Crude Oil Gains Over 3%; Scholar Rock Shares Spike Higher

Market Overview - U.S. stocks traded lower with the Dow Jones index falling more than 200 points, down 0.49% to 42,146.78, NASDAQ down 0.36% to 18,073.37, and S&P 500 down 0.32% to 5,732.84 [1] - Energy shares increased by 0.5%, while consumer discretionary shares decreased by 1.3% [1] Company News - AstraZeneca entered an exclusive license agreement with CSPC Pharmaceutical Group to develop a novel small-molecule Lp(a) disruptor for dyslipidemia patients [2] - Scholar Rock Holding Corporation's shares surged 310% to $30.44 after positive Phase 3 SAPPHIRE trial results for apitegromab in SMA patients [2] - Arcadium Lithium PLC shares rose 41% to $4.34 following acquisition interest from Rio Tinto [2] - Duckhorn Portfolio Inc shares increased by 102% to $10.88 after better-than-expected Q4 results and an acquisition agreement with Butterfly Equity [2] Declining Stocks - Trevena, Inc. shares dropped 48% to $2.4192 due to a Nasdaq delisting notification [3] - Heritage Insurance Holdings, Inc. shares fell 21% to $9.65 [3] - Universal Insurance Holdings, Inc. shares decreased 18% to $17.12 [3] Commodities - Oil prices increased by 3.4% to $76.99, while gold prices decreased by 0.2% to $2,662.50 [4] - Silver fell 1.1% to $32.025, and copper decreased by 0.5% to $4.5535 [4] Economic Indicators - Eurozone retail sales rose 0.2% month-over-month in August, while the Halifax House Price Index in the UK increased by 4.7% year-over-year in September [5] - Germany's factory orders declined by 5.8% month-over-month in August [5] Asia Pacific Markets - Asian markets closed mixed with Japan's Nikkei 225 gaining 1.80% and Hong Kong's Hang Seng Index gaining 1.60%, while India's BSE Sensex dipped 0.78% [6] Foreign Exchange Reserves - Singapore's foreign exchange reserves fell to SGD 499.7 billion in September from SGD 501.3 billion [7] - Japan's leading economic indicators index fell to 106.7 in August, and the coincident economic indicators index declined to 113.5 [7]