Revenue and Financial Performance - Revenue increased by 11.6% compared to 2023[248] - Consolidated revenue for the year ended December 31, 2024, was 660,566,000,representinganincreaseof11.6591,643,000 in 2023[273] - Net revenue for 2024 reached 660,566,anincreaseof11.7591,643 in 2023[329] - Gross profit for 2024 was 290,100,000,withagrossprofitmarginof43.978,726, a reduction from the net loss of 87,968in2023,indicatingimprovedfinancialperformance[329]−AdjustedEBITDAimprovedby36.1 million to positive 39.6millioncomparedto2023[248]−AdjustedEBITDAfor2024was39,608,000, significantly higher than 3,486,000in2023,reflectingimprovedoperationalperformance[296]OperationalEfficiencyandCostManagement−Costofrevenuefor2024was370,466,000, which is 56.1% of revenue, down from 58.7% in 2023, indicating improved efficiency[275] - General and administrative expenses increased to 259,737,000in2024,accountingfor39.331,159,000 in 2024, representing 4.7% of revenue, compared to 4.6% in 2023[281] - Sales and marketing expenses increased to 84,652,000in2024,whichis12.86,658,000 in 2024, representing 1.0% of revenue, down from 2.0% in 2023[286] - The company is committed to improving operational efficiency and achieving positive cash flow from operations[249] Cash Flow and Liquidity - For the year ended December 31, 2024, cash provided by operating activities was 7.0million,a9.0 million increase compared to cash used of 2.0millionin2023,primarilydrivenbyanimprovementingrossprofitof45.5 million[299] - Cash provided by investing activities was 12.9millionfortheyearendedDecember31,2024,asignificantdecreasefrom76.7 million in 2023, due to a 58.3milliondecreaseinsalesandmaturitiesofmarketablesecurities[300]−AsofDecember31,2024,thecompanyhad367.0 million in cash and cash equivalents, along with 19.8millioninmarketablesecurities,sufficienttosupportoperationalliquidityneedsforatleastthenext12months[302]−ThenetchangeincashandcashequivalentsfortheyearendedDecember31,2024,was24.5 million, compared to a net change of 79.3millionin2023[298]−Thecompanyexperienceda16.1 million reduction in cash used by operating activities year-over-year, attributed to improved operating results[299] Investments and Future Plans - The company plans to invest in information technology and automation to drive down testing costs[247] - The company anticipates capital expenditures for the year ended December 31, 2025, to be in the range of 30millionto35 million, following approximately 41.1millionspentoncapitalequipment,software,andleaseholdimprovementsin2024[305]MarketandRegulatoryEnvironment−TheFDAannouncedafinalruleontheregulationofLaboratoryDevelopedTests(LDTs)onApril29,2024,impactingtheregulatorylandscape[252]−Inflationdidnothaveamaterialeffectonthecompany′sbusinessduringtheyearsendedDecember31,2024,2023,and2022,butongoinginflationarypressuresmayimpactfuturefinancialresults[307]−Thecompanydoesnothedgeforeigncurrencyexchangerisks,whichprimarilyinvolveoperationsintheUnitedKingdom,andcurrentlydoesnotconsidertheseriskssignificant[311]SegmentPerformance−Thecombinedsegmentaccountedfor100201.3 million of 2025 Convertible Senior Notes at a stated interest rate of 1.25%, with net proceeds of approximately 194.5millionafterdiscountsandexpenses[426]−Theeffectiveinterestrateonthe2025ConvertibleNotesis1.96340.335 million, compared to $538.198 million in 2023, indicating a significant reduction in long-term debt[412]