Group 1: Booking Holdings - Booking Holdings has turned a 1,000investmentintoapproximately180,000 over the past 20 years, reflecting significant growth in online booking services [2][3] - The company generated over 914millioninsalesin2004,withprofitsof31.5 million, and reported 23.7billioninsalesand5.9 billion in profits last year [2][3] - Despite potential near-term economic challenges, Booking Holdings is viewed as a solid long-term investment in the travel industry [4] Group 2: Apple - Apple, with a market cap of 3.3trillion,hastransformeda1,000 investment into about 151,000overthepast20years[5][8]−Recentrevenuegrowthhasbeenmodestat426.3 billion to total revenue [6][7] - The company has generated more than 98billioninfreecashflowoverthetrailing12months,makingitareliableinvestmentoption[7]Group3:RegeneronPharmaceuticals−RegeneronPharmaceuticalshasincreaseda1,000 investment to approximately 125,000overthepast20years,withsignificantgrowthinsalesandprofits[8][9]−Thecompanygeneratedover14.2 billion in sales for 2024, with net income exceeding 4.4billion,anditsEyleamedicationbroughtin6 billion in revenue last year [9][10] - Regeneron has a strong pipeline of drug candidates and is considered a good buy-and-hold investment, trading at just 14 times its estimated future earnings [10]