
Core Viewpoint - Nexalin Technology, Inc. has announced positive results from a clinical trial using its Deep Intracranial Frequency Stimulation (DIFS) technology, showing improvements in memory and cognitive function for patients with mild Alzheimer's disease [1][4]. Group 1: Clinical Trial Results - The clinical trial enrolled 46 patients, with 23 receiving DIFS treatment, resulting in significant improvements in cognitive markers, including Mini-Mental State Examination (MMSE) scores (p = 0.041) and Montreal Cognitive Assessment (MoCA) scores (p = 0.025) [2][3]. - Functional MRI (fMRI) scans indicated increased local neural activity and blood flow in the hippocampus, a critical area for memory processing, suggesting that DIFS may positively influence brain function [2][3]. Group 2: Treatment Efficacy and Tolerability - The DIFS group exhibited statistically significant improvement in memory, as measured by the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), compared to the sham group [3]. - The treatment was well-tolerated, with only minor side effects such as mild tingling during stimulation sessions, which resolved quickly [3]. Group 3: Company Insights and Future Plans - Dr. David Owens, Chief Medical Officer, emphasized the milestone nature of the study and the potential of non-invasive brain stimulation to transform Alzheimer's treatment [4]. - The CEO, Mark White, highlighted the promise of DIFS as a drug-free alternative or in combination with existing treatments, and mentioned plans for a robust clinical trial utilizing different waveform frequencies to enhance clinical response [4]. Group 4: Company Background - Nexalin Technology, Inc. designs and develops innovative neurostimulation products aimed at addressing mental health issues, utilizing bioelectronic medical technology [5]. - The Nexalin Gen-2 15 milliamp neurostimulation device has received approval in China, Brazil, and Oman, indicating the company's commitment to advancing its technology [5].