Kytopen and Aldevron Expedite Cell Therapy Manufacturing Through Their Collaborative CRISPR-mediated Cellular Engineering Workflow

Core Insights - Kytopen Corp and Aldevron have entered a joint marketing agreement to enhance workflow solutions for cell therapy manufacturers by combining their technologies [1][6] - The collaboration focuses on promoting the synergies of Aldevron's Nanoplasmid™ vector technology and Kytopen's Flowfect Tx™ GMP cellular engineering platform for CRISPR-mediated engineering of primary T Cells [1][2] Technology Overview - Aldevron's Nanoplasmid vector technology offers high transgene expression and an improved safety profile, while Kytopen's Flowfect technology ensures gentle gene delivery with unlimited scalability [2][6] - The combination of these technologies results in an enhanced CRISPR-mediated T-cell engineering workflow, yielding high outputs and saving time for cell therapy developers [2][6] Upcoming Presentations - Kytopen will present a joint poster at the International Society of Cell & Gene Therapy (ISCT) Annual Meeting from May 7-10, 2025, in New Orleans, showcasing data on increased yield and manufacturing ease compared to viral and electroporation technologies [3][6] - A Global Showcase Oral Presentation will also be held on May 8, 2025, highlighting a fully validated, non-viral GMP platform for engineered cell manufacture at clinical and commercial scales [5][6] Strategic Commitment - The collaboration reflects a shared commitment to advancing cell therapies by streamlining workflows to deliver higher yields of healthier cells [4] - The partnership aims to meet the growing patient demand as the adoption of CRISPR-based therapies accelerates [4]