Financial Performance - Consolidated revenue increased by 16.1% compared to 2022, with Clinical Services revenue up 18.4% and Advanced Diagnostics Services revenue up 5.5%[240] - Total net revenue for 2023 increased by 81.9million,or16.1591.6 million compared to 2022[264] - Clinical Services revenue rose by 76.9million,or18.4495.6 million in 2023, driven by increased test volume and a favorable test mix[264] - Advanced Diagnostics revenue increased by 5.0million,or5.596.0 million in 2023, primarily due to higher billings across its portfolio[265] - The net loss for the year ended December 31, 2023, was 87.968million,adecreasefromanetlossof144.250 million in 2022, representing a 39% improvement[285] - Basic and diluted net loss per share for 2023 was 0.70,comparedto1.16 in 2022, indicating a 40% reduction in loss per share[285] - Non-GAAP Adjusted EBITDA for 2023 was 3.486million,asignificantrecoveryfromalossof48.010 million in 2022[290] - The company reported a comprehensive loss of 85.743millionfor2023,comparedtoacomprehensivelossof147.511 million in 2022[325] Operational Efficiency - Net cash used in operations improved by 64.0millioncomparedto2022[240]−AdjustedEBITDAincreasedby51.5 million to a positive 3.5millioncomparedto2022[240]−Grossmarginimprovedby448basispointswhilealsoenhancingturnaroundtime[240]−Generalandadministrativeexpensesdecreasedby0.3 million in 2023, representing 41.1% of revenue compared to 47.7% in 2022[271] - Research and development expenses decreased by 3.0millionin2023,accountingfor4.63.5 million, or 5.2%, in 2023, primarily due to higher compensation and benefit costs[275] - Restructuring charges rose by 6.6million,or145.511.1 million, as part of a program to improve operational efficiency[277][279] Cash Flow and Liquidity - Cash used in operating activities decreased to 1.953millionin2023from65.993 million in 2022, reflecting a 64.040millionimprovement[291]−Cashprovidedbyinvestingactivitieswas76.707 million in 2023, a substantial increase from cash used of 0.517millionin2022[292]−Cashprovidedbyfinancingactivitiesdecreasedto4.554 million in 2023 from 11.829millionin2022,primarilyduetoareductionincashfromstockissuance[293]−AsofDecember31,2023,thecompanyhad342.488 million in cash and cash equivalents, up from 263.180millionattheendof2022[291]−Thecompanyexpectssufficientliquiditytofundoperationalneedsforatleastthenext12months,supportedbycashonhandandmarketablesecuritiestotaling415.2 million[294] Investments and Growth Strategy - The company aims to expand its test offerings, including advanced NGS tools such as WES and WGS, to drive growth in Advanced Diagnostics[237] - The acquisition of Inivata provided oncology liquid biopsy technology capabilities, enhancing the company's testing services[247] - The Advanced Diagnostics segment supports pharmaceutical firms throughout the drug development process, from discovery to commercialization[248] - The company is committed to leveraging informatics and data-related tools to address real-world problems in oncology[238] - The company plans to invest in information technology and automation to reduce testing costs and improve value[239] - The company remains optimistic about growth opportunities in key markets despite potential inflationary pressures in 2024[299] Marketable Securities and Fair Value - As of December 31, 2023, the total fair value of marketable securities was 72,715,000,downfrom174,809,000 as of December 31, 2022[394][395] - The Company reported a total of 55,485,000inmarketablesecuritieswithamaturityofoneyearorlessasofDecember31,2023[396]−TheCompany’sLevel1financialassetstotaled370,820,000 as of December 31, 2023[397] - The total gross unrealized losses for marketable securities as of December 31, 2023, were 1,486,000[394]DebtandFinancing−Thecompanyrecordedtotallong−termdebt,net,of538,198 thousand as of December 31, 2023, slightly increasing from 535,322thousandin2022[406]−Theestimatedfairvalueofthe0.25262.4 million as of December 31, 2023, up from 218.2millionin2022[406]−TheCompanycompletedthesaleof201.3 million of 2025 Convertible Senior Notes with a stated interest rate of 1.25% and a maturity date of May 1, 2025, resulting in net proceeds of approximately 194.5millionafterdiscountsandexpenses[419]−Thetotallong−termdebtasofDecember31,2023,amountsto546.25 million, with 345millionrelatedtothe2028ConvertibleNotesand201.25 million related to the 2025 Convertible Notes[429]