ZAI LAB(ZLAB) - 2024 Q4 - Annual Report

Financial Performance - In 2024, the company reported a total revenue of $399.0 million, representing a 50$266.7 million in 2023[445]. - The net loss decreased by 23% to $257.1 million in 2024 from$334.6 million in 2023[445]. - Product revenue increased by $130.9 million to$397.6 million, driven primarily by VYVGART, which saw an 835% increase in sales since its launch[458][460]. - ZEJULA maintained its position as the leading PARP inhibitor for ovarian cancer, with sales of $187.1 million, an 11$257.1 million, a reduction from the $334.6 million loss in 2023, resulting in a loss per ordinary share of$0.26[471]. Research and Development - Research and development expenses decreased by 12% to $234.5 million in 2024, down from$265.9 million in 2023[461]. - Research and development expenses decreased by $31.4 million (12$234.5 million, primarily due to a $26.0 million decrease in clinical program expenses[462]. - The company has multiple late-stage product candidates and ongoing pivotal trials, indicating a strong pipeline for future growth[442][446]. - The company aims to achieve profitability by the end of 2025 while continuing to invest in research and development[448]. Cash Flow and Investments - Net cash used in operating activities increased by$16.7 million in 2024, totaling $214.9 million, influenced by a decrease in net loss and adjustments to reconcile net loss[490]. - Net cash used in investing activities surged by$364.4 million in 2024, primarily due to increased purchases of short-term investments and acquisition of intangible assets[491]. - Net cash provided by financing activities was $349.9 million in 2024, a significant increase from a net cash used of$6.4 million in 2023, mainly due to proceeds from public offerings[492]. - As of December 31, 2024, the company had cash and cash equivalents of $879.7 million, expected to meet cash requirements for at least the next 12 months[486]. Expenses - Selling, general, and administrative expenses increased by$17.1 million (6%) in 2024, reaching $298.7 million, driven by higher costs associated with the launch of VYVGART and NUZYRA[464]. Interest and Currency Risks - Interest income decreased by$2.7 million in 2024, primarily due to reduced cash and cash equivalents[466]. - Interest expense increased by $2.3 million in 2024, attributed to new short-term debt incurred during the year[467]. - Foreign currency losses increased by$0.3 million in 2024, mainly due to the depreciation of the RMB against the U.S. dollar[468]. - The company is exposed to interest rate risks on its short-term debt, which amounted to $131.7 million as of December 31, 2024[507]. - A hypothetical 10$7.80 to US$1.00 since 1983, but there is no assurance this will continue[500]. - The company has not used derivative financial instruments to hedge foreign exchange risk, as it believes its exposure is limited[497]. - The conversion of RMB into foreign currencies is based on rates set by the PBOC, which can fluctuate due to political and economic conditions in Greater China[498]. Customer and Credit Risk - The company's two largest customers accounted for approximately 23% of total accounts receivable as of December 31, 2024[503]. - The company has not incurred significant credit losses historically, managing credit risk through ongoing monitoring of outstanding balances[503]. - The company manages its investment portfolio to preserve principal, provide liquidity, and maximize income without significantly increasing risk[506].