※ Market Axess® Q1 2022 Conference Call and Webcast April 20, 2022 ※ Market Axess® Strategic Update ❖Rick McVey, Chairman and CEO 2 1Q22 Strategic Update & Highlights¹ | --- | --- | |------------------------------------------------------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 10-K (Mark One) ☑ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2021 ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to None Commission File Number 001-34091 MARKETAXESS HOLDINGS INC. (Exact name of registrant as specified in its charter) Delaware 52-2230784 (State of incorporation) ...

Financial Performance & Growth - The company's revenue growth from 2016 to 2021 showed a 14% Compound Annual Growth Rate (CAGR)[4] - Operating income growth from 2016 to 2021 showed a 12% CAGR[4] - EBITDA growth from 2016 to 2021 showed a 13% CAGR[4] - The trailing 12-month free cash flow was $297 million[58] - The company returned $197 million in capital in 2021 through dividends and share repurchases[58] Market Penetration & Expansion - The company has over 1,870 active firms[28] - The company's estimated system-wide cost savings of $78 million for liquidity takers and $50 million for liquidity providers in 4Q21[36] - European client volume reached $687 billion, up 5% year-over-year[41, 43] - Emerging market volume reached $649 billion, up 16% year-over-year[41, 81] Open Trading & Automation - Open Trading credit volume reached $2717 billion in 2021, up 27%[36, 72] - Open Trading emerging markets volume reached $56 billion in 2021, up 43%[36] - Auto-X volume in 4Q21 was $444 billion, up 39% from 4Q20[45] - Auto-X represented 19% of credit trade count and 7% of credit trade volume in 4Q21[45]

Financial Data and Key Metrics Changes - MarketAxess reported fourth quarter revenue of $165 million, a 4% decrease from the prior year, attributed to a 6% decline in credit trading volume and lower fee capture [30][31] - Full year 2021 marked the 13th consecutive year of record revenues, with a 2-year compound growth rate for revenue at 17% and operating income at 16% [13][14] - Fourth quarter EBITDA was $86.3 million, and diluted EPS was $1.37 [32] Business Line Data and Key Metrics Changes - U.S. government bond volume reached a record of $4.1 trillion in 2021, with significant dealer and investor participation [11] - Municipal bond trading grew 42% to $6.6 billion in the fourth quarter, with MuniBrokers integration completed [25] - Open Trading facilitated over $15 billion in notional value daily, with nearly 1,700 firms active in the network [21] Market Data and Key Metrics Changes - Market conditions in 2021 were challenging due to historically low credit spreads and volatility, leading to a year-over-year decline in total credit market volumes [15] - Estimated market share for U.S. high-grade and high-yield is running similar to Q1 last year, while TRACE market volumes are down about 17% [17] - Emerging market share is running well above last year, with estimated volumes down about 7% [17] Company Strategy and Development Direction - The company aims to be the 1 portfolio trading provider in 2022, expanding its foundation for growth in new product areas [10] - Investments in geographic and product diversification are yielding a 24% 2-year compound revenue growth in areas outside the core U.S. corporate bond business [14] - The company is focused on enhancing its trading protocols and expanding its electronic trading solutions to capture a larger market share [23] Management's Comments on Operating Environment and Future Outlook - Management anticipates a return to more normal levels of interest rates and bond market volatility in the coming quarters [16] - The company believes that the extended period of quantitative easing has led to low volatility, which is expected to change with central banks preparing for rate increases [16] - Management expressed confidence in the future growth of electronic trading in fixed income markets, projecting that electronic market share could exceed 50% [18] Other Important Information - The company completed the acquisition of Regulatory Reporting Hub, driving post-trade services revenue to $9.4 million, up 43% year-over-year [26] - A new $150 million share repurchase program was authorized by the Board of Directors, following the exhaustion of a previous $100 million program [37] - The effective tax rate for the fourth quarter was 27.1%, with a full year effective tax rate of 22.8% [32] Q&A Session Summary Question: Expense guidance variability based on revenue changes - Management indicated that variable expenses are roughly 18% to 20% of the total expense base, allowing for adjustments based on market conditions [46][47] Question: Update on all-to-all trading for munis and rates - The all-to-all solution for munis constitutes about 46% of the muni business, with ongoing rollout for U.S. treasuries [48][49] Question: Electronifying securitized markets - Management acknowledged low electronification levels in securitized markets but sees potential for future product expansion [52] Question: Investment spend and headcount growth - Investments will focus on talent, trading system enhancements, and geographical expansion, with no items tabled for 2023 [55][56] Question: Buyback authorization and M&A outlook - The capital management strategy prioritizes investments in the trading platform while seeking opportunistic M&A opportunities [60][61] Question: Non-transactional revenue outlook - Information services are expected to continue double-digit growth, driven by new product launches [63][64] Question: Portfolio trading market evolution - Management aims to be 1 in portfolio trading, with expectations of increased demand as market volatility rises [73][74] Question: Treasury market structure and regulatory changes - Regulatory focus on the U.S. treasury market is expected to remain favorable for all-to-all trading solutions [104][105]

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-34091 MARKETAXESS HOLDINGS INC. (Exact name of registrant as specified in its charter) Delaware 52-2230784 (State or other j ...

Financial Performance - Revenues decreased by 1% to $162.1 million[2] - Operating income decreased by 16% to $74.0 million[2] - EBITDA decreased by 9% to $88.8 million[2] - Diluted EPS decreased by 15% to $1.52[2] Market Share and Volume - Estimated U S high-grade market share decreased to 21 4% from 22 2%[3] - Estimated U S high-yield market share decreased to 15 3% from 16 0%[3] - U S High-Grade TRACE volume decreased by 6% year-over-year[10] - U S High-Yield TRACE volume decreased by 3% year-over-year[10] International Growth - Emerging markets hard currency volume increased by 17% to $108.9 billion[13] - Emerging markets local markets volume increased by 25% to $45.5 billion[13] - Eurobond volume increased by 22% to $76.2 billion[13] - Eurobond estimated market share increased to 13.1% from 9.5%[13] Open Trading and Automation - Average daily Open Trading volume decreased by 5% to $2.9 billion[21] - Dealer initiated Open Trading volume increased by 20% to $59.3 billion[21] - Auto-X volume increased by 39% to a record $42 billion[26] - MarketAxess municipal bond volume increased by 92% to $5.4 billion[25] Post-Trade and Information Services - Post-trade revenue increased by 101% to $9.4 million[33] - Information services revenue increased by 13% to $9.6 million[33]

MarketAxess Holdings Inc. (NASDAQ:MKTX) Q3 2021 Earnings Conference Call October 20, 2021 10:00 AM ET Company Participants Dave Cresci - IR Manager Rick McVey - Chairman and CEO Chris Gerosa - CFO Chris Concannon - President and COO Conference Call Participants Dan Fannon - Jefferies Rich Repetto - Piper Sandler Kyle Voigt - KBW Michael Cyprys - Morgan Stanley Patrick O'Shaughnessy - Raymond James Alex Blostein - Goldman Sachs Operator Ladies and gentlemen, thank you for standing by. At this time, all parti ...

(Exact name of registrant as specified in its charter) Delaware 52-2230784 (State or other jurisdiction of incorporation or organization) FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-34091 MARKETAXESS HOLDINGS INC. UNITED STATES SECURITIES AND EX ...

MarketAxess Holdings Inc. (NASDAQ:MKTX) Q2 2021 Earnings Conference Call July 21, 2021 10:00 AM ET Company Participants Dave Cresci - IR Manager Rick McVey - Chairman and CEO Chris Concannon - President and COO Tony DeLise - CFO Conference Call Participants Rich Repetto - Piper Sandler Patrick O'Shaughnessy - Raymond James Dan Fannon - Jefferies Kyle Voigt - KBW Chris Allen - Compass Point Alex Blostein - Goldman Sachs Sean Horgan - Rosenblatt Securities Michael Cyprys - Morgan Stanley Operator Ladies and g ...

For the transition period from to UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q (Mark One) ☑ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2021 or ☐ TRANSITION REPORT PURSUANT TO SECTION 13 or 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 Commission File Number 001-34091 MARKETAXESS HOLDINGS INC. (Exact name of registrant as specified in its charter) Delaware 52-2230784 (State or other juris ...