Financial Performance - Orthofix's Global Spine segment accounted for 84% of total net sales in 2025, while Global Limb Reconstruction contributed 16%[26]. - The company completed a merger with SeaSpine Holdings Corporation in January 2023, converting each share of SeaSpine common stock into 0.4163 shares of Orthofix common stock[24]. - The company operates in two reporting segments: Global Spine (84% of total net sales) and Global Limb Reconstruction (16% of total net sales) for the year 2025[115]. - In 2025, 2024, and 2023, the company incurred research and development expenses of $65.8 million, $73.6 million, and $80.2 million, respectively[84]. Product Portfolio - The Global Spine segment includes Bone Growth Therapies and Spinal Implants, with significant growth initiatives focused on innovation and partnerships[30]. - Orthofix's Bone Growth Therapies include market-leading devices utilizing PEMF and LIPUS technologies, primarily sold in the U.S.[31]. - The company offers a comprehensive portfolio of spinal implants designed for various surgical procedures, including ALIF, PLIF, and ACDF[36]. - The company’s interbody portfolio includes various material types and integrated fixation options, catering to different surgical approaches and patient needs[50]. - The company’s comprehensive spinal fixation solutions cover the entire spine, offering modular options for various surgical needs[51]. - The company’s biologics portfolio includes bone graft substitutes and is distributed globally through a network of distributors and sales representatives[35]. - The company’s Biologics products are derived from human or bovine tissue, sourced from FDA-registered tissue banks, ensuring safety and compliance[132]. - The company offers a 3D printed Firebird SI system for sacroiliac joint disruptions, differentiating itself from competitors who lack SI fixation options[38]. - Trinity Elite and Virtuos Lyograft are leading products in the cellular allografts portfolio, with Trinity Elite maintaining market leadership for over a decade[58]. Technology and Innovation - The 7D FLASH Navigation System is a key enabling technology that enhances image-guided surgery, providing significant economic value and improved safety[34]. - The 7D FLASH Navigation System utilizes visible light technology for fast, efficient, and radiation-free spine surgery, enhancing surgical workflow[53]. - The 7D FLASH Navigation System's Spine Module will see enhancements and new features launched in 2026, including additional navigation tools and improved user interface[54]. - The STIM onTrack mobile app allows physicians to remotely monitor patient adherence to treatment protocols, enhancing patient engagement and outcomes[44][47]. - The company is exploring opportunities to integrate the 7D FLASH Navigation technology into various orthopedic applications[82]. Market Strategy - The company emphasizes ongoing clinical research to support its product portfolios and aims to attract and retain key talent for growth[33]. - Orthofix's strategy includes regular product launches and global sales channel optimization to enhance market presence[33]. - The company aims to continue the strong pace of new product launches and invest in technologies to support market opportunities[71]. - The company plans to continue investing in additional instrument sets and marketing efforts to support the expansion of its independent sales agent footprint[120]. - The company focuses on enhancing its competitive position through product features, value-added services, and training, rather than competing solely on price[128]. Regulatory Compliance - The company’s Spinal Implants and Global Limb Reconstruction products are primarily classified as Class II devices, while Bone Growth Therapies products are classified as Class III and approved through the PMA process[89]. - The company incurs significant costs to maintain compliance with the E.U. Medical Device Regulation, which imposes strict requirements for marketing and selling medical devices, with transition periods extending until December 2028 for certain products[90]. - The company’s products derived from human tissue must comply with both HCT/P requirements and additional regulations applicable to biologics, devices, or drugs, including 510(k) clearance or PMA approval[96]. - The company is AATB-accredited and licensed for tissue banking in multiple states, ensuring compliance with various state regulations[98]. - The company is subject to various U.S. laws regulating healthcare fraud and abuse, including the Anti-Kickback Statute and the Stark Law, which impact sales and marketing practices[106]. Competition and Market Challenges - The company’s Bone Growth Therapies product category competes with products from companies like EBI, Enovis, and Bioventus, while its Biologics and Spinal Implants markets face competition from major players like Medtronic and DePuy Synthes[127]. - The healthcare industry consolidation has led to increased pricing pressures, with Group Purchasing Organizations (GPOs) negotiating discounts that could adversely affect profitability[147]. - The company faces competition from larger device companies that leverage volume discounts and multi-year arrangements, potentially limiting access to key customers[149]. - The medical device industry is characterized by rapid technological change, with new products regularly introduced that may render existing products non-competitive[151]. - Supply chain disruptions, such as those experienced during the COVID-19 pandemic, have previously impacted operations and could affect future business results[152]. Operational Risks - The company relies on a limited number of suppliers, and interruptions in the supply chain could lead to significant delays and additional costs[153]. - The supply of allograft tissues is unpredictable, and any reclassification by the FDA could increase operational costs and regulatory burdens[157]. - The approval process for human-derived products in the E.U. is lengthy and unpredictable, with non-compliance potentially leading to product bans[159]. - The company faces significant risks in developing and introducing new products, which may not meet market expectations[161]. - Cyber-attacks and data breaches pose risks to the company's information systems, potentially leading to unauthorized access to sensitive data and significant operational disruptions[182]. Human Resources and Talent Management - Attracting and retaining qualified executives and key employees is crucial for the company, as competition for talent in the medical device industry is intense[201]. - The company relies on third parties for clinical studies and pre-clinical development, and any failure in their performance could delay regulatory approvals and commercialization[156]. Community Engagement - The company emphasizes community involvement through its "Orthofix Gives Back" initiative, focusing on health innovation and education to create a lasting impact[144].

– ARV-102 (LRRK2) Phase 1 clinical data in patients with Parkinson's disease accepted for oral presentation at AP/PD Conference in March 2026 – – Clinical data from ARV-806 (KRAS G12D) and ARV-393 (BCL6) on track for presentations in 2026 – – Phase 1 trial in healthy volunteers initiated with polyQ-AR degrader ARV-027; first immuno- oncology PROTAC HPK1 degrader, ARV-6723, on track to initiate Phase 1 trial in mid-2026 – – Randy Teel, Ph.D., appointed President, Chief Executive Officer, and Director – – Com ...

Investor Contact: Scott Galovan Avanos Medical, Inc. 470-562-2692 Investor.Relations@Avanos.com Media Contact: Katrine Kubis Avanos Medical, Inc. CorporateCommunications@Avanos.com Avanos Medical, Inc. Announces Fourth Quarter and Full-Year 2025 Results ALPHARETTA, Ga., February 24, 2026/PRNewswire/ -- Avanos Medical, Inc. (NYSE: AVNS) today reported fourth quarter and full-year 2025 results. "I'm very pleased with our fourth quarter and full-year results, which demonstrate meaningful progress on our strate ...

Exhibit 99.1 DigitalOcean Announces Fourth Quarter and Fiscal Year 2025 Financial Results BROOMFIELD, Colo., February 24, 2026 – DigitalOcean Holdings, Inc. (NYSE: DOCN), the agentic inference cloud, today announced results for its fourth quarter and fiscal year ended December 31, 2025. "AI is reshaping entire industries, and we are built for this shift. DigitalOcean's Agentic Inference Cloud is gaining further traction with large Cloud and AI Native customers that are driving the shift, which is evident in ...

Exhibit 99.1 News Release Orthofix Reports Fourth Quarter and Full-Year 2025 Financial Results and Provides 2026 Financial Guidance LEWISVILLE, Texas — February 24, 2026 — Orthofix Medical Inc. (NASDAQ:OFIX), a leading global medical technology company, today reported its financial results for the fourth quarter and full-year ended December 31, 2025, provided full- year 2026 financial guidance and updated its three-year financial targets. All pro forma measures contained within this release exclude the impa ...

EXHIBIT 99.1 Keurig Dr Pepper Reports Q4 and Full Year 2025 Results and Provides 2026 Outlook Delivers 2025 Results Consistent with Guidance Performance Led by Strong Momentum in U.S. Refreshment Beverages Targets Double-Digit Adjusted EPS Growth in 2026, Including Anticipated JDE Peet's Contribution Role of Board Chair to Transition from Bob Gamgort to Pamela Patsley BURLINGTON, MA and FRISCO, TX (February 24, 2026) – Keurig Dr Pepper Inc. (NASDAQ: KDP) today reported results for the fourth quarter and ful ...

Employee Statistics - As of December 31, 2025, the company had approximately 3,800 employees, with a voluntary turnover rate of 8% for non-production employees and 12% for production employees[58]. - As of December 31, 2025, approximately 54% of the company's production employees in the U.S. were represented by labor unions[59]. Financial Liabilities and Interest Rates - The company reported liabilities for environmental matters of $4.1 million as of December 31, 2025, down from $4.6 million in 2024[67]. - The company has interest rate swaps outstanding with notional amounts totaling $325 million as of December 31, 2025, aimed at minimizing earnings fluctuations due to interest rate volatility[247]. - A hypothetical increase of 0.25% in SOFR interest rates would increase the company's 2026 interest expense by approximately $0.3 million[246]. - The average interest rate for variable rate principal payments scheduled for 2026 is 4.61%, with total variable rate principal payments amounting to $410.6 million[249]. Sustainability Initiatives - The company is committed to sustainability, focusing on reducing its carbon footprint and improving product circularity, which aligns with its growth strategy[53]. - The company has developed a mineral fiber ceilings recycling program to divert reclaimed ceiling tiles from landfills, anticipating increased demand for sustainable products[53]. Research and Development - The company engages in research and development activities to enhance product competitiveness and manufacturing processes[63]. Employee Health and Safety - The company maintains a focus on employee health and safety, aiming to eliminate workplace injuries and promote a culture of safety[60].

Membership and Revenue Growth - As of December 31, 2025, Life Time had nearly 1.6 million individual members and approximately 873,000 memberships[19] - Membership dues and enrollment fees represented over 72% of total Center revenue for the year ended December 31, 2025, up from over 70% previously[24] - Average revenue per center membership increased to $3,531 in 2025, compared to $3,160 in 2024 and $2,810 in 2023[44] - Total memberships increased to 872,936 in 2025, up from 866,085 in 2024, and 814,936 in 2023, representing a growth of 0.2% year-over-year[201] - Membership dues and enrollment fees revenue reached $2,111,370 in 2025, a 13.9% increase from $1,853,963 in 2024 and a 35.5% increase from $1,557,289 in 2023[201] - Total Center revenue increased to $2,909 million for the year ended December 31, 2025, up from $2,547 million in 2024 and $2,154 million in 2023, indicating a growth of approximately 14.2% year-over-year[174] - Center revenue includes membership dues, enrollment fees, and in-center revenue, which encompasses various member services and product sales[181] - In-center revenue increased by $104.7 million, accounting for 28.9% of the center revenue growth, reflecting higher member utilization of offerings, particularly Dynamic Personal Training[218] Expansion and Growth Strategy - Life Time plans to open 12 to 14 new locations annually starting in 2026, focusing on affluent metropolitan areas[34] - The company opened 10 new centers in 2025, bringing the total number of centers to 189, up from 179 in 2024 and 171 in 2023[201] - The company has 17 new centers under construction and operates 10 satellite locations, indicating ongoing expansion efforts[153] - Approximately 71% of Life Time's centers are now leased, with 84% of new centers opened since 2015 being leased[38] - The company is executing an asset-light growth strategy, expecting to lease the majority of new centers in the future[104] - The company aims to expand in wealthier demographic and coastal locations, but higher construction costs and competition for sites may impact profitability[79] Member Engagement and Services - The company organized approximately 51,800 events in 2025, serving as a social and community hub for members[31] - Dynamic Personal Training sessions averaged over 220,000 per month in 2025, an 18% increase from 2024, while Dynamic Stretch sessions reached over 20,000 per month, a 34% increase[46] - Small Group Training sessions averaged over 42,000 per month in 2025, a 6% increase from 2024, with increased participation rates[46] - The ARORA community for members aged 55 and older averaged over 9,000 classes per month in 2025, a 9% increase from 2024[46] - Enhanced offerings include broader sales of LTH nutritional products on e-commerce platforms and a digital platform providing an omni-channel experience, including live streaming fitness classes and personalized AI-driven health recommendations[177] Financial Performance and Metrics - Adjusted net income for 2025 was $325,522, a significant increase from $200,451 in 2024 and $129,704 in 2023[202] - Adjusted EBITDA for 2025 was $825,175, reflecting a 22% increase from $676,780 in 2024 and a 54% increase from $536,831 in 2023[206] - Net income for the year ended December 31, 2025, was $373.671 million, up from $156.240 million in 2024, reflecting a net income margin increase from 6.0% to 12.4%[217] - Free cash flow for 2025 was $206,466, a decrease from $273,580 in 2024 but an improvement from a negative $108,989 in 2023[207] - Operating expenses totaled $2,513.962 million for the year ended December 31, 2025, representing 84.0% of total revenue, a decrease from 86.3% in 2024[217] Risks and Challenges - The company faces risks in attracting and retaining members, which could negatively impact business operations and financial condition[70] - The macroeconomic environment, including inflation and interest rates, has increased operational costs and affected capital expenditures, leading to a slowdown in new center construction[74] - New center openings in existing markets may cannibalize memberships from other centers, potentially diminishing overall revenue[80] - The company may incur significant costs in developing new business strategies, with no guarantee of success[83] - Competition in the health, fitness, and wellness industry poses risks to market share and revenue optimization[87] - Dependence on third-party suppliers for equipment and services could disrupt operations and adversely affect financial condition[88] Debt and Financial Obligations - As of December 31, 2025, the company had total consolidated indebtedness of approximately $1,525 million, with an interest expense of $82 million for the year ended December 31, 2025[103] - The annual debt service obligation for 2026 is expected to be approximately $86 million for interest and $22 million for principal payments[103] - The company may face increased costs and reduced cash flows available for working capital due to substantial debt service and lease obligations[107] - The credit agreement governing the senior secured credit facility includes covenants that may restrict the company's ability to operate and take advantage of business opportunities[105] Technology and Cybersecurity - The company is investing in technology, including a generative AI-driven personal companion, to enhance member experiences and maintain competitiveness[95] - The cybersecurity program is designed in accordance with the NIST framework, focusing on various material risks including operational and compliance-related risks[138] - The company has established an incident response plan to manage cybersecurity incidents, including identification, containment, and remediation[142] Corporate Governance and Shareholder Matters - As of December 31, 2025, the Voting Group held approximately 38.3% of the voting power of the company's common stock, down from 62.7% as of December 31, 2024[124] - The board of directors authorized a share repurchase program for up to $500 million of common stock, which may be modified or suspended at any time[132] - Future sales of common stock by the Voting Group or the perception of such sales could lead to a decline in the market price of the company's common stock[125]

Table of Contents UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K (Mark One) ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 OR DELAWARE 27-1537290 (I.R.S. Employer Identification No.) Registrant's telephone number, including area code: (617) 977-5700 Securities registered pursuant to Section 12(b) of the Act: ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT ...

CONSTELLATION REPORTS FOURTH QUARTER AND FULL YEAR 2025 RESULTS Earnings Release Highlights Baltimore (Feb. 24, 2026) — Constellation Energy Corporation (Nasdaq: CEG) today reported its financial results for the fourth quarter and full year 2025. "Constellation enters 2026 well positioned to meet the nation's growing demand for reliable, clean electricity. This past year, we welcomed Calpine to our company – expanding our generation portfolio, strengthening our commercial platform and enhancing our ability ...