Revenue Performance - Total revenue for Q4 2024 increased by 19.1% to 88.3million,comparedto74.1 million in Q4 2023[3] - Software revenue for Q4 2024 rose by 16.0% to 79.7million,drivenbyincreasedhostedrevenuefromlargecustomers[3]−DrugdiscoveryrevenueforQ42024was8.7 million, a 58% increase from 5.5millioninQ42023[3]−Full−year2024totalrevenuedecreasedby4.2207.5 million, while software revenue increased by 13.3% to 180.4million[7]−Drugdiscoveryrevenueforthefullyearwas27.2 million, down 53% from 57.5millionin2023[7]−TotalrevenuesfortheyearendedDecember31,2024,were207.539 million, a decrease of 4.9% compared to 216.666millionin2023[35]−Softwareproductsandservicesrevenueincreasedto180.365 million in 2024, up 13.3% from 159.124millionin2023[35]−Drugdiscoveryrevenuedecreasedsignificantlyto27.174 million in 2024, down 52.8% from 57.542millionin2023[35]ProfitandLoss−Thecompanyreportedanetlossof40.2 million for Q4 2024, compared to a net loss of 30.7millioninQ42023[6]−Thecompanyreportedanetlossof187.123 million for 2024, compared to a net income of 40.720millionin2023[35]−Non−GAAPnetlossfortheyearwas(191,394,000) in 2024, compared to (157,755,000)in2023[41]Expenses−Grossprofitfor2024was132.083 million, a decrease from 140.692millionin2023[35]−Researchanddevelopmentexpensesroseto201.785 million in 2024, an increase of 11% from 181.766millionin2023[35]−Thedepreciationandamortizationexpenseincreasedto6,159,000 in 2024 from 5,552,000in2023[39]CustomerMetrics−Schro¨dinger′stotalannualcontractvalue(ACV)increasedby23.7190.8 million in 2024[10] - The number of customers with an ACV of at least 5millionincreasedfromfourtoeight[10]−Customerretentionrateforcustomerswithanannualcontractvalue(ACV)ofatleast100,000 is calculated based on the number of active customers from the previous fiscal year[26][27] - Active customers are defined as those with an ACV of at least 1,000,excludinglow−costsoftwareusers[28]CashFlowandInvestments−Cashflowsfromoperatingactivitiesresultedinanetcashusedof157,368,000 in 2024, an increase from 136,733,000in2023[39]−Netcashprovidedbyinvestingactivitieswas148,836,000 in 2024, down from 193,034,000in2023[39]−ThecompanyissuedcommonstockinanATMoffering,raising8,868,000 in 2024[39] - The company reported a cash and cash equivalents balance of 162,657,000attheendof2024,slightlyupfrom161,066,000 at the end of 2023[39] Future Outlook - For 2025, software revenue is expected to grow by 10% to 15%, with drug discovery revenue projected between 45millionand50 million[13] - Forward-looking statements indicate expectations for continued investment in research and growth in software licensing and drug discovery programs through 2025[31] Collaborations and Programs - Schrödinger ended 2024 with 13 ongoing programs eligible for royalties, up from 12 the previous year[11] - The company has tracked a cumulative number of collaborators for drug discovery since 2018, focusing on those collaborations that have generated revenue[30] Accounts Receivable - The company experienced a significant decrease in accounts receivable, net, amounting to (169,700,000)in2024,comparedto(10,039,000) in 2023[39] Equity Investments - The company recorded a gain on equity investments of $147,213,000 in 2023, which was not repeated in 2024[39]