Financial Performance - The company's revenue for the year ended December 31, 2024, increased by 9.6% year-on-year to RMB 18,675.4 million, with non-COVID revenue growing by 13.1%[7] - Gross profit rose by 12.1% to RMB 7,650.8 million, resulting in a gross margin of 41.0%[3] - Net profit increased by 10.5% to RMB 3,945.4 million, with a net profit margin of 21.1%[3] - Revenue for the year ended December 31, 2024, was RMB 18,675,371 thousand, an increase of 9.66% from RMB 17,034,255 thousand in 2023[125] - The net profit for the year was RMB 3,945,371 thousand, compared to RMB 3,570,624 thousand in 2023, representing a growth of 10.45%[126] - The adjusted net profit for the year ended December 31, 2024, was RMB 5,396.9 million, up from RMB 4,950.4 million in 2023, reflecting a growth of approximately 9.0%[101] - The adjusted EBITDA for 2024 was RMB 7,999.3 million, compared to RMB 6,993.0 million in 2023, representing a growth of approximately 14.4%[103] Revenue Breakdown - Revenue from North America rose significantly to RMB 10,695.8 million, accounting for 57.3% of total revenue, compared to RMB 8,073.5 million or 47.4% in the previous year[50] - IND pre-service revenue grew by 30.7% to approximately RMB 7,062.2 million, representing 37.8% of total revenue for the year ending December 31, 2024[51] - Revenue from the XDC segment increased to RMB 3,944.0 million, representing 21.1% of total revenue, compared to RMB 1,906.1 million or 11.2% in the previous year[54] - CRDMO services contributed RMB 18,362,739,000 to total revenue in 2024, up from RMB 16,749,791,000 in 2023, reflecting a growth of 9.66%[137] Operational Highlights - The number of ongoing integrated projects reached 817, with 151 new projects added during the reporting period[4] - The company secured 20 external projects through its "Winning Molecules" strategy, including 13 late-stage clinical and commercial production projects[4] - The total value of uncompleted orders as of December 31, 2024, reached USD 18.5 billion, including USD 10.5 billion in service orders and USD 8 billion in potential milestone payments[7] - The company has empowered over 600 IND submissions, with a recent autoimmune disease project completed in just six months, significantly optimizing the development cycle from DNA to IND to nine months[17] - The WuXiaTM platform has delivered over 1,000 cell lines, enabling 150 comprehensive CMC projects annually, making it one of the largest platforms in the industry[18] Strategic Partnerships and Collaborations - The company has established partnerships with the top 20 global pharmaceutical companies and most large pharmaceutical companies in China, expanding its customer base[8] - The company has established strategic collaborations with GSK, Candid Therapeutics, BioNTech, and Medigene to advance new biopharmaceutical technologies, enhancing client trust and driving innovation in biotherapy[16] - The company has established a strategic partnership with Merck for the development of the B cell depletion therapy CN201, showcasing the unique advantages of its CRDMO platform[29] Production and Capacity Expansion - The company has expanded its production services significantly, with 66 late-stage clinical and 21 non-COVID commercialization projects as of the reporting period end[32] - The company has enhanced its production capacity, increasing the total capacity at its Hangzhou facility to 23,000 liters and completing mechanical work at its Suzhou facility, which is expected to reach GMP readiness soon[39] - The company has achieved GMP certification for all three production facilities in Ireland, successfully completing multiple 16,000-liter scale PPQ productions during the reporting period[35] Financial Management and Expenses - Sales and marketing expenses increased by 61.1% from approximately RMB 294.0 million for the year ended December 31, 2023, to approximately RMB 473.6 million for the year ended December 31, 2024, with the percentage of sales and marketing expenses to revenue rising from 1.7% to 2.5%[62] - Administrative expenses grew by 11.9% from approximately RMB 1,495.4 million for the year ended December 31, 2023, to approximately RMB 1,673.5 million for the year ended December 31, 2024, driven by increased employee-related costs and support for global business expansion[63] - Research and development expenses decreased by 2.5% from approximately RMB 785.8 million for the year ended December 31, 2023, to approximately RMB 766.4 million for the year ended December 31, 2024, due to automation and enhanced operational efficiency[64] Shareholder Returns and Dividends - The board of directors did not recommend any final dividend for the year ended December 31, 2024[3] - The company did not declare any dividends for the year ending December 31, 2024, consistent with 2023[12] Sustainability and ESG Initiatives - The company has joined the Science Based Targets initiative (SBTi) and the UN Global Compact, focusing on ESG performance and sustainable practices[38] - The company has received multiple awards for its quality services and commitment to ESG practices, including recognition in the Dow Jones Sustainability Index and MSCI ESG ratings[43] - The company has implemented over 260 improvement projects through its WBS system, achieving increased efficiency, cost savings, and significant contributions to sustainability goals[42] Market Outlook - The global biopharmaceutical market is expected to grow at a double-digit rate in the coming years, driven by the increasing demand for biopharmaceuticals and advancements in biotechnologies such as bispecific antibodies and ADCs[46] - The company anticipates continued growth in demand for outsourcing services from biopharmaceutical and biotechnology companies, aimed at accelerating discovery, development, and production processes[46]
药明生物(02269) - 2024 - 年度业绩