An Independent Data and Safety Monitoring Board (DSMB) Recently Evaluated the Interim Patient Safety Database for Oral Simufilam in On-going Phase 3 Trials. The DSMB Recommended Both Phase 3 Trials Continue as Planned, Without Modification. Final Clinical Safety Data for Simufilam Are Expected at the Conclusion of the Phase 3 Program. AUSTIN, Texas, Sept. 24, 2024 (GLOBE NEWSWIRE) -- Cassava Sciences, Inc. (Nasdaq: SAVA), a biotechnology company focused on Alzheimer's disease, today announced the completion ...

Cassava Sciences Today SAVA Cassava Sciences $21.85 -4.17 (-16.03%) 52-Week Range $8.79 ▼ $42.20 Price Target $119.00 Add to Watchlist Cassava Sciences NASDAQ: SAVA has become a hot topic among traders and active market participants thanks to its recent surge in volatility, liquidity, and overall market performance. Over the past month, shares have climbed 133% and are now more than 190% above their 52-week low. With its recent spike and increasing volatility and popularity in the headlines, the question ar ...

J Studios/DigitalVision via Getty Images Investment Overview Austin, Texas-based Cassava Sciences, Inc. (NASDAQ:SAVA) announced its Q2 2024 earnings today, and in early trading today, shares have dipped in value by ~5%, falling to $29 per share, which translates to a market cap valuation for the company of $1.4bn. I last covered Cassava in early July, discussing the indictment of a key Cassava advisor, Dr. Hoau-Yan Wang, for alleged fraud. In that note, I gave Cassava stock a "hold" rating. However, shares ...

Last month, we took a look at three biotech stocks following a historically bullish month for biotech exchangetraded fund (ETF) SPDR S&P Biotech ETF (XBI). Today, we'd will take a look at two more biotech names as they stage outsized moves in opposing directions. TG Therapeutics Inc (NASDAQ:TGTX) stock is up 23.2% to trade at $21.20 at last check, and headed for its largest single-day percentage gain since February, after the company's second-quarter earnings beat estimates by 157%. On the charts, TGTX shar ...

Cassava Sciences (NASDAQ:SAVA) stock is a hot topic among traders on Tuesday alongside a few important pieces of news that investors need to know about this morning. First off, traders will note that SAVA is a trending stock today. This had it claiming one of the top 10 spots on Yahoo Finance's Trending Tickers tab earlier this morning. While interest has waned a little since then, investors are still wondering what's behind the extra attention for the stock. One thing that's worth noting is that SAVA stock ...

AUSTIN, Texas, Aug. 01, 2024 (GLOBE NEWSWIRE) -- Cassava Sciences, Inc. (Nasdaq: SAVA), a clinicalstage biotechnology company focused on Alzheimer's disease, announced today that it will hold a conference call on Thursday, August 8th at 8:30 a.m. Eastern Time. Event details follow: Date: Thursday, August 8th Time: 8:30 a.m. Eastern Time Audio Webcast: https://www.CassavaSciences.com/company-presentations Or Audio Webcast: https://edge.media-server.com/mmc/p/zjvmjjcr A replay of the audio webcast will also b ...

Core Viewpoint - Cassava Sciences is extending trials for its Alzheimer's treatment candidate simufilam by up to 36 months, following recent executive resignations and fraud charges against a research collaborator, which raises concerns about the company's credibility and future growth prospects [1][4][10]. Group 1: Trial Extension and Company Response - The company announced the extension of open-label trials in its ongoing Phase 2 and Phase 3 clinical programs, allowing previous participants to continue treatment with simufilam [10]. - Executive Chairman Rick Barry emphasized that extending the trial is a significant commitment aimed at benefiting patients [7]. Group 2: Stock Performance and Market Sentiment - SAVA stock has seen notable growth recently, with shares up more than 1% on the day and over 50% in the past five days, despite a 25% decline over the last six months [6][10]. - The recent stock surge appears to be driven by speculative trading rather than substantial positive developments, suggesting a potential return to previous levels if momentum fades [8][10]. Group 3: Challenges and Scrutiny - The company continues to face scrutiny regarding the integrity of its clinical data, which may hinder investor confidence despite the trial extension [10]. - The troubled history of Cassava, including its past as a meme stock, complicates its growth prospects and investor sentiment [6][10].

Cassava is currently running two double-blind, randomized, placebo-controlled studies of simufilam in patients with mild-to-moderate Alzheimer's disease dementia. RETHINK-ALZ is a 52-week trial in which 804 patients were randomized 1:1 between simufilam 100 mg and placebo. REFOCUS-ALZ is a 76-week trial in which 1,125 patients were randomized 1:1:1 between simufilam 100 mg, simufilam 50 mg, and placebo. The trials are being conducted at 172 clinical sites in the United States, Canada, Puerto Rico, Australia ...

Core Viewpoint - Cassava Sciences, Inc. is extending its open-label extension trials for simufilam in Alzheimer's disease by up to 36 months, allowing patients to continue treatment while awaiting results from ongoing Phase 3 trials [2][8]. Group 1: Trial Details - The company is currently conducting two double-blind, randomized, placebo-controlled studies: RETHINK-ALZ, a 52-week trial with 804 patients, and REFOCUS-ALZ, a 76-week trial with 1,125 patients [4]. - The trials are being conducted at 172 clinical sites across the United States, Canada, Puerto Rico, Australia, and South Korea [4]. Group 2: Patient Commitment - Approximately 89% of patients in the ongoing Phase 3 program have chosen to continue with open-label treatment after completing the blinded trials [15]. - Prior to this extension, around 100 patients who completed the open-label Phase 3 extension trial had no option but to discontinue treatment, but they will now have the opportunity to re-enroll [15]. Group 3: Additional Monitoring - The company plans to incorporate cognition and plasma biomarker monitoring into the open-label extension trials to gather long-term data on the effects of simufilam treatment [9][10]. Group 4: Company Statements - Cassava's Executive Chairman, Rick Barry, emphasized the commitment to patients in expanding the open-label extension studies [3]. - Chief Medical Officer, James Kupiec, stated that the decision to expand the trials was in direct response to requests from clinical research sites [11]. Group 5: Future Expectations - The company expects to announce top-line results of the RETHINK-ALZ trial by the end of 2024 and for the REFOCUS-ALZ trial around mid-2025 [11].

Mr. Barry succeeds Remi Barbier, the Company's Chairman, President and CEO, who resigned from the Company and the Board. Mr. Barbier will remain employed by the Company until September 13, 2024 in a nonexecutive capacity, without duties or responsibilities. "As a public company, and one dedicated to developing a drug for Alzheimer's disease, we hold ourselves to the highest standards," Mr. Barry said. "While our priority remains the development of a potentially effective treatment for Alzheimer's disease, t ...