Core Viewpoint - Bicara Therapeutics Inc. is advancing its lead product candidate, ficerafusp alfa, a bifunctional antibody targeting solid tumors, with three abstracts to be presented at the AACR Annual Meeting 2025 [1] Group 1: Product Candidate Overview - Ficerafusp alfa is a first-in-class bifunctional antibody that combines an EGFR-directed monoclonal antibody with a domain that binds to TGF-β, aimed at treating various solid tumor types [1][5] - The dual-targeting mechanism of ficerafusp alfa is designed to block both cancer cell survival and immunosuppressive signaling within the tumor microenvironment [5] Group 2: Presentation Details - The first presentation will cover the results of a Phase 1/1b dose expansion cohort of ficerafusp alfa monotherapy in patients with metastatic or advanced cutaneous squamous cell carcinoma (cSCC) [2] - The second presentation will discuss the potential of ficerafusp alfa to overcome resistance mechanisms in first-line recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) when combined with Pembrolizumab [3] - The third presentation will highlight preclinical data showing how ficerafusp alfa can reverse acquired resistance to the KRAS-G12C inhibitor sotorasib in KRAS-G12C-mutated lung tumors [4] Group 3: Event Information - The AACR Annual Meeting 2025 will take place from April 25-30, 2025, in Chicago, IL, with specific sessions for the presentations scheduled on April 28 and 29 [6]
Bicara Therapeutics Announces Upcoming Presentations at AACR Annual Meeting 2025