鸡也有了“基因字典” 华大智造助力全球首个鸡参考面板成果发布

Core Viewpoint - The research team led by Professor Hu Xiaoxiang and Wang Yuzhe from China Agricultural University has published the first phase results of the Global Chicken Reference Panel (100K GCRP) project, which aims to construct the world's first chicken reference genome resource library, providing foundational support for genetic variation mapping, artificial selection research, and precision breeding [2] Group 1 - The 100K GCRP project is the first of its kind globally, focusing on chicken genetic resources [2] - The project utilized the DNBSEQ-T7 sequencing platform and other systems from Shenzhen company BGI for sample processing and sequencing [2] - The research involved low-depth sequencing of 10,104 commercial chicken samples and high-depth sequencing of 1,847 samples, resulting in two high-quality sub-panels [2] Group 2 - The study demonstrated advantages in genotype filling performance and causal variant localization in both simulated and real traits [2] - The resource library is expected to support the construction of genetic variation maps for chicken breeds and enhance artificial selection and precision breeding efforts [2] - Professor Hu emphasized the significance of understanding chicken genomes for insights into diseases in humans and other animals, aligning with the project's goal of creating a global chicken genome dictionary [2]