构建类器官研究全过程伦理治理框架

Core Viewpoint - The Ministry of Science and Technology has released the "Ethical Guidelines for Human Organoid Research," which outlines the ethical principles and requirements for conducting research on human-derived organoids, emphasizing the need for strict operational norms and ethical boundaries in sensitive research areas [1][2]. Group 1: Ethical Guidelines Overview - The guidelines were developed by the National Science and Technology Ethics Committee's Life Sciences Ethics Subcommittee, focusing on ethically sensitive research types such as brain organoids and human stem cell embryo models [1][2]. - The guidelines aim to establish a comprehensive ethical governance framework that covers the entire research process, ensuring scientific goals are clear and ethical norms guide innovation without hindering research [2][3]. Group 2: Specific Requirements - The guidelines require that organoid research must have clear scientific objectives, sufficient scientific basis, and verifiable scientific value, while ensuring ethical compliance throughout all research phases [2][3]. - For brain organoid research, there is a particular emphasis on monitoring the development of complex neural networks and spontaneous electrical activity, with a focus on potential consciousness attributes [2][3]. Group 3: Restrictions and Monitoring - The guidelines impose restrictions on the cultivation time of stem cell embryo models, enhance process monitoring, and clearly define prohibited actions to prevent ethical breaches [3]. - It is explicitly prohibited to implant stem cell embryo models into human or non-human animal uteri, maintaining strict adherence to ethical boundaries [3].