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Applied Therapeutics(APLT) - 2025 Q1 - Quarterly Results

Financial Performance - Cash and cash equivalents totaled 79.4millionasofDecember31,2024,comparedto79.4 million as of December 31, 2024, compared to 49.9 million at December 31, 2023, representing a 59% increase[9] - Research and development expenses for the year ended December 31, 2024, were 48.7million,adecreaseofapproximately1048.7 million, a decrease of approximately 10% from 53.9 million for the year ended December 31, 2023[9] - General and administrative expenses increased to 56.0millionfortheyearendedDecember31,2024,from56.0 million for the year ended December 31, 2024, from 20.6 million in 2023, marking an increase of approximately 172%[9] - The net loss for the year ended December 31, 2024, was 105.6million,or105.6 million, or 0.76 per share, compared to a net loss of 119.8million,or119.8 million, or 1.42 per share, for the year ended December 31, 2023[9] - Total revenue for the year ended December 31, 2024, was 455,000,asignificantdecreasefrom455,000, a significant decrease from 9.99 million in 2023[16] - The accumulated deficit increased to 574.2millionasofDecember31,2024,comparedto574.2 million as of December 31, 2024, compared to 468.6 million as of December 31, 2023[14] Regulatory and Strategic Developments - The company received a Complete Response Letter from the FDA regarding the New Drug Application for govorestat for Classic Galactosemia, and is evaluating its response[3] - The company is focused on preparing for potential regulatory interactions regarding govorestat in both Classic Galactosemia and SORD Deficiency[2] - The company appointed key senior executives to enhance its regulatory, medical, and quality affairs capabilities, including Todd F. Baumgartner as Chief Regulatory Officer[3] Asset Management - The total assets increased to 86.7millionasofDecember31,2024,from86.7 million as of December 31, 2024, from 54.8 million as of December 31, 2023[14]