Danaher Corporation Rainer Blair, President & CEO J.P. Morgan Healthcare Conference | January 13, 2026 Innovation at the speed of life. Forward Looking Statements Statements in this presentation that are not strictly historical, including any statements regarding Danaher's estimated or anticipated financial performance and any other statements regarding events or developments that we believe or anticipate will or may occur in the future are "forward looking" statements within the meaning of the federal secu ...

Core Insights - Beckman Coulter Diagnostics has launched the first fully automated Brain-derived Tau (BD-Tau) research use only (RUO) immunoassay test, enhancing precision medicine research for neurodegenerative diseases [1][4] - The U.S. FDA has granted Breakthrough Device Designation to Beckman Coulter's Access pTau217/-Amyloid 1-42 plasma ratio Test, indicating its potential significance in clinical diagnostics [2][6] Group 1: Product Launch and Features - The BD-Tau RUO assay is designed for use on the DxI 9000 Immunoassay Analyzer and Access 2 Analyzer, contributing to a portfolio that includes other neurodegenerative disease assays like pTau217, NfL, GFAP, and APOE 4 [1][6] - BD-Tau is identified as a promising blood-based biomarker for neurodegenerative research, showing a strong correlation with cerebrospinal fluid total tau levels, particularly in the presence of amyloid and tau tangle abnormalities [3][4] - The automated BD-Tau assay offers workflow advantages by minimizing manual intervention, thus enhancing research efficiency and consistency in clinical trials [5] Group 2: Clinical Implications and Research Potential - Elevated plasma BD-Tau levels are associated with Alzheimer's disease (AD) pathology, indicating its potential as a biomarker for early detection and monitoring of disease progression [4][6] - The combination of plasma BD-Tau with phosphorylated tau (p-tau) may refine research stratification for studying disease risk and personalized interventions in neurodegenerative diseases [4][5] - The development of the A-42 RUO immunoassay test further supports Beckman Coulter's commitment to advancing diagnostic solutions for neurodegenerative diseases [5][6]