Core Insights - PacBio reported an adjusted loss per share of 15 cents for Q1 2025, an improvement from a loss of 26 cents in the same quarter last year, exceeding the Zacks Consensus Estimate by 21.1% [1] - Total revenues for the first quarter were 37.2million,down4.316.3 million, an 8% decline year over year due to government funding challenges [3] - Asia-Pacific revenues totaled 11.6million,reflectinga99.3 million, an 11% increase, driven by strong Revio placements in the hospital and clinic segment [5] Segment Analysis - Total product revenues were 31.1million,down11.111 million [6] - Consumables revenues increased by 25.6% to 20.1million,withannualizedReviopull−throughpersystemat236,000 [7] - Service and other revenues rose 57.9% to 6million,attributedtoincreasedservicecontractrevenuesrelatedtoRevio[7]MarginandExpenseTrends−Adjustedgrossprofitincreased18.815 million, with adjusted gross margin expanding by 700 basis points to 40% [8] - Sales, general, and administrative expenses decreased by 8.2% to 40.2million,whileresearchanddevelopmentexpensesfell33.229.1 million [8] - Total adjusted operating loss was 54.2million,animprovementfrom74.6 million in the prior year [9] Financial Position - At the end of Q1 2025, PacBio had cash and investments totaling 343.1million,downfrom389.9 million at the end of 2024 [10] Guidance and Outlook - For Q2 2025, PacBio expects revenues to be flat compared to Q1 2025, with a Zacks Consensus Estimate of 36.9million[11]−Thecompanyrevisedits2025revenueoutlooktobetween150 million and 170million,downfromthepreviousguidanceof155 million to 170million[12]StrategicInitiatives−PacBioinitiatedacompany−widerestructuringplanaimedatreducingoperatingexpensesbyapproximately45 million to $50 million by the end of 2025 [14] - The company entered a licensing agreement to enhance methylation detection capabilities within its HiFi sequencing platform, which is expected to expand applications in cancer research and rare disease diagnostics [15] - Performance was impacted by macroeconomic challenges, including reduced academic funding and U.S.-China tariffs, leading to a decline in Revio system shipments [16]