Financial Data and Key Metrics Changes - Bruker reported Q4 2024 revenues of 979.6million,a14.63.37 billion, with CER revenue growth of 14% and organic growth of 4% [19][42] - Non-GAAP diluted EPS for Q4 2024 was 0.76,up8.60.70 in Q4 2023 [17][38] - Non-GAAP operating margin for Q4 2024 was 18.1%, matching Q4 2023, with a 300 basis point organic operating margin expansion [17][37] Business Line Data and Key Metrics Changes - BioSpin Group revenue for 2024 was 905.7million,withlowteenspercentagegrowthinCER,drivenbystrongperformanceinEuropeandtheAmericas[22]−CALIDGrouprevenuereached1.1 billion, with mid-teens percentage CER growth, primarily in microbiology and infection diagnostics [23] - Bruker NANO's revenue also hit 1.1billion,growinginthehighteenspercentageCER,supportedbysemiconductormetrology[24]−BESTrevenuesgrewinthelowsingledigitspercentage,drivenbyacceleratorandFUSIONtechnologies,butfacedsoftnessinclinicalMRIsuperconductors[25]MarketDataandKeyMetricsChanges−Americasrevenuegrewinthelowsingle−digitpercentage,whileEuropeanrevenueincreasedinthemid−teensrange,andAsiaPacificrevenuedeclinedinthehighsingle−digitpercentageyear−over−year[35]−Thecompanyexperiencedstrongmarkettrendsindiagnosticsandsemiconductormetrology,withsignsofabiopharmarecovery[14][35]CompanyStrategyandDevelopmentDirection−Brukerisfocusedonamultiyeartransformationintoagrowth−orientedindustryleader,emphasizinghighermarginpotentialandrapidEPSincreases[12][32]−Thecompanyaimsforconstantexchangeraterevenuegrowthof5189.9 million in operating cash flow in Q4 2024, with free cash flow of $151.1 million [39][40] - Bruker plans to return capital to shareholders through its existing share buyback program [40] Q&A Session Summary Question: Confidence in instrumentation sales despite NIH cuts - Management indicated that NIH funding is less than 5% of their exposure and has sufficient growth drivers outside the U.S. to support their guidance [54][56] Question: Academic government budget in Europe and China - Management noted that China is experiencing stimulus funding spread over multiple quarters, while Europe has shown reasonable performance [68][70] Question: Impact of NIH funding deterioration on margins and EPS - Management has modeled potential declines in NIH funding and believes they have built reasonable contingencies into their guidance [110][112] Question: Update on biopharma recovery timing - Management expects a gradual recovery in the biopharma sector, starting in the first half of 2025 [77] Question: Geographic concentration of backlog in BSI - The backlog is consistent with the company's geographic exposure, with a significant backlog level providing a cushion against uncertainties [83][84] Question: Operating margin expansion assumptions - Management targets around 140 basis points of expansion, factoring in organic headwinds and FX impacts [88][89]