The Motley Foolยท2025-04-05 07:23Group 1: Booking Holdings - Booking Holdings has turned a $1,000 investment into approximately $180,000 over the past 20 years, reflecting significant growth in online booking services [2][3] - The company generated over $914 million in sales in 2004, with profits of $31.5 million, and reported $23.7 billion in sales and $5.9 billion in profits last year [2][3] - Despite potential near-term economic challenges, Booking Holdings is viewed as a solid long-term investment in the travel industry [4] Group 2: Apple - Apple, with a market cap of $3.3 trillion, has transformed a $1,000 investment into about $151,000 over the past 20 years [5][8] - Recent revenue growth has been modest at 4%, but the services segment has shown a 14% increase, contributing over $26.3 billion to total revenue [6][7] - The company has generated more than $98 billion in free cash flow over the trailing 12 months, making it a reliable investment option [7] Group 3: Regeneron Pharmaceuticals - Regeneron Pharmaceuticals has increased a $1,000 investment to approximately $125,000 over the past 20 years, with significant growth in sales and profits [8][9] - The company generated over $14.2 billion in sales for 2024, with net income exceeding $4.4 billion, and its Eylea medication brought in $6 billion in revenue last year [9][10] - Regeneron has a strong pipeline of drug candidates and is considered a good buy-and-hold investment, trading at just 14 times its estimated future earnings [10]