Salarius Pharmaceuticals(SLRX) - Prospectus(update)

As filed with the Securities and Exchange Commission on August 7, 2025 Registration No. 333-284368 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 5 TO FORM S-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 SALARIUS PHARMACEUTICALS, INC. (Exact name of registrant as specified in its charter) Copies to: Andrew L. Strong, Esq. Stephen M. Nicolai, Esq. Hogan Lovells US LLP 609 Main Street, Suite 4200 Houston, TX 77002 (713) 632-1400 Jeffrey Kuras, Esq. Honigman L ...