Financial Performance - Total sales for 2024 were 23,875million,aslightdecreaseof0.0623,890 million in 2023[318]. - Gross profit for 2024 was 14,206million,upfrom14,034 million in 2023, reflecting a gross margin improvement[318]. - Operating profit decreased to 4,863millionin2024from5,202 million in 2023, a decline of 6.5%[318]. - Net earnings from continuing operations for 2024 were 3,899million,down7.64,221 million in 2023[318]. - Basic net earnings per common share from continuing operations were 5.33in2024,comparedto5.70 in 2023, a decrease of 6.5%[318]. - Comprehensive income for 2024 was 2,429million,downfrom4,914 million in 2023, reflecting a decline of 50.6%[322]. - Total revenue for the year ended December 31, 2024, was 23.875billion,withrecurringrevenuecontributing19.366 billion[384]. - North America generated 10.295billionintotalrevenuefor2024,whilehigh−growthmarketscontributed6.870 billion[384]. - The unaudited pro forma sales for 2024 and 2023 were 23.933billionand24.427 billion, respectively, with net earnings from continuing operations of 3.892billionand4.138 billion[370]. - The diluted net earnings per common share from continuing operations for 2024 and 2023 were 5.28and5.54, respectively[370]. Assets and Liabilities - As of December 31, 2024, the total assets of the Company were 77,542million,adecreasefrom84,488 million in 2023[315]. - The Company's cash and equivalents decreased to 2,078millionin2024from5,864 million in 2023[315]. - The Company reported total current liabilities of 6,798millionin2024,downfrom8,274 million in 2023, indicating a reduction of approximately 17.9%[315]. - The Company's long-term debt decreased to 15,500millionin2024from16,707 million in 2023, a decline of approximately 7.2%[315]. - The total stockholders' equity decreased to 49,550millionin2024from53,490 million in 2023, a decrease of approximately 7.3%[315]. - As of December 31, 2024, the Company reported total inventories of 2,330million,adecreasefrom2,594 million in 2023[336]. - The Company’s net property, plant, and equipment increased to 4,990millionin2024from4,553 million in 2023[338]. - The Company’s total financing receivables were 141millionand133 million as of December 31, 2024, and 2023, respectively[335]. - The identifiable assets for the Biotechnology segment decreased from 37.421billionin2023to34.605 billion in 2024[393]. - As of December 31, 2024, total debt amounted to 16,005million,adecreasefrom18,402 million in 2023, with long-term debt at 15,500million[429].CashFlowandInvestments−Totalcashprovidedbyoperatingactivitieswas6,688 million in 2024, slightly up from 6,490millionin2023[327].−Cashusedininvestingactivitiesfromcontinuingoperationswas1,981 million in 2024, significantly lower than 7,048millionin2023[327].−TheCompanymademinorityinvestmentstotaling331 million, 172million,and523 million in equity method investments and non-marketable equity securities in 2024, 2023, and 2022, respectively[339]. - The Company acquired three businesses in 2024 for a total cash consideration of 558million,recording305 million of goodwill related to these acquisitions[366]. - On December 6, 2023, the Company acquired Abcam plc for approximately 5.6billion,generatingrevenuesofabout£362millionin2022,andrecorded3.9 billion of goodwill from this acquisition[367]. - The Company repurchased common stock totaling 5,979millionin2024,comparedtonorepurchasesin2023[327].−DuringtheyearendedDecember31,2024,theCompanyrepurchasedapproximately20.0millionsharesofcommonstockforapproximately5.2 billion as part of the Completed Repurchase Program[483]. - The New Repurchase Program, approved on July 22, 2024, allows for the repurchase of up to 20 million shares, with 16.5 million shares remaining available as of December 31, 2024[484]. - In January 2025, the Company repurchased 4.5 million shares for approximately 1.1billionundertheNewRepurchaseProgram[484].Taxation−Theprovisionforincometaxesfromcontinuingoperationsfor2024was747 million, compared to 823millionin2023[396].−Theeffectiveincometaxratefor2024is16.11.3 billion in 2024, down from 1.8billioninboth2023and2022[399].−AsofDecember31,2024,grossunrecognizedtaxbenefitstotaledapproximately1.2 billion, consistent with the previous year[401]. - The company recognized net tax expenses from potential interest and penalties of approximately 40millionin2024,comparedto32 million in 2023 and 14millionin2022[401].−Thecompanyexpectsapotentialreductionofunrecognizedtaxbenefitsbyapproximately305 million within 12 months due to resolution of worldwide tax matters[406]. - Tax benefits from rulings and tax holiday arrangements in Puerto Rico and Singapore amounted to 33million,83 million, and 71millionfor2024,2023,and2022,respectively[407].DebtandFinancing−TheCompanyreplaceditsexisting5.0 billion unsecured revolving credit facility with a new facility expiring on August 11, 2028, which includes an expansion option of up to 2.5billion[430].−Theweightedaverageannualinterestrateforborrowingsundertheeuro−denominatedcommercialpaperprogramswas3.3965 million classified as long-term debt under euro-denominated commercial paper programs, despite being scheduled to mature within one year, due to the intent and ability to refinance[435]. - The Credit Facility requires maintaining a Consolidated Leverage Ratio of 0.65 to 1.00 or less, with no borrowings outstanding as of December 31, 2024[433]. - The Company expects to limit borrowings under the Credit Facility to ensure sufficient capacity to repay outstanding commercial paper as it matures[431]. - Debt discounts, premiums, and related costs totaled 96millionasofDecember31,2024,downfrom107 million in 2023[429]. - The Company has unconditionally guaranteed the obligations of its subsidiaries under the Credit Facility, which is available for liquidity support and general corporate purposes[434]. - The company may redeem certain notes prior to maturity by paying the principal amount plus accrued interest, with specific conditions for redemption based on adverse changes in tax laws[437]. - A change of control triggering event allows holders of certain notes to require the Company to repurchase them at a price equal to 101% of the principal amount plus accrued interest[438]. Environmental and Legal Matters - The Company has recorded a reserve of 175millionforenvironmentalmatters,ofwhich150 million are noncurrent, reflecting the best estimate of costs to be incurred[479]. - The Company actively pursues insurance recoveries for environmental liability claims but does not recognize any recoveries until realized[480]. - The Company has been identified as a potentially responsible party for certain environmental cleanup sites, which may lead to additional costs[477]. - The Company maintains various insurance coverages, but these may be insufficient to cover all potential losses from litigation and environmental claims[474]. Pension and Employee Benefits - The funded status of the U.S. pension plan improved to 211millionin2024from31 million in 2023, primarily due to increases in discount rates[453]. - The fair value of plan assets for the U.S. pension plan increased to 1.914billionin2024from1.889 billion in 2023[453]. - Projected benefit obligation for U.S. pension benefits decreased from 92millionin2023to85 million in 2024, while non-U.S. pension benefits decreased from 977millionto865 million[454]. - The discount rate for U.S. pension benefits increased from 5.1% in 2023 to 5.6% in 2024, while the rate for non-U.S. pension benefits remained at 3.5%[456]. - The expected long-term return on U.S. defined benefit pension plan assets is maintained at 6.8% for 2025, reflecting the asset allocation strategy[461]. - The company expects cash contributions of approximately 8millionforU.S.definedbenefitpensionplansand35 million for non-U.S. plans in 2025[469]. - Total expected benefit payments for U.S. pension plans in 2025 are projected to be 170million,withtotalpaymentsacrossallplansamountingto239 million[470]. - Unrecognized actuarial losses for pension plans as of December 31, 2024, amount to approximately 399million,whichwillimpactfuturenetperiodicpensioncosts[459].−Thecompany’sexpensesforalldefinedbenefitanddefinedcontributionpensionplanstotaled282 million in 2024, up from 219millionin2023[471].−Themedicaltrendrateforpostretirementbenefitsincreasedfrom5.92,693 million, slightly down from $2,704 million in 2023[464].