Caribou Biosciences(CRBU) - 2023 Q4 - Annual Report

• Bridging therapy often required. Long wait times between the initial collection of the patient's T cells and the return of the manufactured cells back to the patient may require bridging therapy, an additional line of therapy. • Manufacturing constraints. At present, there are a limited number of CAR-T cell centers and there are often insufficient manufacturing slots available to meet patient demand for autologous therapies. In addition, autologous cell manufacturing is complex and lengthy, and there can ...