Financial Data and Key Metrics Changes - As of September 30, 2019, the company reported cash and cash equivalents of $12.3 million, which includes gross proceeds of $3.7 million from a public offering, strengthening its financial position [56] - The net loss for Q3 2019 was $3.5 million, compared to $3.3 million in Q3 2018, equating to a loss of $0.16 per share in 2019 versus a loss of $0.20 per share in 2018 [57] - Research and development expenses for Q3 2019 were $1.6 million, down from $1.9 million in Q3 2018, focusing on ongoing clinical studies [58] Business Line Data and Key Metrics Changes - The company is advancing its lead program, pelareorep, in metastatic breast cancer, conducting two key clinical studies, AWARE-1 and BRACELET-1, which are expected to provide data supporting the Phase 3 registration program [8][9] - AWARE-1 is ongoing, with additional data expected before the end of the year, while BRACELET-1 is set to begin enrolling patients in Q1 2020 [10][21] Market Data and Key Metrics Changes - The company is seeing renewed interest from large pharmaceutical companies in oncolytic viruses, with recent deals executed by major players like Merck and BMS [41] - The systemic effect of pelareorep allows it to impact metastatic disease, a critical aspect that IV-administered oncolytic viruses have yet to prove [45] Company Strategy and Development Direction - The company aims to expand its pipeline to access additional markets with unmet needs and explore combination therapies with checkpoint inhibitors and other oncology drug classes [65] - The focus remains on demonstrating the potential synergies of pelareorep with various checkpoint inhibitors and CDK 4/6 inhibitors, which are among the fastest-growing drug classes in oncology [46] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the unique position of pelareorep within the oncolytic virus space, highlighting its ability to demonstrate efficient viral replication following systemic delivery [63] - The company anticipates a rich period of data catalysts over the next 21 months, with multiple upcoming milestones expected to enhance shareholder value [66] Other Important Information - The company announced the addition of Leonard Kruimer to its Board of Directors, bringing over 30 years of experience in corporate finance and strategy [40] - The company has seen a significant increase in its share price, which has more than doubled in the last month, leading to the exercise of warrants and additional funding [60] Q&A Session Summary Question: Additional data for AWARE-1 by the end of the year - Management confirmed that additional data from the AWARE-1 study is expected in December, focusing on T cell characterization and inflammatory cell counts [75] Question: Clarification on SITC presentation regarding biopsy timing - Management clarified that biopsies were taken before the administration of Tecentriq, confirming the virus's ability to stimulate T cell expansion [77] Question: Impact of biomarker on patient enrollment - Management indicated that the biomarker will not critically limit patient enrollment, with an anticipated screen failure of no more than one in eight [88] Question: Potential path to market for multiple myeloma program - Management discussed ongoing studies combining pelareorep with proteasome inhibitors, noting impressive responses in early trials [90] Question: Resource use going forward - Management stated that partnerships with major pharmaceutical companies have allowed for a cost-effective strategy, maintaining steady operational costs [93]

Pelareorep Clinical Development and Advantages - Pelareorep is a clinical-stage immuno-oncolytic virus delivered intravenously, promoting an inflamed tumor phenotype through immune responses[5, 8] - It is the first IV-delivered immuno-oncolytic virus to demonstrate an overall survival benefit in a randomized study[5, 14] - A predictive and prognostic biomarker derived from a simple blood draw was correlated with clinical response in a second-line pancreatic cancer study[9] - Pelareorep has competitive advantages including ease of intravenous delivery, standard dosing, and access to metastatic disease[16] - The company has identified a predictive and prognostic biomarker, making Pelareorep the only oncolytic virus with a biomarker[17] Breast Cancer Studies and Strategy - A Phase 2 metastatic breast cancer study (IND-213) showed a statistically significant increase in overall survival (OS)[10, 23] from 104 months to 174 months in the ITT population (HR = 065, p = 01)[23] - In HR+/HER2- breast cancer patients, the median OS improved from 108 months to 210 months (HR = 06, p = 01)[23] - In PgR+/HER2- breast cancer patients, the median OS improved from 108 months to 218 months (HR = 036, p = 0003)[23] - The company plans to initiate a Phase 3 registration study in metastatic breast cancer after a window of opportunity study[79] Partnerships and Financials - The company has an established partnership with Adlai Nortye to develop the Chinese market, with potential upfront and milestone payments of up to $866 million[11, 65] - The company reported CDN $142 million (USD $106 million) in cash and cash equivalents as of Q1 2019, with a financial runway of over 12 months[74]

Oncolytics Biotech, Inc. (NASDAQ:ONCY) Oncolytics Co-Development Agreement Call June 5, 2019 8:30 AM ET Company Participants Michael Moore – Vice President-Investor Relations and Corporate Communications Matt Coffey – President and Chief Executive Officer Andrew de Guttadauro – President-Oncolytics Biotech U.S. and Global Head of Business Development Kirk Look – Chief Financial Officer Conference Call Participants John Newman – Canaccord Genuity Wangzhi Li – Ladenburg Thalmann Tom Shrader – BTIG Chad Messer ...

| --- | --- | |---------------------------------------------|-------| | | | | | | | Investor Presentation April 2019 | | | oncolyticsbiotech.com Nasdaq ONCY TSX | | Forward Looking Statements This presentation contains certain forward looking statements relating to the company's business prospects and the development and commercialization of pelareorep, a first-in-class systemically administered immuno-oncology agent for solid tumors and heme malignancies. These statements are based on management's current ...

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 20-F | o | REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 | | --- | --- | | | OR | | x | ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 | | | For fiscal year ended | | | December 31, 2018 | | | OR | | o | TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 | For the transition period from ____ to ____ OR o SHEL ...

Oncolytics Biotech Inc. (NASDAQ:ONCY) Q4 2018 Results Earnings Conference Call March 8, 2019 8:30 AM ET Company Participants Michael Moore - VP of IR & Corporate Communications Matthew Coffey - President, CEO Kirk Look - CFO Conference Call Participants Wangzhi Li - Ladenburg Thalmann Operator Good morning. My name is Michelle, and I will be your conference operator today. At this time, I would like to welcome everyone to the Oncolytics Biotech Fourth Quarter Results Conference Call. All lines have been pla ...