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新系统可同时在DNA多位点进行修改 基因编辑范围和精度由此扩大
Ke Ji Ri Bao· 2025-06-22 23:32
Core Insights - A significant breakthrough in genomics has been achieved by a team from Yale University, enhancing the ability to edit multiple DNA sites within the same cell by twofold while reducing unintended mutations in nearby gene sites [1][2] - The new technology allows for simultaneous modifications across different sections of the DNA, akin to editing multiple chapters in a vast manuscript of 3 billion characters, rather than just individual words on the same page [1] Group 1 - The research team utilized CRISPR-associated protein Cas12, which has a natural ability to handle multiple guide RNAs (gRNAs), to improve editing precision [1] - By optimizing gRNAs, including shortening their length and adjusting RNA base composition, the team significantly increased the number of edits possible within a single cell [1] - The team successfully achieved simultaneous editing of 15 different gene sites in human cells, tripling the previous capabilities of existing systems [1] Group 2 - This breakthrough is expected to aid in the understanding of complex genetic diseases such as cancer and will support the design of synthetic genomes and the development of new therapeutic drugs [2] - The research addresses key obstacles in mammalian genome editing, which is crucial for studying single nucleotide variant-related diseases and constructing synthetic mammalian genomes [2] Group 3 - The advancement lays a solid foundation for the future of precision medicine and synthetic biology [3] - Gene editing technology, often referred to as "molecular scissors," allows scientists to cut and insert specific DNA segments, making it a simple and cost-effective tool in life sciences [3] - Continuous iterations and upgrades in gene editing technology aim to enhance efficiency and precision, transitioning from "molecular scissors" to "molecular scalpels" for more significant applications in precision medicine and modern agriculture [3]
应急求助、危机预警……“智”造新品守护美好生活
Ke Ji Ri Bao· 2025-06-22 01:47
小屏让信息触手可及,物联让万物近在咫尺。如今,移动通信与物联网正深刻改变着人们的生产生 活方式。在6月18日到20日联动举行的2025世界移动通信大会及IOTE 2025第二十三届国际物联网展·上 海站展会现场,一系列服务百姓生活、守护人身安全的创新产品亮相。 "前方危险,注意安全!"在第二十三届国际物联网展·上海站重庆甲虫网络科技有限公司展台上 方,智能声光报警器正在播放预警信息。这是该公司研发的高精度倾斜监测仪的联动设备之一,可以帮 助山区居民在遇到自然灾害时快速撤离。 AI陪伴水杯引导孩子健康饮水且能开展智能互动,卫星电话+短报文智能终端帮助驴友在遇到紧急 情况时高效求助,高精度倾斜监测仪为山区居民提供泥石流预警,AI素描机械臂展示精湛绘画技艺解 放创作者,燃气罐监控器精准监控燃气泄漏并及时报警……这些成果在展示全球移动通信与物联网领域 最新进展的同时,通过智能互联、应急求助、危机预警、AI绘画等应用,铺展民生幸福底色,守护百 姓安全防线,共同绘制"智"造生活新图景。 AI陪伴水杯:巧妙引导孩子爱上喝水 《中国学龄儿童膳食指南(2022)》建议,低身体活动水平的6岁学龄儿童每天至少饮水800毫升, 7到 ...
自然资源部:技术赋能减轻基层负担
Ke Ji Ri Bao· 2025-06-21 23:03
Group 1 - The Ministry of Natural Resources is focusing on supporting economic provinces, optimizing investigation and monitoring work, promoting linked approval reforms, and improving farmland protection policies and real estate registration services [1] - The Ministry aims to enhance the efficiency of investigation and monitoring work by adjusting and optimizing investigation rules to reduce the burden on grassroots [1] - A collaborative mechanism for annual forest, grassland, and wetland investigation monitoring will be established by 2025 to unify standards, timing, and platforms, addressing data discrepancies and management challenges [1] Group 2 - The Ministry is addressing the issue of "simplistic and one-size-fits-all" enforcement by leveraging geospatial and mapping technology to create a national remote sensing image sharing application mechanism [2] - By 2025, the Ministry will optimize the workflow of investigation work, moving away from centralized distribution of suspected change maps to empower grassroots efforts for real-time investigations [2] - The Ministry emphasizes the importance of daily monitoring and management to alleviate the pressure of year-end concentrated investigations and ensure the authenticity of results through post-event supervision [2] Group 3 - The Ministry clarifies that land surveys are routine checks and the results only reflect the status at the time of the survey, which should not be directly used as management basis [3] - Management and enforcement should consider the legality and rationality of land use sources, integrating comprehensive management information for land use classification [3] - The Ministry is enhancing training for grassroots departments to ensure accurate understanding and application of management policies, correcting behaviors that harm farmers' interests [3]
科技日报:第二届武汉未来产业创新创业大赛启动
Ke Ji Ri Bao· 2025-06-21 07:39
Group 1 - The second Wuhan Future Industry Innovation and Entrepreneurship Competition was launched on June 19, aiming to discover and cultivate forward-looking and innovative future industry projects [1][3] - The competition focuses on key technological areas such as future manufacturing, future information, future materials, future energy, future space, and future health, inviting participation from the entire society [3][5] - The event is a significant initiative for Wuhan to implement its innovation-driven development strategy, enhancing the city's role as a national center and core city of the Yangtze River Economic Belt [3][4] Group 2 - A "Future Π" startup project growth acceleration camp was established to provide professional training and mentorship to help entrepreneurs refine their business plans and enhance project competitiveness [4] - The competition has a funding base of 1 billion yuan, supported by Wuhan Fund and Jiangcheng Fund, with partnerships established with local investment funds to facilitate project implementation [4][5] - The competition is open to innovative teams or enterprises with relevant patents and technological achievements, with registration available until mid-July 2025 [5]
着力打造“兽用疫苗研发生产第一城”
Ke Ji Ri Bao· 2025-06-21 00:51
Core Viewpoint - The city of Hohhot is striving to become the leading hub for veterinary vaccine research and production in China, driven by significant technological breakthroughs and supportive policies in the biopharmaceutical industry [1][3][5] Group 1: Technological Breakthroughs - Jin Yu Bao Ling Biopharmaceutical Co., Ltd. launched the "Jin Niu Zhi" vaccine, marking a major technological advancement in China's biopharmaceutical sector [1] - The company has also established an intelligent manufacturing line capable of producing 8 million doses of pet vaccines annually, which has passed GMP static acceptance [1] - The establishment of the Inner Mongolia Animal Vaccine Technology Innovation Center aims to enhance vaccine research and development, focusing on major animal diseases [2][3] Group 2: Industry Growth and Collaboration - Hohhot has seen its biopharmaceutical industry output grow from 13.11 billion yuan in 2020 to 20.25 billion yuan in 2024, with 117 research institutions and 602 drug registration approvals [4] - The city has actively collaborated with prestigious institutions like the Chinese Academy of Sciences and Tsinghua University to accelerate vaccine development [4] - The introduction of high-value product projects by local companies aims to enhance the quality and innovation of animal serum and vaccine production [2][4] Group 3: Policy Support and Investment - Hohhot has implemented various policies to support the high-quality development of the biopharmaceutical industry, including financial incentives totaling 14 million yuan for innovation platforms and vaccine projects [3] - The city is positioning itself as a national leader in veterinary vaccine production, with significant investments in research and development infrastructure [5] - The establishment of the National Swine Technology Innovation Center in Inner Mongolia signifies the region's commitment to becoming a key player in the animal vaccine industry [4]
稳定性媲美商业晶硅!产业级钙钛矿太阳能电池研发获关键突破
Ke Ji Ri Bao· 2025-06-20 09:26
Core Insights - The research team has developed a new technology that enhances the stability and efficiency of perovskite solar cells, achieving comparable outdoor performance to commercial silicon solar cells [1][4]. Group 1: Technological Advancements - The newly developed "gas-phase assisted surface reconstruction" technology allows for in-situ restructuring of perovskite surfaces, effectively isolating defect-rich surface units and suppressing irreversible ion migration [4]. - The power conversion efficiency of the 0.16 square centimeter cell and the 785 square centimeter module reached 25.3% and 19.6%, respectively [4]. Group 2: Market Implications - The research indicates that the expected T80 lifespan of the module can reach 2478 cycles, equivalent to over 6.7 years of operation in a 25°C environment, suggesting an outdoor lifespan exceeding 25 years [4]. - This innovation marks a significant step towards the commercialization of perovskite solar cells, addressing their previous limitations in longevity compared to silicon solar cells [3][4].
湖北鄂州:激活创新引擎 驱动产业转型
Ke Ji Ri Bao· 2025-06-20 07:52
Group 1: Company Innovations - Wuhan Tianming Intelligent Equipment Co., Ltd. has developed an automatic cutting bed that utilizes a vacuum suction platform and a nano-sensing knife head, marking a significant advancement in the textile industry [1] - Hubei Huawu Heavy Industry Group has introduced a smart debris removal robot for underground transportation belts, enhancing operational efficiency and reducing labor costs in mining [2] - Hubei Hongrun High-tech New Materials Co., Ltd. is leading a project on high-performance sodium-ion battery cathode materials, benefiting from financial support under the "racehorse system" technology projects [7] Group 2: Industry Trends - The city of Ezhou has seen a 28% increase in technology contract transaction volume and a 19.2% rise in high-tech industry added value in the first quarter of this year, indicating a strong trend towards digital transformation [1] - Ezhou's metallurgical industry, led by Baowu Group Ezhou Steel Co., Ltd., has over 20 enterprises with an annual R&D investment exceeding 1 billion yuan, contributing to a total industry output value of over 40 billion yuan [3] - The establishment of 164 technology innovation platforms in Ezhou reflects a systematic approach to promoting technological innovation across various sectors [5] Group 3: Collaborative Efforts - Ezhou has established multiple joint innovation centers with universities, enhancing the collaboration between academia and industry to drive technological advancements [3][5] - The Hubei Science and Technology Innovation Supply Chain Platform has facilitated the connection between enterprises and research institutions, leading to the development of advanced agricultural machinery [4] - The Ezhou Industrial Technology Research Institute has incubated 79 enterprises and introduced 75 research projects, showcasing the effectiveness of collaborative innovation efforts [5] Group 4: Policy Support - Ezhou's government has implemented policies to encourage R&D investment, providing financial support and guidance to local enterprises, particularly startups [6] - The National Development Bank has issued 105 million yuan in special loans to support innovation projects in local companies, demonstrating strong financial backing for technological development [6] - Ezhou's measures to incentivize technological innovation have resulted in a 18.3% year-on-year increase in high-tech industry added value, reaching 25.565 billion yuan [7]
用好气象保障“安全账” 筑牢灾害防治防线
Ke Ji Ri Bao· 2025-06-20 07:44
Core Insights - The article highlights the significant advancements in China's meteorological disaster prevention and mitigation capabilities, driven by the issuance of 1 trillion yuan in government bonds specifically for disaster recovery and enhancement of meteorological services [1][5]. Group 1: Investment in Meteorological Infrastructure - The government has approved 220 projects across 31 provinces and 4 municipalities to enhance meteorological capabilities, focusing on disaster recovery and prevention [1]. - New X-band phased array radar and upgraded meteorological disaster prevention systems have been implemented in Hainan to monitor typhoon developments [1]. Group 2: Enhanced Monitoring and Data Collection - A comprehensive meteorological monitoring network has been established, with 381 observation stations built in Chongqing to cover hazardous rock points [2]. - In Xinjiang, 58 new intelligent meteorological observation stations have been constructed to eliminate monitoring blind spots [2]. - Advanced equipment has been installed in Qinghai for weather modification operations, significantly improving monitoring capabilities [2]. Group 3: Data Processing and Forecasting Improvements - Sichuan's meteorological department has reduced the time for 3D wind field analysis from 14 minutes to 5.6 minutes through innovative GPU computing applications [3]. - Inner Mongolia's meteorological data processing capacity has increased by 40%, achieving millisecond-level data decoding [3]. - A comprehensive weather support system for the Yellow River basin has been developed in Henan, integrating data from multiple departments for real-time monitoring [3]. Group 4: Community Impact and Disaster Response - During severe weather events, such as the "8·20" heavy rain in Liaoning, new risk monitoring modules helped over 50,000 people avoid danger [4]. - In Tianjin, a timely geological disaster warning was issued 11 hours in advance, facilitating the safe relocation of over 4,000 residents [4]. Group 5: Broader Applications and Benefits - Meteorological projects are enhancing agricultural monitoring, with improved observation stations in Jilin providing real-time reports on land degradation [5]. - In Gansu, a wind power forecasting system is generating personalized reports for wind turbines, preventing significant equipment losses [5]. - The meteorological department in Heilongjiang utilized advanced forecasting to identify optimal weather conditions for sporting events [6].
我国科学家发现调控水稻抽穗期的关键基因
Ke Ji Ri Bao· 2025-06-20 07:12
Core Insights - The research team led by academician Wan Jianmin has identified a new gene, ELD1, that specifically regulates the heading date of rice under long-day conditions, which is crucial for breeding high-yield, high-quality, and widely adaptable rice varieties [1][2] - The study reveals that the ELD1 gene can significantly promote heading without causing obvious agronomic defects, indicating its potential for molecular breeding applications [2] Group 1: Gene Discovery and Mechanism - The ELD1 gene regulates the mRNA splicing of the core biological clock gene OsCCA1, affecting the heading date of rice [1] - The research indicates that shorter light exposure leads to faster heading and earlier maturity in rice [1] - ELD1 interacts with OsNKAP protein and multiple core mRNA splicing factors, influencing the splicing of thousands of genes across the genome [1] Group 2: Implications for Breeding - The study provides a new mechanism for understanding how light signals regulate the heading date of rice, which is significant for molecular breeding [2] - The team utilized base editing technology to create targeted mutations in key amino acids of ELD1, resulting in new early-heading germplasm for high-quality rice varieties such as Ningjing 7 and Ningjing 4 [2] - This research offers important genetic resources and theoretical support for addressing the late maturity issues in hybrid rice breeding [2]
史前遗址填补中华文明演进缺口
Ke Ji Ri Bao· 2025-06-20 03:07
Core Insights - The 2024 National Top Ten Archaeological Discoveries highlight significant findings that enhance the understanding of the origins and early development of Chinese civilization [1] - The discoveries include the Mengxi River site in Sichuan, the Xiantang site in Zhejiang, and the Siwa site in Gansu, each contributing unique insights into prehistoric human activities and cultural evolution [1] Group 1: Mengxi River Site - The Mengxi River site dates back 80,000 to 60,000 years and was uncovered after floods exposed ancient artifacts, leading to a significant archaeological excavation [2][3] - A total of 15,100 stone tools, 2,100 wooden artifacts, and 62,200 plant seed specimens were unearthed, providing a comprehensive view of the Paleolithic culture [2] - The unique preservation conditions of the site allowed for the coexistence of stone tools and organic remains, a rare phenomenon in archaeology [3] Group 2: Xiantang Site - The Xiantang site is recognized as China's earliest agricultural settlement, with a cultural layer thickness of 2.5 meters and an area of approximately 30,000 square meters [5] - Excavations have revealed structures such as moats, artificial platforms, and food processing areas, indicating advanced social organization in early agricultural societies [5][6] - Advanced techniques like Raman spectroscopy were used to analyze pottery, revealing insights into prehistoric pottery-making processes [5][6] Group 3: Siwa Site - The Siwa site, spanning from the Neolithic to the Bronze Age, features a complex layout with multiple rectangular moats and numerous residential structures [7][8] - The discovery of a high-status, central settlement of the Majiayao culture provides critical insights into the social and economic structures of early Chinese civilizations [8] - Technological analysis of pottery from the site suggests the presence of early porcelain, potentially rewriting the history of porcelain origins in China [9][10] Group 4: Overall Significance - These archaeological findings collectively bridge gaps in the understanding of human evolution and cultural development in East Asia, showcasing a continuous narrative from the Paleolithic to the Bronze Age [10] - The integration of multidisciplinary research methods enhances the reconstruction of early Chinese societal structures and cultural practices [6][10]