Core Insights - Northstrive Biosciences Inc. has scheduled a pre-Investigational New Drug (pre-IND) meeting with the FDA on April 23, 2025, to discuss the path forward for filing an IND for EL-22 as a combination treatment with GLP-1 for muscle preservation [1][3][7] - EL-22 is a novel engineered probiotic designed to express myostatin on its surface, targeting the myostatin pathway to support muscle health, with preclinical studies showing significant improvements in models of Duchenne muscular dystrophy [2][4] - The company aims to file the IND application in 2025 and initiate clinical trials to evaluate the combination of EL-22 with GLP-1 receptor agonists for obesity treatment [3][4] Company Overview - Northstrive Biosciences Inc. is a subsidiary of PMGC Holdings Inc., focusing on the development of innovative aesthetic medicines, with EL-22 being its lead asset [4][5] - PMGC Holdings Inc. is a diversified holding company managing a portfolio through strategic acquisitions and investments across various industries [5]
Northstrive Biosciences Inc. Schedules Pre-IND Meeting with FDA for EL-22, an Obesity Therapy Targeting Fat Loss and Muscle Preservation in Combination with GLP-1