不可思议的是，这些蛾子从没有随便乱飞过，它们有非常明确的目的地。过去的研究已经发现，它 们具备感知地球磁场的能力，这或许帮助它们确定出大致方向。但问题是：它们到底是怎么在茫茫黑夜 中保持精确而正确的航向？ 答案终于揭晓了。由瑞典隆德大学科学家领导的国际团队，在实验室中搭建了一个特殊的"天象 仪"装置，并屏蔽了地球磁场的影响。他们把捕获的布冈夜蛾放进去，模拟不同的星空环境，观察它们 的飞行方向。 结果令人震惊：即使没有地磁信号，这些蛾子依然能根据头顶的"星空"锁定方向，并且和它们在野 外迁徙时的方向完全一致！ 原标题：布冈夜蛾导航的秘密藏在星光里 在此之前，利用星辰进行导航的能力，只在一些鸟类、人类中被观察到。而如今，一只小小的蛾 子，也加入了这个"星际导航俱乐部"。 一只小小的飞蛾，不但能在漆黑的夜空中找到方向，还能穿越上千公里，精准抵达它从未到过 的"祖传度假胜地"。《自然》杂志上最新一篇研究揭开了这个神秘的昆虫界的"导航高手"——布冈夜蛾 的秘密：它们居然是利用星光来认路！这是人类第一次在无脊椎动物中发现这个本领。 这种名叫布冈夜蛾的小家伙，每年春天都会从澳大利亚高热的东南部出发，长途跋涉近1000公里， ...

Core Insights - The blood-brain barrier (BBB) presents significant challenges for delivering drugs to the central nervous system, particularly for neurodegenerative diseases and brain cancers [1][2] - Scientists are developing "shuttles" that can effectively transport biological drugs, such as antibodies and gene therapies, across the BBB [1][3] Group 1: Blood-Brain Barrier Challenges - The BBB acts as a protective barrier between the bloodstream and brain tissue, preventing harmful substances from entering the brain [2] - Small, lipophilic molecules can cross the BBB, but large biological drugs face significant obstacles, with less than 0.1% of certain antibody drugs reaching the brain after intravenous injection [2][3] - High doses of drugs are often required due to the low penetration rate, leading to potential waste and severe side effects [2] Group 2: Advances in Drug Delivery Technologies - Recent advancements in drug delivery systems are inspired by the brain's iron supply system, utilizing transferrin receptors to facilitate the transport of large molecules across the BBB [3][4] - Clinical projects are underway, with notable successes such as the enzyme replacement therapy for Hunter syndrome and the trontinemab antibody for Alzheimer's disease, which showed a threefold increase in amyloid clearance efficiency [3][4] - The range of deliverable "cargo" is expanding, including oligonucleotides for gene expression regulation and engineered viruses for gene therapy [4][5] Group 3: Future Prospects - The development of exosomes as natural "nanopackages" for delivering gene editing tools like CRISPR-Cas9 is gaining traction, indicating a promising future for brain-targeted therapies [5] - These innovative delivery technologies are expected to transform the medical landscape, offering new hope for patients with previously untreatable conditions [5]

Core Insights - Quark has launched the first large model specifically designed for high school entrance exam (Gaokao) application filling, providing personalized services for students [1][2] - The model aims to simplify the complex decision-making process for students and parents by offering expert-level guidance and analysis [2][4] Group 1: Model Development - The development of the Quark Gaokao Application Model involved multiple iterations, utilizing thousands of expert-annotated reports to enhance its accuracy and relevance [1][3] - The model incorporates a multi-stage training process that combines self-supervised semantic modeling and expert-guided strategy refinement [2][3] Group 2: User Experience and Functionality - The model is designed to address the diverse needs of students by providing tailored advice based on their unique profiles, interests, and family expectations [2][4] - Quark aims to democratize access to expert advice by transforming one-on-one consultations into a scalable AI-driven system [2][5] Group 3: Expert Involvement - The training process heavily relies on the insights and experiences of hundreds of volunteer experts, ensuring a comprehensive understanding of student needs [4][5] - The model categorizes common inquiries into cognitive and decision-making questions, allowing it to efficiently address a wide range of student concerns [4][5] Group 4: Future Implications - The integration of AI in the application process is expected to enhance the efficiency of human experts, creating a collaborative environment rather than a replacement scenario [5] - The ultimate goal is to provide students with a supportive tool for career planning and decision-making from an early stage, reducing anxiety during the application process [5]

Group 1 - The article emphasizes the importance of choosing a major based on personal interest and long-term career suitability rather than solely on current employment rates or popularity [1][2] - It highlights two common misconceptions in college major selection: focusing only on employment rates and blindly following trends without understanding the challenges of the chosen field [1][2] - The article provides examples of how certain majors that were once in high demand, such as civil engineering and foreign trade English, have seen a decline in job opportunities due to industry changes [1][2] Group 2 - The narrative stresses that passion and interest are crucial for long-term success and fulfillment in one's career, as illustrated by the story of Fan Jinshi, who dedicated her life to preserving Dunhuang murals [2] - It also points out that having a strong aptitude in a chosen field can lead to significant achievements, as demonstrated by mathematician Wei Dongyi, who made notable contributions to fluid mechanics [2] - The article concludes that selecting a major should be akin to choosing a comfortable pair of shoes; it should fit well with one's interests and abilities for a fulfilling journey [3]

Core Insights - The integration of technology in the broadcasting and audiovisual industry is transforming content creation and viewer experience, with significant advancements in smart production and transmission methods [1][2]. Group 1: Technological Innovations - The broadcasting industry is experiencing a shift from traditional film to digital and intelligent production, exemplified by the use of a 600-square-meter LED screen for virtual scene visualization, enabling the creation of grand visuals that were previously impossible [1]. - The emergence of generative artificial intelligence (AIGC) is leading to revolutionary changes, with companies developing their own AI tools for efficient post-production workflows in popular dramas [1]. Group 2: Enhanced Viewer Experience - The upgrade from traditional broadcasting equipment to modern devices, such as smart TVs and ultra-high-definition micro set-top boxes, is directly addressing user pain points and improving the viewing experience [2]. - A universal remote control has been developed to simplify the user experience, allowing viewers to operate their devices seamlessly with a single remote [2]. Group 3: Artistic and Technological Synergy - The combination of technology and art is showcased in major events like the Spring Festival Gala, where innovative programs like "Yang BOT" merge cutting-edge robotics with traditional Chinese art forms, generating significant public interest [2][3]. - The collaboration between engineers and creative teams over five months to produce engaging content highlights the potential of technology to enhance artistic expression and drive industry growth [3].

Core Points - The China Academy of Sciences' Purple Mountain Observatory launched two significant telescope projects aimed at enhancing the precision measurement of celestial bodies within the solar system [1][2] - The 4.2-meter ground-based dedicated celestial measurement telescope is the largest of its kind in China and is expected to be completed by 2027, focusing on high-precision measurements of faint celestial bodies [1] - The 2.5-meter multi-terminal general telescope is designed for various observational needs and is projected to be completed by 2026, serving national strategic requirements such as space safety and asset protection [2] Group 1 - The 4.2-meter telescope features large aperture, low distortion imaging, high precision positioning, and deep detection limits, supporting the autonomous construction and long-term maintenance of China's solar system celestial catalog [1] - The 2.5-meter telescope will conduct multi-band and multi-type precision measurements of both natural and artificial celestial bodies, complementing the efforts of the 4.2-meter telescope [2] - Both telescopes will work in tandem to provide comprehensive mapping of various moving celestial bodies within the solar system, with the 4.2-meter telescope focusing on distant and faint objects while the 2.5-meter telescope targets closer and faster-moving entities [2]

如今，"拉索"产出的多项成果，突破了过去的理论极限，更新了人类对于宇宙的认知，正在书写中 国人自己的宇宙观。 现在，目光从西南高原移向东北平原。 主题宣讲中，梁爱珍带来的故事，和黑土地有关。梁爱珍来自中国科学院东北地理与农业生态研究 所。 "无论有多大的困难，都要去克服，再困难还要去克服，克服就是要去做这个做不了的事。"6月19 日，由中国科学院直属机关党委主办的中国科学院"攻坚：弘扬新时代科学家精神"主题宣讲在北京举 行。中国科学院高能物理研究所研究员陈松战在讲述高海拔宇宙线观测站"拉索"的前世今生时，回忆起 了"拉索"首席科学家曹臻的这句话。 经历4代人接续奋斗，"拉索"在四川稻城海子山建成，使得中国宇宙线研究实现了跨越式发展，达 到国际领先水平。 从预研到立项再到建设，科学家团队长期坚持，克服重重困难。在这一过程中，形成了"敢想、敢 干、敢当"的"海子山精神"。 2009年，我国科研人员提出建设"拉索"设想。但是，很多人持怀疑态度。工程能否完成，科学目标 能否实现，都是问号。但曹臻坚信，只要探测灵敏度能上去，就一定会有重大发现。 建设开始后，挑战更是一个接一个。 "拉索"建在海拔4410米的海子山，在这 ...

Core Viewpoint - The AG600 "Kunlong" aircraft, developed entirely independently by China, is the world's largest civil amphibious aircraft, designed to meet the needs of forest firefighting and water rescue. Recent milestones include obtaining the type certificate from the Civil Aviation Administration of China and completing its first production flight [1]. Group 1: Development Milestones - The AG600 received its type certificate on April 20, 2023, and the first assembled aircraft rolled off the production line on May 6, 2023 [1]. - The aircraft successfully completed its production flight on May 18, 2023, and was awarded the production license on June 11, 2023 [1]. Group 2: Technical Innovations - The AG600 is equipped with four large water tanks arranged in a "田" shape, capable of holding a total of 12 tons of water, which is crucial for firefighting efficiency [2]. - The team faced challenges with uneven water filling in the tanks, leading to multiple design iterations before discovering that high-speed water flow created complex vortices that hindered filling [3][4]. - After identifying the issue, the team implemented a design with flow directing plates to ensure simultaneous filling of all tanks, achieving a water intake efficiency that meets world standards, filling 12 tons in just 20 seconds [4]. Group 3: Safety and Design Challenges - The AG600's ability to take off from water posed safety concerns, as initial tests showed inadequate takeoff speeds [5]. - A breakthrough was made when a historical document suggested that under certain conditions, the aircraft could safely return to the water if an emergency occurred during takeoff [6]. - The team conducted extensive simulations and tests, ultimately validating this approach, which led to the establishment of new safety standards for water takeoff and landing [7]. Group 4: Aerodynamic Design - The aircraft's design required innovative solutions to address the significant difference in density between air and water, which posed unique challenges for its aerodynamic and hydrodynamic integration [8]. - The design of the main landing gear's fairing was particularly challenging, as it needed to reduce aerodynamic drag while maintaining stability [9]. - The team conducted over 30,000 wind tunnel and hydrodynamic tests to refine the aircraft's design, ensuring successful flight tests and laying a solid foundation for the AG600's operational capabilities [9].

"不刷手机就会觉得特别烦躁，生活特别空虚，甚至影响睡眠。如果老年人出现这些现象，意味着可能 已经出现了医学领域所称的'行为成瘾'特征。"王华丽说。 手机等数字工具的应用在提升老年人生活便利度、丰富生活内容等方面发挥了积极作用，但成瘾后，在 身体方面，会造成老年人眼肌疲劳、影响视力，加重颈椎、肩颈的负担，导致颈椎病、肩周炎等疾病转 重；在心理方面，由于长期难以保持与其他人的人际交往水平，难以维持健康的生活节奏，老年人放下 手机后往往会受到不良情绪的困扰。 "一些网络信息平台还会向老年人推送负面不良信息，造成老年人误判误解，这对他们的身心健康会产 生更不好的影响。"王华丽建议，老年人使用手机时，在内容的选择上要有所辨别。家里人可以帮助他 们设置相关提醒，关闭一些无关紧要的推送。 "如果家里有老年人明显出现了沉迷短视频的现象，可以带他去精神科或心理科进行评估、咨询，进行 必要的治疗。"王华丽表示，老年人的心理健康问题应得到及时关注。 研究显示，约半数老年抑郁症患者到医院就诊的首次症状不是心情不好、抑郁等典型表现，而是各种各 样的身体不舒服。 "有一些老年人多次去医院看病，反复说身体不舒服，胸闷、乏力、头晕、食欲不好 ...

Core Insights - A significant breakthrough in genomics has been achieved by a team from Yale University, enhancing the ability to edit multiple DNA sites within the same cell by twofold while reducing unintended mutations in nearby gene sites [1][2] - The new technology allows for simultaneous modifications across different sections of the DNA, akin to editing multiple chapters in a vast manuscript of 3 billion characters, rather than just individual words on the same page [1] Group 1 - The research team utilized CRISPR-associated protein Cas12, which has a natural ability to handle multiple guide RNAs (gRNAs), to improve editing precision [1] - By optimizing gRNAs, including shortening their length and adjusting RNA base composition, the team significantly increased the number of edits possible within a single cell [1] - The team successfully achieved simultaneous editing of 15 different gene sites in human cells, tripling the previous capabilities of existing systems [1] Group 2 - This breakthrough is expected to aid in the understanding of complex genetic diseases such as cancer and will support the design of synthetic genomes and the development of new therapeutic drugs [2] - The research addresses key obstacles in mammalian genome editing, which is crucial for studying single nucleotide variant-related diseases and constructing synthetic mammalian genomes [2] Group 3 - The advancement lays a solid foundation for the future of precision medicine and synthetic biology [3] - Gene editing technology, often referred to as "molecular scissors," allows scientists to cut and insert specific DNA segments, making it a simple and cost-effective tool in life sciences [3] - Continuous iterations and upgrades in gene editing technology aim to enhance efficiency and precision, transitioning from "molecular scissors" to "molecular scalpels" for more significant applications in precision medicine and modern agriculture [3]