Core Insights - Carisma Therapeutics Inc. announced new pre-clinical data on its anti-GPC3 in vivo CAR-M therapy for hepatocellular carcinoma (HCC), developed in collaboration with Moderna, to be presented at the SITC Annual Meeting on November 8, 2024 [1][2][3] Company Overview - Carisma Therapeutics is a clinical-stage biopharmaceutical company focused on developing innovative immunotherapies, particularly utilizing engineered macrophages and monocytes to treat cancer and other serious diseases [5] Research and Development Highlights - The pre-clinical data indicates that the anti-GPC3 CAR-M therapy shows robust anti-tumor activity and represents a novel off-the-shelf approach for treating GPC3+ solid tumors, including HCC [2][3] - The therapy employs lipid nanoparticles to deliver mRNA encoding CARs, reprogramming endogenous myeloid cells in vivo [2] Presentation Details - The poster session at SITC will include the abstract titled "Pre-Clinical Efficacy of a Novel Anti-GPC3 In Vivo CAR-M for Hepatocellular Carcinoma," with publication number 329, scheduled for November 8, 2024 [4]
Carisma Therapeutics to Present New Data on Anti-GPC3 In Vivo CAR-M Therapy for Hepatocellular Carcinoma at SITC 2024