Neurocrine Biosciences Presents Real-World Data on Therapeutic Dose Attainment and Dosing Trends of VMAT2 Inhibitors in Patients With Tardive Dyskinesia

Core Insights - Neurocrine Biosciences presented new data indicating that all patients with tardive dyskinesia achieved a therapeutic dose with INGREZZA (valbenazine) from the start of treatment, contrasting with only about half of patients on deutetrabenazine reaching a therapeutic dose within six months [1][5][6] Group 1: Study Findings - The retrospective cohort study included 3,527 patients treated with INGREZZA, 2,166 with deutetrabenazine BID, and 326 with deutetrabenazine XR, assessing them over a six-month period [2][3] - Results showed that 100% of patients on INGREZZA reached a therapeutic dose immediately, while only 47.5% of those on deutetrabenazine BID and 54.3% on XR achieved this within six months [6] - The average time to reach a therapeutic dose for deutetrabenazine patients was three to four weeks, with nearly 10% unable to maintain the therapeutic dose after reaching it [6] Group 2: Treatment Implications - INGREZZA's ability to provide a therapeutic dose from day one without titration may reduce the burden on clinicians and patients associated with sub-therapeutic dosing [2][5] - Fewer patients on INGREZZA experienced dose changes compared to those on deutetrabenazine, with 33.7% of INGREZZA patients needing a dose change after the first month, compared to 48.1% for BID and 54.0% for XR [6] Group 3: About Tardive Dyskinesia - Tardive dyskinesia is a movement disorder characterized by uncontrollable and repetitive movements, often resulting from the use of certain antipsychotic medications [4][7] - It is estimated to affect at least 800,000 adults in the U.S., highlighting the significant need for effective treatments [7] Group 4: About INGREZZA - INGREZZA is a selective VMAT2 inhibitor approved for treating tardive dyskinesia and chorea associated with Huntington's disease, uniquely offering a therapeutic dose from day one [8][9] - The medication is available in 40 mg, 60 mg, and 80 mg capsules, and can be taken alongside most stable mental health regimens [10][19]