新研究揭示人到中年腰会胖背后的细胞机制

Core Insights - The research reveals the cellular mechanisms behind age-related abdominal fat accumulation, identifying adipose progenitor cells (APCs) as key players in this process [1][2] - The study indicates that aging enhances the differentiation potential of APCs, leading to increased fat cell production in middle-aged individuals [1][2] Group 1: Research Findings - Aging causes adipose progenitor cells to transform into a new type of stem cell known as preadipocytes, which continuously produce new fat cells [2] - A signaling pathway involving leukemia inhibitory factor receptor is crucial for the proliferation and differentiation of these preadipocytes [2] - The research challenges traditional views on fat cell formation, suggesting that innovative strategies to eliminate or block the formation of new fat cells could help prevent age-related abdominal fat accumulation [2] Group 2: Experimental Evidence - The study involved transplanting adipose progenitor cells from young and old mice into young mice, demonstrating that old APCs can independently generate new fat cells regardless of the host's age [1] - Gene activity analysis showed that APCs are dormant in young mice but become highly active in middle-aged mice, leading to significant fat cell generation [1] - Single-cell RNA sequencing of human samples confirmed the presence of similar preadipocytes in middle-aged human tissues, indicating a significant increase in their numbers and fat cell production capability [2]