全球首个高精度完整肝脏三维病理图谱发布，研究团队来自上海

Core Viewpoint - The research team from Shanghai has published the world's first high-precision complete 3D liver atlas, providing a revolutionary research tool for addressing chronic liver diseases such as hepatic fibrosis [3][6]. Group 1: Research Significance - The study addresses a significant public health challenge, with over 200 million patients suffering from fatty liver disease in China and more than one million deaths annually due to liver cirrhosis globally [3][4]. - The high-precision 3D liver atlas allows for a comprehensive understanding of liver anatomy and pathology, which was previously limited to 2D imaging techniques [3][4]. Group 2: Technological Innovation - The research utilized the MOST (Microscopic Optical Sectioning Tomography) technology to achieve ultra-high resolution 3D imaging of the liver at 0.35×0.35×2 micrometers, effectively creating a "digital twin" of the liver [4][6]. - This technology captures critical spatial relationships among liver structures, including the liver lobes, bile ducts, and blood vessels, and reveals fine structures like peribiliary microvascular networks that traditional methods could not observe [4][6]. Group 3: Findings and Applications - The study established a pathological atlas of liver fibrosis using a carbon tetrachloride (CCl4) induced mouse model, revealing a correlation between the severity of hepatocyte steatosis and proximity to the central vein [6][7]. - The application of deep learning techniques enabled automatic segmentation and analysis of large-scale 3D pathological data, identifying that the volume proportion of steatotic hepatocytes in fibrotic livers reached 30.76% [6][7]. - The findings provide new insights into the pathogenesis of liver fibrosis and potential targets for targeted therapy, enhancing the efficiency and accuracy of pathological analysis [6][7]. Group 4: Future Implications - The established technological framework is not only applicable for basic research but also offers new approaches for clinical diagnosis and treatment of liver diseases [7]. - The successful application of high-precision liver atlas construction and 3D pathological analysis techniques is expected to be further promoted in the research and clinical pathology of other liver diseases, supporting the development of more effective treatment strategies [7].