Company Performance - Spero Therapeutics reported a quarterly loss of 0.38pershare,whichwasworsethantheZacksConsensusEstimateofalossof0.35, and a significant decline from earnings of 0.96pershareayearago,indicatinganearningssurpriseof−8.5715.04 million for the quarter ended December 2024, surpassing the Zacks Consensus Estimate by 21.32%, but this represents a decline from year-ago revenues of 73.52million[2]−Overthelastfourquarters,SperoTherapeuticshassurpassedconsensusEPSestimatesonlyonceandhastoppedconsensusrevenueestimatestwotimes[2]StockPerformance−SperoTherapeuticsshareshavedeclinedapproximately13.60.33 on 11millioninrevenues,andforthecurrentfiscalyear,itis−0.79 on $60 million in revenues [7] Industry Outlook - The Medical - Biomedical and Genetics industry, to which Spero Therapeutics belongs, is currently ranked in the top 28% of over 250 Zacks industries, suggesting a favorable outlook compared to lower-ranked industries [8] - Empirical research indicates a strong correlation between near-term stock movements and trends in earnings estimate revisions, which can be tracked by investors [5]