Financial Performance - Total revenue for the three months ended September 30, 2024, was 6,507,000,adecreaseof1.46,599,000 for the same period in 2023[9] - The net loss for the three months ended September 30, 2024, was 51,107,000,comparedtoanetlossof28,610,000 for the same period in 2023, representing an increase in loss of 78.4%[9] - The company reported a comprehensive loss of 50,266,000forthethreemonthsendedSeptember30,2024,comparedtoacomprehensivelossof28,171,000 for the same period in 2023[9] - The company had a basic net loss per share of 0.17forthethreemonthsendedSeptember30,2024,comparedto0.10 for the same period in 2023[9] - The net loss for the nine months ended September 30, 2023, was 99,248,000,comparedtoanetlossof128,647,000 for the same period in 2024, indicating a decrease in losses[15] Operating Expenses - Total operating expenses for the three months ended September 30, 2024, were 100,170,000,anincreaseof62.861,489,000 in the same period of 2023[9] - Research fees for the nine months ended September 30, 2024, were 21,516,000,comparedto26,812,000 for the same period in 2023, reflecting a decline of 19.8%[9] - Research and development expenses for the nine months ended September 30, 2024, totaled 121,183,000,adecreaseof4.6127,036,000 in the same period of 2023[9] - The company experienced a significant increase in depreciation, amortization, and impairment expenses, which rose to 36,919,000forthethreemonthsendedSeptember30,2024,comparedto5,735,000 for the same period in 2023[9] - The company reported a depreciation expense of 10,437,000fortheninemonthsendedSeptember30,2024,comparedto8,874,000 in 2023[15] Cash Flow and Liquidity - Cash used in operating activities for the nine months ended September 30, 2023, was 24,266,000,whileitincreasedto100,556,000 in 2024[15] - Total cash, cash equivalents, and restricted cash at the end of the period was 199,712,000forSeptember30,2023,downfrom153,930,000 in 2024[15] - Cash flows from investing activities resulted in a net cash used of 196,785,000fortheninemonthsendedSeptember30,2024,comparedtoanetcashprovidedof85,706,000 in 2023[15] - The company holds marketable securities totaling 516.5millionasofSeptember30,2024,withaweightedaveragelifeofapproximately0.5years[47]ShareholderEquity−Thetotalshareholders′equityasofSeptember30,2024,was1,078,094,000, a decrease from 1,152,318,000asofDecember31,2023[11]−Theweighted−averagecommonsharesoutstandingforthethreemonthsendedSeptember30,2024,were294,851,945,comparedto289,496,841forthesameperiodin2023[9]−Theweighted−averagecommonsharesoutstandingincreasedfrom288,750,387intheninemonthsendedSeptember30,2023,to293,930,702in2024[22]GovernmentContributions−TheCompanyenteredintomulti−yearcontributionagreementswiththeGovernmentofCanadaandtheGovernmentofBritishColumbiatotalingCAD300.0 million (222.3million)todevelopantibodymedicinesandenhancecapabilitiesinCanada[52]−TheGovernmentofCanadacommitteduptoCAD225.0 million (166.7million),withCAD56.2 million (41.6million)beingnon−repayableandtheremainingamountsbeingrepayablestartingin2033[52]−TherepayablefundingfromtheGovernmentofCanadaispayableoverfifteenyears,withaconditionallyrepayableportionbasedonapercentageoftheCompany′srevenue[52]−TheGovernmentofBritishColumbiacommitteduptoCAD75.0 million (55.6million),includingCAD37.5 million (27.8million)foreligibleinfrastructureinvestmentsandaconditionalportionbasedonachievingdefinedmilestones[52]−TheCompanyrecordedCAD57.2 million (42.4million)fromtheGovernmentofCanadafundingandCAD37.2 million (27.6million)fromtheGovernmentofBritishColumbiafundingasofSeptember30,2024[52]−ThetotaldeferredgovernmentcontributionsrecognizedontheconsolidatedbalancesheetsasofSeptember30,2024,amountedtoCAD149.9 million (112.5million)[53]−Governmentcontributionsareamortizedintootherincomeoveranaveragelifeofapproximately8years[53]OtherFinancialMetrics−Thecompanyrecognizedagainof16.5 million from the disposal of non-marketable securities in the quarter ended September 30, 2024[41] - The fair value of contingent consideration liabilities related to Trianni increased to 20.2millionasofSeptember30,2024,from20.0 million at the beginning of the period[43] - The company incurred lease expenses of 4,000,000forboththethreeandninemonthsendedSeptember30,2024,consistentwiththepreviousyear[29]−StockoptionsoutstandingunderthePre−IPOPlandecreasedto27,263,018sharesasofSeptember30,2024,from30,647,575sharesasofDecember31,2023[33]−Stock−basedcompensationexpensefortheninemonthsendedSeptember30,2024was52.4 million, up from $47.7 million for the same period in 2023[37] Market Risk - The Company believes its exposure to market risk has not changed materially since the last annual report[109]