Absence of Black Box Warning For Bristol Myers' Schizophrenia Treatment Could Enhance Alzheimer's Psychosis Potential

Group 1 - The FDA approved Bristol Myers Squibb's Cobenfy (xanomeline and trospium chloride) for treating schizophrenia in adults, which is a significant positive for the company's shares due to the absence of a boxed warning [1] - BMO Capital projects peak sales of $2.4 billion for Cobenfy in schizophrenia and$3.9 billion in Alzheimer's related-psychosis, raising the price target to $53 from$48 [1] - Cobenfy will be priced at $1,850 for a 30-day supply, representing a discount to previous expectations [1] Group 2 - Truist Securities highlights AbbVie Inc's emraclidine as a competing treatment for schizophrenia and Alzheimer's disease-related psychosis, but notes that Cobenfy has a first-mover advantage [2] - William Blair projects peak U.S. sales for Cobenfy to reach approximately$2 billion by 2030, driven solely by its use in treating schizophrenia [2] - If Cobenfy is approved for additional indications, annual sales could rise to around $3 billion to$5 billion, pending positive results from ongoing Phase 3 trials [2] Group 3 - The label for Cobenfy includes caution for urinary retention, elevated heart rate, reduced gastric motility, and angioedema, despite lacking a black box warning [3] - BMY stock increased by 2.33% to $51.29 following the FDA approval [3]