug is positioned to be used alongside standard treatments without adding safety concerns, targeting a significant unmet need in SLE and lupus nephritis [8][15] Clinical Trials and Market Positioning - The Phase III trials for Cenerimod are designed to account for previous learnings, particularly focusing on patients with high interferon I levels, which showed the greatest treatment effect [9] - The company is optimistic about the potential of Cenerimod in lupus nephritis, having received positive feedback from regulatory bodies [11][12] - Selatogrel's Phase III global program for acute myocardial infarction is progressing well, with nearly 1,000 patients enrolled per month and full enrollment expected by the end of the year [16] Fast-Acting Meloxicam Product - The company is preparing for a pre-NDA meeting with the FDA to discuss filing and potential for accelerated review [20] - The fast-acting meloxicam product targets over 80 million acute pain cases annually, with a focus on outpatient and ambulatory surgical centers [22] - The product aims to provide a non-opioid alternative in a market where over 50% of acute pain cases still rely on opioids [22] Market Differentiation and Pricing Strategy - The company is exploring pricing strategies and market access for the fast-acting meloxicam, aiming for a balance between value proposition and broad patient access [24] - The product is expected to have a minimum of three years of exclusivity through the 505(b)(2) pathway, with ongoing efforts to extend this exclusivity [28] Presbyopia Opportunity - The company sees a significant market opportunity in presbyopia, with over 90% of adults over 45 affected, and aims to differentiate its product through a unique mechanism of action that avoids common side effects associated with other treatments [30][32] Enterprise-Wide Strategic Review - An enterprise-wide strategic review is underway to enhance long-term sustainable revenue and EBITDA growth, focusing on various operational aspects including R&D, manufacturing, and commercial infrastructure [34] Conclusion - The company is strategically positioned to leverage its R&D pipeline and capital deployment strategy to drive growth and address unmet medical needs across various therapeutic areas [34]

Core Insights - During market turbulence, investors often seek dividend-yielding stocks, which typically have high free cash flows and offer substantial dividends [1] Group 1: CVS Health Corp (NYSE:CVS) - CVS Health has a dividend yield of 3.31% [7] - Truist Securities analyst David Macdonald maintained a Buy rating and raised the price target from $92 to $95 on October 30, 2025, with an accuracy rate of 69% [7] - Morgan Stanley analyst Erin Wright maintained an Overweight rating and increased the price target from $82 to $89 on October 14, 2025, with an accuracy rate of 75% [7] - Recent news includes the appointment of David Joyner as Chair of the board of directors on November 20 [7] Group 2: Viatris Inc (NASDAQ:VTRS) - Viatris has a dividend yield of 4.49% [7] - Truist Securities analyst Srikripa Devarakonda initiated coverage with a Buy rating and a price target of $15 on October 15, 2025, with an accuracy rate of 67% [7] - Goldman Sachs analyst Matt Dellatorre initiated coverage with a Neutral rating and a price target of $10 on June 6, 2025, with an accuracy rate of 69% [7] - Recent news highlights Viatris posting upbeat earnings for the third quarter on November 6 [7] Group 3: Bristol-Myers Squibb Co (NYSE:BMY) - Bristol-Myers Squibb has a dividend yield of 5.04% [7] - Citigroup analyst Andrew Baum maintained a Neutral rating and reduced the price target from $48 to $45 on November 17, 2025, with an accuracy rate of 72% [7] - Wells Fargo analyst Mohit Bansal maintained an Equal-Weight rating and cut the price target from $62 to $53 on April 28, 2025, with an accuracy rate of 71% [7] - Recent news includes the European Commission's approval for expanding the use of CAR T Cell Therapy Breyanzi for Relapsed or Refractory Mantle Cell Lymphoma on November 24 [7]

Summary of Viatris 2025 Conference Call Company Overview - **Company**: Viatris (NasdaqGS: VTRS) - **Event**: Jeffries London Healthcare Conference - **Date**: November 18, 2025 Key Points Industry and Company Progress - **2025 Overview**: The year has been characterized by both challenges and significant progress, including strong commercial execution across multiple geographies [2][4] - **Pipeline Success**: Five out of six phase three studies were positive, with launches expected in 2026 and beyond [2][4] - **Capital Return**: Approximately $500 million in share buybacks completed, with over $1 billion anticipated in total capital return to shareholders for 2025 [3][4] Financial Strategy - **Cost Review**: An enterprise-wide strategic review is underway to identify cost savings and ensure the right organizational structure post-merger [4][6] - **Cost Savings**: Expected meaningful savings from the review, with a majority falling to the bottom line and a portion reinvested for growth [10][7] Regulatory and Operational Updates - **FDA Inspection**: Product reinspection by the FDA is anticipated in the first half of 2026, with over 90% of remediation completed [11][12] - **Manufacturing Strategy**: Efforts are being made to qualify other plants and find third-party vendors to ensure product supply regardless of inspection timing [12] Business Development and Capital Allocation - **Balanced Approach**: The capital allocation strategy emphasizes a balance between dividends, share buybacks, and investment in growth assets [13][14] - **Acquisition Focus**: Interest in in-market, high-margin revenue assets, with recent acquisitions in Japan to enhance the portfolio [14][16] Pipeline Highlights - **Upcoming Products**: Excitement around fast-acting meloxicam and Xulane low-dose patch, with launches expected in 2026 [18][19] - **Sotagliflozin**: Currently being registered globally, with strong enthusiasm noted for its potential [19][20] - **Market Opportunity**: The acute pain market in the U.S. is approximately 80 million cases, with a significant portion currently treated with opioids [26][27] Competitive Landscape - **Differentiation**: Fast-acting meloxicam is positioned as a unique offering with a significant opioid-sparing effect, differentiating it from competitors [20][26] - **Presbyopia Market**: Viatris is optimistic about its asset for Presbyopia, highlighting a favorable safety profile compared to competitors [34][35] Revenue Projections - **New Product Revenue**: Anticipated new product revenue for 2026 is projected between $450 million and $550 million, driven by recent approvals and upcoming launches [37][40] - **Overall Growth**: 2026 is expected to be a strong year for revenue growth, supported by both new product launches and a stable base business [42] Conclusion - **Outlook**: Viatris is preparing for a period of sustained growth, with a focus on leveraging its diverse portfolio and geographic presence to capitalize on upcoming opportunities in 2026 and beyond [4][42]

Core Insights - Investors are increasingly turning to dividend-yielding stocks during market turbulence, favoring companies with high free cash flows that offer substantial dividends [1] Company Summaries Pfizer Inc (NYSE:PFE) - Dividend Yield: 6.67% - Morgan Stanley analyst Terence Flynn maintained an Equal-Weight rating and reduced the price target from $33 to $32 as of October 10, 2025, with an accuracy rate of 67% [7] - B of A Securities analyst Tim Anderson kept a Neutral rating and increased the price target from $28 to $30 on October 3, 2025, with an accuracy rate of 66% [7] - Recent News: Pfizer completed the acquisition of Metsera, Inc. on November 13 [7] DENTSPLY SIRONA Inc (NASDAQ:XRAY) - Dividend Yield: 5.84% - William Blair analyst Brandon Vazquez downgraded the stock from Outperform to Market Perform on November 7, 2025, with an accuracy rate of 68% [7] - UBS analyst Kevin Caliendo maintained a Buy rating but cut the price target from $24 to $23 on October 28, 2025, with an accuracy rate of 67% [7] - Recent News: Dentsply Sirona reported weaker-than-expected third-quarter earnings and lowered guidance on November 6 [7] Viatris Inc (NASDAQ:VTRS) - Dividend Yield: 4.40% - Goldman Sachs analyst Matt Dellatorre initiated coverage with a Neutral rating and a price target of $10 on June 6, 2025, with an accuracy rate of 68% [7] - Piper Sandler analyst David Amsellem reiterated a Neutral rating and reduced the price target from $14 to $10 on March 5, 2025, with an accuracy rate of 78% [7] - Recent News: Viatris reported better-than-expected quarterly earnings on November 6 [7]

Core Insights - Viatris Inc. (NASDAQ: VTRS) has shown strong performance, with a 10.13% increase in stock price, closing at $11.20 after reaffirming growth targets at the UBS Healthcare Conference [1] - The company aims to return $1 billion to shareholders this year through dividends and share repurchases [1] - Year-to-date, Viatris has returned over $920 million to shareholders, including $500 million in share repurchases [2] Financial Performance - For full-year 2025, Viatris raised its revenue growth guidance to a range of $13.9 billion to $14.3 billion, up from the previous range of $13.5 billion to $14 billion [3] - Adjusted EBITDA guidance was also upgraded to a range of $4 billion to $4.2 billion, compared to the earlier range of $3.89 billion to $4.19 billion [3] - In Q3, Viatris reported a net loss of $128.2 million, a decline from a net income of $94.8 million in the same period last year, with revenues remaining flat at $3.7 billion [4]

Core Insights - The company reported third quarter earnings and is experiencing positive momentum in its business operations [1] - The company is on track to achieve 2% to 3% operational revenue growth, excluding Indore, with expectations for continued positive momentum into 2026 [2] - The company has successfully delivered 5 out of 6 positive pipeline readouts in the first half of the year, indicating strong execution against strategic priorities [2] - The company is committed to capital allocation priorities, planning to return over $1 billion to shareholders, which includes $500 million in share repurchases this year [3]

Core Insights - Theravance Biopharma (TBPH) reported third-quarter 2025 adjusted earnings of 4 cents per share, exceeding the Zacks Consensus Estimate of a loss of 3 cents, and improved from an adjusted loss of 6 cents per share in the same quarter last year [1][6] - Total revenues for the third quarter reached $20 million, aligning with the Zacks Consensus Estimate, and reflecting a 19% year-over-year increase driven by collaboration revenues from partner Viatris (VTRS) [1][6] Financial Performance - The revenue for the quarter was solely derived from Viatris' collaboration revenues related to Yupelri (revefenacin) sales [3] - U.S. sales of Yupelri increased by 15% year over year, contributing to the positive financial results [6] - Viatris recorded $71.4 million in U.S. net sales of Yupelri for the third quarter, marking a 15% increase from the previous year [7] Expense Management - Research and development expenses (excluding share-based compensation) totaled $7 million, a decrease of approximately 14.6% from the year-ago quarter [7] - Selling, general and administrative expenses (excluding share-based compensation) rose around 13.8% year over year to $14.8 million [7] Cash Position - As of September 30, 2025, Theravance had cash, cash equivalents, and marketable securities amounting to $332.7 million, down from $338.8 million as of June 30, 2025 [8] Financial Guidance - Theravance reaffirmed its financial guidance for 2025, expecting adjusted R&D expenses (excluding share-based compensation) in the range of $32-$38 million and adjusted SG&A expenses between $50 million and $60 million [9] - The company anticipates share-based compensation expenses of $18-$20 million in 2025 [9] Pipeline Developments - Theravance is developing ampreloxetine, a norepinephrine reuptake inhibitor for treating symptomatic neurogenic orthostatic hypotension (nOH) in patients with multiple system atrophy (MSA) [11] - The pivotal phase III CYPRESS study for ampreloxetine has completed enrollment, with top-line data expected in the first quarter of 2026 [11] - An expedited new drug application (NDA) filing for ampreloxetine is planned if the study data are positive, with a request for priority review from the FDA [12]

Summary of Viatris Conference Call Company Overview - **Company**: Viatris (NasdaqGS: VTRS) - **Event**: UBS Healthcare Conference - **Date**: November 11, 2025 Key Updates and Financial Performance - Viatris reported a positive momentum in business with an expected operational revenue growth of **2-3%** for 2025, excluding Indor [4][80] - The company is on track to return over **$1 billion** to shareholders, including **$500 million** in share repurchases for the year [4][80] New Product Launches - Anticipated new product revenue is projected to be in the range of **$450 million to $550 million** annually, driven by existing products and upcoming launches [6][4] - Key products contributing to this revenue include: - **Iron sucrose** - **Glucagon** - **Paclitaxel** - Upcoming launches: **Liraglutide**, **Effexor GAD**, **Sotagliflozin** [6][4] Geographic Performance - **North America**: - Experienced competition in generic products, particularly **XULANE LO** [17][22] - Decline primarily attributed to the impact of Indor [19][22] - Strong double-digit growth noted in products like **Breyna** and **Uptravi** [22][22] - **Emerging Markets**: - Strong growth driven by established brand business, particularly in **Turkey**, **Mexico**, and **emerging Asia** [23][23] - Stabilization of lower-margin ARV products has supported growth in the generics business [23][23] - **Japan**: - Facing normal price regulations but focusing on adding innovative assets to stabilize and grow the business [26][26] - Recent acquisition of **Pitolisant** and **Spidea** expected to enhance the portfolio [26][26] - **China**: - Achieved **9% operational growth** driven by a diversified commercial model and strong brand demand [28][28] - Over **10,000 customers** across various channels, with expectations for low to mid-single-digit growth over time [31][31] Pipeline and Future Products - Excitement around **fast-acting meloxicam** as a non-opioid alternative for acute pain management, targeting a launch in the second half of **2026** [34][41] - Anticipated FDA filings for several products, including **Effexor GAD** and **Salatogrel**, with enrollment for Salatogrel on track to complete by the end of **2026** [51][52] Indor Remediation and Strategic Review - Progress on remediation efforts for Indor, with operational readiness for reinspection expected in **2026** [54][54] - An enterprise-wide strategic review initiated to ensure sustainable growth, with details expected in **Q1 2026** [60][60] Capital Allocation Strategy - Viatris maintains a balanced capital allocation strategy, focusing on business development and capital return, with a **50/25/25** framework [71][71] - The company is looking for opportunities to invest in durable, higher-margin innovative assets, particularly in the U.S. market [73][73] Conclusion - Viatris is optimistic about its position going into **2026**, with a focus on executing its strategic priorities, enhancing its product pipeline, and addressing challenges in various markets [80][80]

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Acquisitions and Strategic Focus - Viatris acquired Aculys Pharma for $35.0 million, gaining rights to develop pitolisant and Spydia® in Japan, expanding its innovative product portfolio [233] - The acquisition of Idorsia Products included an upfront payment of $350 million and potential milestone payments totaling up to $2.4 billion [243] - Viatris' strategic focus includes expanding its portfolio through acquisitions and innovative product development [220] - The company is continuously evaluating potential acquisitions and divestitures as part of its future growth strategy, which may impact future liquidity [328] Financial Performance - Total revenues for the three months ended September 30, 2025, were $3.76 billion, an increase of $8.7 million compared to $3.75 billion in the prior year period [249] - Net sales for the same period were $3.75 billion, reflecting an increase of $9.5 million, or essentially flat, compared to the prior year [253] - The company reported a net loss of $128.2 million for the three months ended September 30, 2025, compared to net earnings of $94.8 million in the prior year, representing a decrease of $223 million [249] - For the nine months ended September 30, 2025, total revenues were $10.60 billion, a decrease of $614.9 million compared to $11.21 billion in the prior year [249] - Net sales for the nine months ended September 30, 2025 were $10.56 billion, down $617.7 million or 6% compared to the previous year [278] - The company recorded a net loss of $3,174.8 million for the nine months ended September 30, 2025, compared to a net loss of $117.7 million for the same period in 2024 [312] Gross Profit and Margins - The gross profit for the three months ended September 30, 2025, was $1.37 billion, down $87.7 million from $1.46 billion in the prior year [249] - Gross profit for the nine months ended September 30, 2025 was $3.87 billion, with gross margins at 36%, down from $4.41 billion and 39% in the prior year [289] - Adjusted gross profit for the three months ended September 30, 2025 was $2.10 billion, with adjusted gross margins at 56%, compared to $2.19 billion and 58% in the prior year [264] - Adjusted gross profit for the same period was $5,952.4 million, resulting in an adjusted gross margin of 56%, down from 58% in 2024 [290] Expenses - R&D expenses increased by $52.0 million to $250.4 million for the three months ended September 30, 2025, primarily due to higher costs for development programs [265] - SG&A expenses decreased by $116.8 million to $886.6 million for the current quarter, mainly due to lower acquisition-related costs [266] - Selling, General and Administrative (SG&A) expenses decreased to $2.76 billion in 2025 from $3.06 billion in 2024, a reduction of $294.5 million attributed to divestitures and lower acquisition-related costs [293] - Interest expense decreased to $351.7 million in 2025 from $429.8 million in 2024, a reduction of $78.1 million due to debt repayments [297] Goodwill and Impairment - The company recorded a non-cash goodwill impairment charge of $2.9 billion due to increased business risks and uncertainties as of March 31, 2025 [236] - The company recorded a goodwill impairment charge of $2.94 billion for the nine months ended September 30, 2025, due to an interim goodwill impairment test [312] - The company performed goodwill impairment tests resulting in total impairment charges of $2,936.8 million across various reporting units as of March 31, 2025 [347] Market and Regulatory Environment - The FDA issued a warning letter and import alert for the Indore manufacturing facility, affecting 11 products distributed in the U.S. [237] - The company faces ongoing risks related to regulatory approvals and market acceptance of new products [227] - Viatris' Developed Markets segment includes operations primarily in North America and Europe, while the Emerging Markets segment covers over 125 countries [224] Cash Flow and Liquidity - Net cash provided by operating activities decreased by $320.1 million to $1.50 billion for the nine months ended September 30, 2025, compared to $1.82 billion in 2024 [315] - Net cash used in investing activities was $216.5 million for the nine months ended September 30, 2025, a decrease of $2.19 billion from net cash from investing activities of $1.97 billion in 2024 [318] - Cash and cash equivalents totaled $975.3 million at September 30, 2025, with significant investments in U.S. government money market funds and bank deposits [322] - The company has access to $3.5 billion under the 2024 Revolving Facility, which matures in September 2029, with no borrowings outstanding as of September 30, 2025 [323] Sales Performance by Region - Net sales in Developed Markets decreased by $43.1 million, or 2%, primarily due to the Indore Impact of approximately $100 million [258] - Net sales from Greater China increased by $53.4 million, or 10%, driven by strong growth across multiple channels [259] - Emerging Markets saw an increase in net sales of $37.2 million, or 7%, primarily due to higher volumes and pricing of existing products [261] - Net sales from Greater China increased by $114.9 million, or 7%, for the nine months ended September 30, 2025, driven by strong growth across multiple channels [283] Future Projections and Estimates - The North America reporting unit had a revenue compound annual growth rate forecast of approximately 3.1% over the next 10 years [347] - The Europe reporting unit had a revenue compound annual growth rate forecast of approximately 3.3% over the next 10 years [348] - The Emerging Markets reporting unit had a revenue compound annual growth rate forecast of approximately 3.5% over the next 10 years [349] - The revenue compound annual growth rate forecasted for the next 10 years is approximately 1.6% [352]