Financial Performance - Net cash flow from operating activities rose to 2,875.5millionin2024,an85.91,547.2 million in 2023[491]. - Cash and cash equivalents increased to approximately 2.4billionasofDecember31,2024,comparedtoapproximately1.0 billion as of December 31, 2023, primarily due to operational cash generation and proceeds from asset sales[486]. - The company reported a decrease of 259.3millioninaccountsreceivable,net,relatedtoongoingoperations[488].InvestmentActivities−Thecompanyincurredanetcashoutflowof799.2 million in investing activities in 2024, a significant decrease from 4,101.0millionin2023,primarilyduetocashpaymentsfortheacquisitionofHI−Bio[491].−Cashgeneratedfromoperationsincluded437.5 million received from Samsung BioLogics related to the sale of a 49.9% equity interest in Samsung Bioepis[486]. - The increase in cash and cash equivalents was offset by 1.15billionusedfortheacquisitionofHI−Bioand650.0 million for the repayment of the 2023 Term Loan[486]. Debt and Liabilities - The current portion of debt increased by 1.6billion,primarilyduetothereclassificationof1.75 billion of Senior Notes from long-term to short-term[488]. - As of December 31, 2024, the company's outstanding long-term debt was 4,547.2million[496].−Thecompanyhasaccruedincometaxliabilitiesofapproximately234.0 million under the Transition Toll Tax as of December 31, 2024[520]. Acquisitions and Future Commitments - The company recognized 279.3millionofshort−termcontingentconsiderationfromtheacquisitionofHI−Bio,contributingtoa184.1 million increase in accrued expenses[488]. - The company may pay up to 650.0millioninpotentialfuturemilestonepaymentsrelatedtotheacquisitionofHI−Bio,withanacquisition−datefairvalueofapproximately485.1 million[513]. - The company could trigger potential future milestone payments of up to approximately 3.8billionbasedondevelopmentplansasofDecember31,2024[515].CapitalExpendituresandFacilities−ThecompanyisconstructinganewmanufacturingfacilityinNorthCarolinawithanestimatedtotalinvestmentof195.0 million, expected to be completed in 2025[502]. - The company has approximately 509.2millionincancellablefuturecommitmentsbasedonexistingCROcontractsasofDecember31,2024[518].RevenueRecognitionandAccountingPractices−Thecompanyrecognizesproductrevenuewhenthecustomerobtainscontroloftheproduct,typicallyupondelivery[527].−Thecompanyamortizesintangibleassetsrelatedtomarketedproductsusingtheeconomicconsumptionmethodbasedonrevenuegeneratedfromthoseproducts[542].−Thefairvalueofcontingentconsiderationfrombusinesscombinationsisrevaluedeachreportingperiod,withchangesrecordedasadjustmentstogainorlossonfairvalueremeasurement[544].ImpairmentandReserves−FortheyearendedDecember31,2024,impairmentchargesincurredwereapproximately60.2 million related to clinical programs acquired from Reata and Samsung Bioepis[541]. - The company estimates reserves for discounts and allowances based on historical experience, current contractual requirements, and market trends[530]. - As of December 31, 2024, a 10.0% change in discounts, contractual adjustments, and reserves would have resulted in a decrease of pre-tax earnings by approximately $351.9 million[531].