Revenue Performance - Q4 2023 revenue was 155.7million,adecreasefrom186.8 million in Q4 2022, while full-year 2023 revenue was 638.8million,downfrom801.5 million in 2022[8] - Total revenue for Q4 2023 decreased by 17% to 155.7millioncomparedto186.8 million in Q4 2022, and full-year revenue declined by 20% to 638.8millionfrom801.5 million in 2022[23] - Organic revenue growth (Non-GAAP) for Q4 2023 was -21%, reflecting a decline in base revenue excluding COVID-related and inorganic M&A impacts[25][26] - COVID-related revenue declined by 66% in Q4 2023 to 8.0millionfrom23.8 million in Q4 2022, and by 77% for the full year to 32.2millionfrom141.1 million in 2022[26] Profitability Metrics - Q4 2023 gross profit (GAAP) was 67.6million,comparedto96.1 million in Q4 2022, with adjusted gross profit (non-GAAP) at 76.5million[8]−Full−year2023netincome(GAAP)was41.6 million, down from 186.0millionin2022,withadjustednetincome(non−GAAP)at98.4 million[8] - Q4 2023 loss per share (GAAP) was (0.46),comparedtoearningsof0.85 in Q4 2022, with adjusted earnings per share (non-GAAP) at 0.33[8]−AdjustedEBITDA(Non−GAAP)forQ42023was26.2 million, down from 49.1millioninQ42022,whilefull−yearAdjustedEBITDAwas128.0 million compared to 246.9millionin2022[31]−NetlossforQ42023was25.5 million, compared to a net income of 48.7millioninQ42022,withfull−yearnetincomedroppingto41.6 million from 186.0millionin2022[23]−Adjustednetincome(Non−GAAP)forQ42023was18.8 million, down from 39.1millioninQ42022,whilefull−yearadjustednetincomewas98.4 million compared to 188.6millionin2022[28]−Adjustedearningspershare(Non−GAAP)forQ42023was0.33, down from 0.68inQ42022,whilefull−yearadjustedEPSwas1.75 compared to 3.28in2022[29]CashandInvestments−Cash,cashequivalents,andshort−terminvestmentsatDecember31,2023,were751.3 million, up from 623.8millionattheendof2022[11]−Cash,cashequivalents,andmarketablesecuritiesincreasedto751.3 million as of December 31, 2023, up from 623.8millionattheendof2022[24]Long−termObligations−Long−termobligationsrosesignificantlyto695.0 million as of December 31, 2023, compared to 209.8millionattheendof2022[24]GuidanceandForecasts−FY2024revenueguidanceis620M - 650M,withayear−over−yearchangeof(326.000 billion to 30.000billion[35]−AdjustedNetIncome(Non−GAAP)guidancefor2024isprojectedbetween80.000 billion and 84.000billion[35]−GAAPEarningsPerShare(Diluted)guidancefor2024isbetween0.46 and 0.53[36]−AdjustedEarningsPerShare(Non−GAAP)guidancefor2024isexpectedtobeintherangeof1.42 to 1.49[36]ProductLaunchesandAcquisitions−ThecompanylaunchedTangenXR◯SC,theindustry′sfirstholder−free,self−containedTangentialFlowFiltration(TFF)device[6]−TheacquisitionofMetenovaABcontributed5 million in revenue in Q4 2023, meeting expectations[6] Restructuring and Costs - Restructuring costs impacted Q4 2023 results with 8.2millioninadjustments,contributingtoatotalof32.2 million for the full year[27][28] - Restructuring activities in Q4 2023 included inventory adjustments and manufacturing facility consolidation, with costs related to severance and employee-related expenses[39] R&D and SG&A Expenses - GAAP R&D Expense for Q4 2023 was 10.285billion,adecreaseof7.511.113 billion in Q4 2022[33] - Adjusted R&D Expense (Non-GAAP) for Q4 2023 was 10.202billion,down7.411.021 billion in Q4 2022[33] - GAAP SG&A Expense for Q4 2023 increased to 57.512billion,up853.237 billion in Q4 2022[34] - Adjusted SG&A Expense (Non-GAAP) for Q4 2023 was 47.504billion,an8.143.947 billion in Q4 2022[34] Other Financial Items - Foreign currency gains on intercompany loans in Q4 2023 amounted to $7.743 billion, recorded under Other income (expenses), net[39] Order Strength - Q4 2023 book-to-bill ratio was 1.03, indicating continued order strength[5]