Revenue Performance - Q4 2024 total revenues reached 53.2million,representinga17198.8 million, a 3% increase from 192.6millionin2023[10]−FanaptnetproductsalesforQ42024were26.6 million, an 18% increase compared to Q4 2023[6] - HETLIOZ net product sales decreased by 23% to 76.7millionforthefullyear2024duetogenericcompetition[10]−Fullyear2025revenueisexpectedtogrowtobetween210 million and 250million[5]−Psychiatryportfoliorevenueisprojectedtoexceed750 million by 2030[5] - Fanapt® net product sales increased to 26,649,000inQ42024from22,599,000 in Q4 2023, representing a growth of 9.1%[26] - HETLIOZ® net product sales decreased to 20,044,000inQ42024from21,072,000 in Q4 2023, a decline of 4.9%[26] - PONVORY® net product sales surged to 6,492,000inQ42024from1,600,000 in Q4 2023, marking a significant increase of 304.5%[26] - Total revenues for Q4 2024 reached 53,185,000,upfrom45,271,000 in Q4 2023, reflecting a growth of 17.5%[26] Expenses and Losses - Operating expenses for Q4 2024 totaled 63,464,000,comparedto52,365,000 in Q4 2023, an increase of 21.2%[26] - Vanda's net loss for Q4 2024 was 4.9million,comparedtoanetlossof2.4 million in Q4 2023[14] - Net loss for Q4 2024 was 4,912,000,comparedtoanetlossof2,400,000 in Q4 2023, indicating a worsening of 104.2%[26] Cash and Assets - Cash and cash equivalents totaled 374.6millionasofDecember31,2024,adecreaseof1.6 million from the previous quarter[10] - Cash and cash equivalents decreased to 102,316,000asofDecember31,2024,downfrom135,821,000 as of December 31, 2023[28] - Total assets increased to 656,204,000asofDecember31,2024,comparedto648,440,000 as of December 31, 2023[28] - Stockholders' equity decreased to 538,546,000asofDecember31,2024,downfrom544,910,000 as of December 31, 2023[28] - The company reported a total accumulated deficit of 174,292,000asofDecember31,2024,comparedto155,392,000 as of December 31, 2023[28] Future Plans - Vanda submitted a New Drug Application (NDA) for Bysanti for bipolar disorder and schizophrenia expected in Q1 2025[5] - The company plans to submit a Biologics License Application (BLA) for imsidolimab in 2025 for generalized pustular psoriasis[11]