Financial Performance - Revenues for 2023 were 42,857million,adecreaseof544,915 million in 2022[147]. - GAAP operating income for 2023 was 6,859million,down188,393 million in 2022, resulting in a GAAP operating income margin of 16.0%[147]. - Adjusted operating income (non-GAAP) decreased by 11% to 9,810millionin2023,withanadjustedoperatingincomemarginof22.90.33 billion in 2023, significantly down from 3.11billionin2022[150].−LifeSciencesSolutionssegmentrevenuesfellby269,977 million, with segment income decreasing by 39% to 3,420million[159].−AnalyticalInstrumentssegmentrevenuesincreasedby107,263 million, with segment income rising by 27% to 1,908million[160].−SpecialtyDiagnosticssegmentrevenuesdecreasedby84,405 million, while segment income increased by 10% to 1,124million[161].−LaboratoryProductsandBiopharmaServicessegmentrevenuesgrewby223,041 million, with segment income increasing by 17% to 3,358million[163].CashFlowandDebt−AsofDecember31,2023,cashandcashequivalentstotaled8,077 million, a decrease from 8,524millionin2022[172].−Totaldebtincreasedto34,917 million in 2023 from 34,488millionin2022[172].−Netcashprovidedbyoperatingactivitieswas8,406 million in 2023, down from 9,154millionin2022[175].−Freecashflowfor2023wasreportedat7,014 million, compared to 6,935millionin2022[194].−Thecompanyhasarevolvingcreditfacilityprovidingupto5,000 million, with no borrowings outstanding as of December 31, 2023[174]. Acquisitions and Stock Repurchase - The company spent 2,700millionontheacquisitionofTheBindingSiteGroupand910 million on CorEvitas, LLC in 2023[180]. - The company repurchased 3,000millionofitscommonstock(5.2millionshares)during2023[182].TaxandValuation−ThecompanyexpectsitsGAAPeffectivetaxratefor2024tobebetween40.54 billion at December 31, 2023, down from 0.57billionin2022[202].−Thecompany′staxvaluationallowanceremainedat1.32 billion as of December 31, 2023[207]. Goodwill and Intangible Assets - Goodwill and indefinite-lived intangible assets totaled 44.02billionand1.24 billion, respectively, as of December 31, 2023[198]. - The company recorded definite-lived intangible asset impairments of 0.01billionin2023[201].−Thecompanyperformedquantitativegoodwillimpairmenttestsandfoundnoimpairmentsattheendofthetenthfiscalmonthof2023[199].CurrencyandInterestRateImpact−A100basispointdecreaseininterestrateswouldincreasethefairvalueofthecompany′sdebtbyapproximately2.33 billion[210]. - A 10% depreciation in year-end 2023 functional currencies relative to the U.S. dollar would reduce shareholders' equity by approximately 1.26billion[212].−A1043 million[214]. - A 10% depreciation in non-functional currency exchange rates applied to certain cash balances would negatively impact net income by 13million[215].EarningsPerShare−Theadjusteddilutedearningspershare(EPS)for2023was21.55, down from 23.24in2022[192].−Theadjustedoperatingincomefor2023was9,810 million, with an adjusted operating income margin of 22.9%, compared to 10,985millionand24.51,300 million and $1,500 million for 2024[181].