Study shows patients treated with Smith+Nephew's CARTIHEAL™ AGILI-C™ Cartilage Repair Implant have an 87% lower relative risk of Total Knee Arthroplasty or Osteotomy at 4 years¹*

Core Insights - Smith+Nephew's CARTIHEAL AGILI-C Cartilage Repair Implant shows promising results in treating knee cartilage defects, outperforming the current surgical standard of care in a recent multicenter randomized controlled trial [1][3][4] Group 1: Product Performance - The CARTIHEAL Implant has received FDA approval and breakthrough designation, indicating its potential to transform the cartilage repair landscape [3][4] - Patients treated with the CARTIHEAL AGILI-C Implant reported significantly better knee pain relief and quality of life improvements over a 4-year period [6] - The implant demonstrated an 87% reduction in the risk of subsequent total knee arthroplasty (TKA) and osteotomy compared to the surgical standard of care, which is a critical consideration for patients with mild to moderate osteoarthritis [4][6] Group 2: Clinical Outcomes - The implant effectively treated a diverse group of patients across various demographics, including age and lesion size, while delivering clinically meaningful results [6] - Professor Elizaveta Kon emphasized the importance of inclusivity in study design, noting that the CARTIHEAL Implant has shown superior performance across genders and lesion locations [4] - The technology is particularly beneficial for patients seeking procedures that allow them to maintain their daily activities, such as playing with children and grandchildren [4] Group 3: Industry Engagement - The CARTIHEAL Implant will be featured at the Arthroscopy Association of North America Annual Meeting (AANA 2025), highlighting its significance in the medical community [1][5] - A lunch symposium will focus on the use of the CARTIHEAL Implant for treating various cartilage pathologies, further promoting its clinical applications [4]