Mabwell(SH:688062)2025-10-30 08:20Financial Performance - The company's revenue for Q3 2025 reached ¥464,672,799, representing a significant increase of 1,717.41% compared to the same period last year[2]. - Year-to-date revenue until the report date totaled ¥565,838,248, marking a 301.03% increase year-over-year[2]. - The total profit for the period was a loss of ¥30,501,808.77, with a year-to-date loss of ¥582,677,606.59[2]. - The net profit attributable to shareholders for the quarter was a loss of ¥46,341,079.99, and a year-to-date loss of ¥597,660,144.75[2]. - Total operating revenue for the first three quarters of 2025 reached ¥565,838,248.14, a significant increase from ¥141,095,928.06 in the same period of 2024, representing a growth of approximately 301.5%[30]. - The net loss for the first three quarters of 2025 was ¥599,596,769.92, slightly improved from a net loss of ¥696,015,164.94 in the same period of 2024[31]. - The net profit attributable to the parent company for the current period is -597,660,144.75 RMB, compared to -694,090,343.42 RMB in the previous period, showing an improvement[32]. - The total comprehensive income for the current period is -599,594,105.76 RMB, compared to -697,030,853.80 RMB in the previous period, indicating a reduction in losses[32]. Research and Development - Research and development expenses for the quarter amounted to ¥320,063,326.41, an increase of 101.45% year-over-year, accounting for 68.88% of revenue[3]. - Research and development expenses for the first three quarters of 2025 totaled ¥712,154,824.51, up from ¥481,008,266.28 in 2024, reflecting a year-over-year increase of approximately 48.0%[31]. - The company is advancing its differentiated innovation research and development, achieving significant results in its pipeline[13]. - The company has 14 core products in various stages, including 10 innovative drugs and 4 biosimilars, focusing on oncology and age-related diseases[13]. Clinical Trials and Product Development - As of the report date, 9MW2821 has enrolled over 1,600 patients in clinical trials, with three ongoing Phase III trials for various cancers[14]. - The company completed the first patient dosing for 9MW2821 in a clinical trial for ADC-treated triple-negative breast cancer in August 2025[13]. - The company observed positive efficacy signals for both 9MW2821 and JS207 in triple-negative breast cancer patients, indicating potential new treatment options[13]. - The company has one product in the marketing approval review stage and two products in Phase III critical registration clinical trials[13]. - The company’s innovative drug pipeline includes therapies for urinary tract cancer, cervical cancer, triple-negative breast cancer, and esophageal cancer[14]. - The company is focusing on expanding its market presence through innovative product development and clinical trials[13]. - The company is advancing the clinical II phase study of its innovative drug 9MW1911, a humanized anti-ST2 monoclonal antibody for chronic obstructive pulmonary disease (COPD), with the first dosing expected by July 2025 and a target of at least 120 subjects for interim analysis[15]. - The company’s 9MW3011, a targeted TMPRSS6 monoclonal antibody for polycythemia vera (PV), has achieved a milestone with the first dosing in the II phase clinical study in the U.S. scheduled for September 2025[16]. - The company’s 9MW3811, a humanized anti-IL-11 monoclonal antibody, has shown good safety and a half-life exceeding one month in I phase trials, with plans to initiate a II phase trial for pathological scars by the end of 2025[17]. - The company’s 7MW4911, an anti-CDH17 antibody-drug conjugate, received FDA clinical trial approval in August 2025 for advanced colorectal cancer and other gastrointestinal tumors[18]. Strategic Partnerships and Agreements - The company has entered into a strategic licensing agreement with Kalexo Bio, Inc. for the 2MW7141 project, potentially worth up to $1 billion in milestone payments and royalties, including an upfront payment of $12 million[21]. - The company has signed commercialization agreements for its biosimilar drugs 9MW0311 and 9MW0321 with UNILAB, INC. in the Philippines, marking a significant step in its global expansion strategy[22]. Financial Position and Cash Flow - Total assets as of the end of the reporting period were ¥4,527,089,263.10, reflecting a 5.88% increase from the end of the previous year[3]. - Cash and cash equivalents as of September 30, 2025, were ¥1,441,846,861.37, an increase from ¥1,192,626,723.55 at the end of 2024, representing a growth of about 20.9%[25]. - The total assets of the company as of September 30, 2025, were ¥4,527,089,263.10, compared to ¥4,275,508,853.05 at the end of 2024, showing an increase of approximately 5.9%[26]. - Current liabilities increased to ¥2,158,018,752.66 as of September 30, 2025, from ¥1,541,715,656.18 at the end of 2024, marking a rise of about 40.0%[26]. - Long-term borrowings decreased to ¥948,763,657.80 as of September 30, 2025, down from ¥1,006,446,352.48 at the end of 2024, indicating a reduction of approximately 5.7%[26]. - The company's total equity as of September 30, 2025, was ¥945,582,468.34, a decrease from ¥1,555,778,048.33 at the end of 2024, reflecting a decline of about 39.2%[26]. - The company reported a significant increase in accounts receivable, which rose to ¥57,294,132.08 as of September 30, 2025, compared to ¥38,343,632.47 at the end of 2024, representing an increase of approximately 49.5%[25]. - Cash inflow from operating activities for the first three quarters of 2025 is 862,766,573.45 RMB, significantly up from 299,141,739.35 RMB in the same period of 2024[34]. - The net cash flow from operating activities is -103,031,469.59 RMB, an improvement from -668,220,791.06 RMB year-over-year[34]. - Cash outflow for investment activities is 383,466,693.34 RMB, down from 525,231,877.39 RMB in the previous year, reflecting a decrease in investment spending[35]. - The net cash flow from financing activities is 517,247,450.36 RMB, compared to 827,134,397.42 RMB in the previous period, indicating a decline in financing inflows[35]. - The ending cash and cash equivalents balance is 1,439,429,197.30 RMB, down from 1,598,440,866.22 RMB in the previous year[35]. - The company received 200,000,000.00 RMB from minority shareholders as part of investment inflows[35]. Shareholder Information - The basic and diluted earnings per share for the quarter were both -¥0.12, reflecting a significant decrease in net losses compared to the previous year[2]. - The basic and diluted earnings per share for the current period are both -1.50 RMB, an improvement from -1.74 RMB in the previous period[32]. - As of September 30, 2025, the company has repurchased 202,138 shares, accounting for 0.05% of its total share capital, with a total expenditure of approximately RMB 10.69 million[23].