Core Viewpoint - Marriott International is undergoing a leadership transition with the retirement of two long-time executives and the appointment of three seasoned leaders to enhance its growth strategy across global regions [2][3][15]. Leadership Changes - Liam Brown and Brian King will retire from their roles at the end of March and June 2026, respectively, after decades of service [3][4]. - Satya Anand will take over as Group President for U.S., Canada, and CALA, while Neal Jones will become President of EMEA, and Federico Greppi will lead CALA [3][15]. Contributions of Retiring Leaders - Liam Brown has nearly four decades of experience at Marriott, known for driving strategic growth and strengthening market position, particularly in franchising and brand management [4][5]. - Brian King has a three-decade career marked by transformative growth, including the acquisition of the City Express brand and expansion in the all-inclusive category, enhancing profitability in CALA [5][6]. New Leadership Profiles - Satya Anand, a 37-year veteran, has held various leadership roles and has been instrumental in driving digital transformation and growth in the EMEA region [6][7]. - Neal Jones brings three decades of experience, focusing on commercial strategy and brand positioning in EMEA, overseeing nearly 80 countries and 1,300 properties [9][10]. - Federico Greppi has over 22 years of hospitality experience, with a strong track record in operational and financial performance, and will lead CALA's growth [12][13]. Strategic Focus - The new leadership aims to foster greater alignment and collaboration across the U.S., Canada, and CALA, enhancing operational efficiency and market presence [7][15]. - The appointments are expected to position Marriott for continued growth, with a focus on innovation and strengthening owner relationships [15].

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2022 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO Commission File Number 001-36644 CALITHERA BIOSCIENCES, INC. (Exact name of Registrant as specified in its Charter) | Delaware | | 27-2366329 | | --- | --- | -- ...