脂肪“小工匠”为啥爱挑中年人“造屋”

Core Insights - The article discusses the increase of abdominal fat with age, highlighting its health risks such as diabetes and heart disease [1][2] - A recent study from the "City of Hope" National Medical Center reveals that aging fat cell progenitors (APCs) become more active, leading to increased fat cell production [1] - The study identifies a specific signaling pathway, leukemia inhibitory factor receptor (LIFR), that drives the transformation of APCs into more powerful "super craftsmen" known as age-specific preadipocytes (CP-As) [2] Group 1 - Aging leads to the transformation of fat cell progenitors (APCs) that become more active and produce more fat cells, contributing to abdominal obesity [1] - The emergence of age-specific preadipocytes (CP-As) during middle age explains the increase in waist circumference even without significant weight gain [2] - The LIFR signaling pathway is crucial for the proliferation of CP-As, which results in the accumulation of abdominal fat [2] Group 2 - The findings provide insights into the mechanisms behind age-related obesity and suggest potential therapeutic approaches to combat this issue [2]