Sales Performance - Total sales for the first quarter of 2025 reached 21,893million,a2.421,383 million in 2024[3] - U.S. sales increased by 5.9% to 12,305million,whileinternationalsalesdecreasedby1.89,588 million[1] - Innovative Medicine segment reported a 2.3% increase in sales, while MedTech segment sales grew by 2.5%[2] - Oncology sales in the U.S. surged by 26.4% to 3,013million,withinternationalsalesincreasingby9.62,103 million, reflecting a 16.4% increase compared to 1,806millioninQ12024[15]−TotalMedTechsegmentsalesreached8,020 million in Q1 2025, a 2.5% increase compared to 7,821millioninQ12024[16]−U.S.MedTechsalesgrewby5.14,213 million, while international sales slightly decreased by 0.2% to 3,807million[16]−TheVisionsegmentintheU.S.reporteda3.4566 million, while international sales remained relatively flat with a 0.4% increase[16] Profitability - Gross profit decreased by 2.3% to 14,536million,withagrossmarginof66.410,999 million, a significant increase of 237.9% from 3,255millionin2024[3]−Adjustednetearningspershare(diluted)roseto2.77, a 2.2% increase from 2.71inthepreviousyear[5]ExpensesandTaxation−Theeffectivetaxrateincreasedto19.33,225 million, representing 14.7% of sales[3] - The company initiated a restructuring program in the MedTech segment, incurring 55millioninexpensesduringthefirstquarterof2025[6]SegmentPerformance−USsalesintheImmunologysegmentdecreasedby10.52,196 million, while international sales fell by 15.8% to 1,510million[12]−TheNeurosciencesegmentreporteda8.61,647 million, with US sales down 8.1% to 968million[13]−Cardiovascular/Metabolism/OthersegmentintheUSsawasignificantincreaseof35.4855 million, while international sales decreased by 19.7%[14] - XARELTO sales in the US increased by 33.3% to 690million,contributingtoatotalof690 million worldwide[14] - US sales for STELARA decreased by 29.8% to 981million,withinternationalsalesdown38.9644 million[12] - The Pulmonary Hypertension segment reported a worldwide revenue of 1,025million,adecreaseof2.31,049 million in Q1 2024[13] - SPRAVATO sales in the US increased by 45.0% to 276million,withworldwidesalesreaching320 million, up 41.9%[12] - The company reported a 2.9% decline in US sales for Infectious Diseases, totaling 315million,whileinternationalsalesdecreasedby1.9487 million[13] Future Projections - Innovative Medicine segment sales for the full year 2024 are projected to reach 2,225million,withsignificantcontributionsfromPulmonaryHypertensionproducts[18]−RybrevantandLazcluzegenerated93 million in total sales in Q1 2024, with U.S. sales accounting for 36million[18]−Talvey′ssalesintheU.S.forQ12024were50 million, with full-year expectations of 241million[18]−OtherOncologyproductsgenerated328 million in total sales in Q1 2024, with U.S. sales at 93million[18]−ThecompanyanticipatescontinuedgrowthinthePulmonaryHypertensionsegment,withQ12024U.S.salesof356 million[18] - International sales of Infectious Diseases products reached 1,395millioninQ12024,withU.S.salesat19 million[18] - The overall operational growth for the MedTech segment was 4.1%, excluding currency effects[16]